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Review Annu Rev Neurosci. 2015 Jul 8:38:433-47. doi: 10.1146/annurev-neuro-071013-014030.

Epub 2015 May 4.

The brain's default mode network

Marcus E Raichle 1
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PMID: 25938726 DOI: 10.1146/annurev-neuro-071013-014030 Collections

Abstract
The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the
medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human,
nonhuman primate, cat, and rodent brains. Its discovery was an unexpected consequence of brain-
imaging studies first performed with positron emission tomography in which various novel, attention-
demanding, and non-self-referential tasks were compared with quiet repose either with eyes closed or
with simple visual fixation. The default mode network consistently decreases its activity when
compared with activity during these relaxed nontask states. The discovery of the default mode Title & authors
network reignited a longstanding interest in the significance of the brain's ongoing or intrinsic
activity. Presently, studies of the brain's intrinsic activity, popularly referred to as resting-state studies, Abstract
have come to play a major role in studies of the human brain in health and disease. The brain's
default mode network plays a central role in this work. Similar articles

Keywords: activation; attention; baseline; functional connectivity; intrinsic activity; memory; resting
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state; self.

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Review

MeSH terms
Animals
Brain / physiology*
Humans
Neural Pathways / physiology*
Rest / physiology*

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