It was suggested that combining multi-biological data to study the pathogenesis of

schizophrenia and develop diagnostics for schizophrenic, an integrated framework could

be useful. [86]

Eugene Lin, Chieh-Hsin Lin, Hsien-Yuan Lane 2021 propose that employing a tagging
aggregate machine learning technique with selecting features to develop software tools
for predicting the functional status of psychosis using nanoscale drug delivery could be a
viable option.

Yi Ji Bae, Midan Shim, Won Hee Lee,2021. He demonstrated that identifying

psychopathology required the use of consistent conceptual sets of words. Their findings
suggest that using social media texts to study the linguistic aspects of psychosis and
detect mental illness or other at-risk persons could be aided by machine learning
technologies.

Frick Janek, Thilo Rieg, Ricardo Buettner 2021 prove that occurrence potentials can be
utilised to accurately detect psychopathology. They reach an overall precision of 96.4
using a machine learning technique, which outperforms all comparable results.

Foresight and Planning:

There is a tremendous potential to see if machine learning can detect SZ with similar
accuracy using other medical information. There must be presently just a few public
statistics available for investigators to utilise in order to use cutting-edge AI and machine
learning techniques. A collaborative effort might hasten research into using big data to
improve medical practitioners' experiences. We warn against using machine learning in
place of other exploration or analysis approaches. Instead, this adds value to
Schizophrenia research by supplementing it. More interaction among research centers
and health agencies may be required to meet the need for data-driven research using ML
techniques.

6_RESEARCH GAPS IDENTIFIED IN

RECENT WORKS:
Table_1: Research Gaps Identified:

S Article
Research Gaps
Achievements
Identified
No. Details
 (a)The
forecasts of the
PAI

(Personalized
Advantage

Index) model
are skewed. It

could be as a
result of

missing
Her work could predictor
provide variables

practitioners or the use of a

with a method linear model
to
rather than a
compare the non-linear
Monika
finest of
numerous model.
1. Mellem et al.
possible (b)Another
(2021)[75 ] remedies to an drawback is
that
individual
condition if it testing is
has limited to a

been properly particular data

validated. set. A more

solid strategy
would be to

put the BRL

(Bayesian Rule

List) model
through its

paces with
different data

sets.
 By highlighting
breakthroughs

in current
The findings
application
provided in
areas in
this
practice, this
analysis
paper
illustrate need
to push
summarizes
the literature
the limits of
on
Artificial
Joel Weijia Lai machine
intelligence
learning and
And machine
2. et al. (2021) deep
learning in the
[81] learning data
healthcare,
with
application
providing the
opportunity of
to SZ. This,
however,
employing cannot
computers to
improve
invalidate
ongoing non-
SZ assessment
capabilities.
pharmacologic
al therapeutic

research.
 Their article
presents a
complete

description of
SZ assessment

approaches
utilising
Neuro-

imaging modes
and

computational
intelligence.
Delaram
They
3. Sadegh et al.
have compiled
a list of
(2021)[82]
computerized
technologies
that

have been
developed to
identify

Schizophrenia
promptly and

reliably using
neuro-imaging

modalities.
 Given the
detrimental
impact

According to a that a
rising number misdiagnosis
of or incorrect

methods meant prediction can

to improve set have on a
of
person's life,
possibilities deep learning-
Jose A. Cortes- and descriptive
powered
4. Briones et al. analysis and systems might
inferential,
(2021)[83] learning necessitate
ongoing error
might become
a valuable evaluation
thoroughly and
technique for
assessing the comprehensive
ly, and as such,
mechanisms
behind SZ. can protect and
enhance a

person's well-
being.
 The
researchers
worked on
With a positive
understanding predictive
human DNA
value (PPV) of
methylation 80 % , the
data, and
algorithm
identifying correctly
individuals diagnosed
with the
85 percent of
highest risk SZ SZ diagnoses,
using a
machine- much
exceeding a
learning model
method.
Chathura J.
trained on
According to a PRS.
5. Gunasekara et
rising number
of Their findings
al. (2021) [84]
are based on
methods meant
to improve set only 10 % of
of known
CoRSIVs
possibilities
and descriptive that are
informative on
analysis and the
inferential,
learning HM450 array,
as a result of
might become our
a valuable
reliance on a
technique for certain
assessing the platform.

mechanisms
behind SZ.
 (a)Broadly
speaking, the

findings show
The DT that the links
model's
adaptation
between
symptoms and
efficiency was
calculated
pragmatic
manifestations
utilizing 10 fold
cross, a
are weak.
method
(b)Moreover,
of testing
the only
computer
simulations
phenomena
being more
it divides the
original sample
reliably
associated with
into a test
6.
dataset as well
as a clinical
symptoms
(BSAs)
testing sets.
The
researchers are not among
those chosen
worked on
machine by the decision
learning tree

approach to classifier used

perform a in the main

multidimensio analysis to
nal analysis of differentiate

communicatio between
n skills. schizophrenics
and

healthy
volunteers.
 The
researchers
built an
(a)The
researchers
integrative couldnt
learning
algorithm
declare that
immune-
consisting of a
Peng-Fei Ke et
combination
7. on inflammatory
al. (2021)[86] indicators are
multibiological
information, altered from
the start of SZ
which would be
a potential because this
study used a
avenue for
identifying

cross-sectional
design.

(b)Comparing
biomarkers for the two
detection,
participant
prediction, and groups, there
therapy of
was a
Schizophrenia. significant
difference

in schooling
years.
 (a)These
findings are
new and

have not yet

been put to the

test in terms of
external
The validity.
researchers
worked on
(b)The impact
of medication
detection of SZ on
via ML
the model has
Frick Janek et algorithm yet to be
8. and,presented
al. (2021) [87] a novel
determined.
strategy to
prophylaxis as (c)The data set
a non used is also not

invasive particularly
approach. large, which
can

cause
considerable

differences in
the

algorithm's
performance.
9. Eugene Lin et The It could be a
researchers useful strategy
al. (2021) [88] worked on a for

sweeping constructing
ensembles predictive
machine models

learning for functional

approach with outcomes in
such a
schizophrenia,
feature according to
selection the
algorithm has
findings.
been used to Finally,
evaluate the researchers

functional anticipate that

consequences the results
of
would be
schizophrenia. applied to
predict
This research
offers a diagnosis but
the treatment
substantiation
for a ML outcome still
has not been
predictive used
approach for
yet.
schizophrenia
treatment

recovery. The
findings show
that

the bagged
composite
learning

algorithm
could be a
 therapeutically
useful tool for

predicting
schizophrenia
clinical

outcome.

The findings
suggest that

utilising
machine
learning

techniques,
scientists
might be
Yi Ji Bae et al.
able to better
10. grasp the
(2021) [89]
linguistic forms
of

schizophrenia
and use media

platforms to
identify

schizophrenics.