oe tere we Speoction bth 02 2 etal > X12 cdicarlerry lie actos 8d xerot Lith LTA ong and give oliferte confrourrcls - —¢=CoOPb(OAe)3) -(eo0- : T 7 3p) -(€00- Plone), = Gr e00H + PbO) Rea? rte a ° —Cc- COOH I ia i 2 ' 4 da beg Ties aw oO Aker # LTA de wel to manufacture cycle We siiplisation of rateratedl aleope : pth of retioated aleapal having a dugcliagir Lx ne fella portion pttle ELTA a otra Aerts an eyolinteon of He alcotol (cycle er), y—-\ LTA we jie 2 LD en ve -ve chowge peclaocediiees colatol) Te Teloneh, y J —\ i S—~ eal P rege Le a 1G ao 5 phan) - § nf ele ou —acoul — Po(oae); —\ = He Cus 2—— he ‘CH Ip ou My Pelone)s ‘ -ut elhe ‘i : oY _ ; TUCO aphs) addin af bydagin, poi of 3. ydeegunely ss - add H ad soevale the tal. HE InyebricleTutt attevelioyr ¢ seme [Pesberrsy , 24 P1(Nos), +: PLOz + GNb, +0, 4NUG i" + HIND, yt oy 6 NaNb; — Coches = | 4H BD xcormended rot 1 ure Boyne a *) aboard in ‘ilabyyiy 09 0 doar > Pd= Basu (Roremmuna Reactianr) od Petmuing 49 Cermoneiine rato! 10 comvert Lhyrng 10 alleen, > Po=Cacds (Linollaxs catabyt) tusening deactivated Ap Lend fecile is) bene sida pincvsdie soeg) bere! A? |, — tuddovrty quenched Pipose weliirn LO py didrduing 40 Morg Nien) . noon. A soy of Ne, fend 408 WX. Ancnos, PP rose)” roe loee) coder . pole 0 [ere prob amour, = 3 4 articl ppt tr fyrmeol. Pact it path pate erred fom ik inily. a povelor A geeysit Lley Higby poseuy Prodi tn Jatrato! -Femevucel than Poo tar geduce cxtes 40 asbeotralr, owvidles ~p amives , 2% fn oll octal boned cetobiyrts, tree to ynignotion Lake /} ben poahioflr bovd te rifile tend ~ deopach (hoffen be Alper furretiovel IPL.He ‘Si == a ; # fh we peas of COLE Borel ae a of atacliitiy a diecull Ase vfe fe ZUG to tee nurfoce aber belecdgeregcis +R oo ental (otestOd dm Vemagenea ed cetlalygta dev cali wart fo! - fi e )phrocliom (Z) on popndtaninn [DBE ype _ bea De ph caplit vn dliivad by te eee rd pidh once ipo proper’ pls 2420 + Cilidy? AF > [Carpe excesal ae Yt + fGovs)eP], Rae ; Leo slbave wnaaion bait [duck feilbes) fod LG ~ coo u / etal Peduction. ‘ . . “—_ ie Ne k, 2b Ere Ce B FH EtOH 4 sodile itr in tre abtnct of publons (od iy of proto clavrnsiiigia penned Hore, oe the presuce of préton. Na/ether we Ses > te “f Cte 9 G8-g ge vive prone ti aia Gi, by ite i on\ Difeioone Prslons’ a -co meg f = | eae op aie Liahitts Gils coe PEE. Gels, gies 8 @ | dpubhosee i” praoeree, , "Gls 2B -cels ts ats -d-ceHe " o 2 ; o 4 G -e- sol ate Cee eee ea on cas | “ iy (Rr 20d) pownelt- Blanc Redluctore (fetiely 2! ee mmabwa reduction of oflory pith radian amd Pop! nar nla: BH p_cy,oH + 2-0 R-c ss|/44 3 Commoner. Reduction ae eta es aafg — Hel. Medan | | bo Ake 2ell p -4G~p) | ° ee et f 2a [UU ! Hes ! | g-e xp! Zeolite poe 2G Np | are Pree (3 £ co RO EXp! — 420 R~] 2 Ath Zn . om © re i He e Roe-R' Ea fatal —— > Roe! ! Hu Blt a: Coe Ms 2r/HO exer"oo “ae i op wl nel wi oy he 2% pO prope ae Melee Crit perch aluaing 19a oe Mg Apron fn 1,4 -cyclatercacleive?- io) sag if bol Aogyyts, Noe KbUT br bighty cio atltin ond! it fn cnthlld Bf POE wetene y i, | ee bogpi: ) ik ztobile toe fe ee anton Aaclicle lndetrasecde Y & dompating “prs ate pruced (ite rilbory qioupie) it leriatitocs W* —ve age on te fadich oe ‘ache it ro oenad that, sae 00 OY bl von ngeresd conjuagedlid Wires Ss p Nib Nia Hho if 2 CSE hie medion BF ~B! > o oh oer? + Nir, ——_ PY. oe fig bace irdtagive, 2 —#H Hyctagene Drhmesee poten ) oe nEubay he Hs A fe ; \ _ < SEN INAH em =Np "7 << — ale BN Be BSE nena ea Yo J Epa, PettTepito Aloe Slows & one ome vs a CQ Co RAN ow rt oe old» aoe 2 oMe I" Set ee _| Nant oe 2 M hep wctelrde} te lle: Biel solution ot_eouvsniomef elle ce —e' + Nala Slt i vai, PN po By SEE Berek ~ e-c8e pt Ry eal evel | ae 2 na o a hae nis oc e Raho METALL TC REACT | Gaupnasd Reactor. Cparomgagveniun) 2 Begoneobitiriitan 34 Biganafeallacliuan (5 numtd Scactigzs)Ob fend am place © orf a dah ige T met, pundl carbon agra: | = Dif 0 tlle: compound! bx 3 2r -CH9fpi0d,/ — panel [orp orgawarodtalis comprowend: fy: 9 i, Irie Couodlee: (dertooing Ad) Kno, bi, My, AL, 20, ed 1G | ASeiprase Reagent: ROK + Mg Whiten 5 Bg | nfw Corniccl out im obrobecthy diy conlitiyn | Aa tn sequel (162 boos) | | bie ill Ke ig ell | es aould Le kt 5 times mote fran R-x- | cloauld vol fe preasrted Ub vere Ivan 2. doagp Manivoum effecimey io for the B pout covlairuig bart ng, 1% Conlon chen. ot che -) CHg -x hog ofriowe | os jee, C dim , cant powvattin. Ate%vazes | type of Uabidle ions ~ > pn>2 1) Wn yruyorad a Z vs Onftnnve C-x p— Meyl palide C= | iyinic bolas se Cu» fod 1 thong Prerigl dralide ne gota Oe eB all eae, cng td on di. 7 @ di. can le cle gn parce Jf trong lapte Pox, THF fo ud 00 obverd eH)\fo4 en: x ap Mn Ler feochrire Tg Bn vot wd at ofl. 22 in vied tn widuttiiy ar tr Borromical I in wh un Rad D.gal 12" PF pe pt pe re Mg + MgX2 —> 2Mbx MgX + B-x ——> B +MgX2 R+mgx —_, R- Myx ci ace Mg R-ezcy FM, p coe _mgae + 2 Cie mi echiger rt Aorucoleon : Ache pake of darmottinn of foe Gxignocdl conn be erificerily wiprovel by A gelation (ublsa voriéalion . ‘igi fepueriy round pradacts Coniteitinn feoding to Vij ined ee (OWN obi, oe fotted Ht Lor te ‘ip of toe babble bcteanes A Prtrnbe nea te pwrertorda te HOG Soon tavepaund ia vit pate nencitive ep 7 ae \ Gurefeclior pte o hy é) 0 ohn 2o[1 ou ie co-rdivalt Fvboge Mae aad = (0,4), (aH),tinea), Oxtprard a A Zoe9) Bue te fe —ve chatge om €¢plaxined) Ad, ' uses of logfile Leos 40 nucleophilic Seactigna ( CMsMgE + H-OH —> CHa + mgloW)T | Clgmgr + ROH —> CHa + mg (02) +N > cH, + mg (wet FEN —> cu + My (ENE # 2erutinelt] avalysia of active dugdbagen By meaoy wecanuicingy fhe amount % rtthane fawreof Kem a kugen pt e Obrnfiocerd ‘Covilaniing active Irydhegern , toe” no. af aedioe =H patron a a moleonte bio me bone im Btignana Atagent 2 polar and | sy: wfpranadto tLe | generates nrucltoppitee cos bor, an fg te ! : a vroemal * boviel pharcrle ' _ 6 -Mgx Fok - os Neb + B-Mg-BAx ——> awn eet” fo | | ve : i: NUL=- 27] Repti pith allibrgels < oR | G2 seach vith abdlihgcla owed gives gn add | vic om dyceligrn givens 2° alata Product ¥ S- A Sy ei chy ~ 6 £6 + YHs—Mg-I > ae a a7 tN 4, See oo Hyot c . Hae ere | i talpi 4 rly Ftovaldelrgale gives 1° pbeohal, U-G=0 4+ CHy-mg-T—s Ha Bag Hog Mao “a U~ cus “7 Nousy gol ['24 A thete are yor dritaven bre fw geackonr Lr an Alifyde avd aah gh! a kdave avd 4 1° abeobal Ther cr glue 10 Te hyclitale” hiff aid alas dine foe excey of parivce of ation abddhyde diaing He sectn: | en | (IR + XM» 2. Vbtgx/g We i Gy) A Bere 2 wc Sey POR | Plenson Reowtion sxithr hectares: Gka R0nct pith ketore and Hey give 3° aleotels. Use CH; og x Nose b ct Mg EO pe O_o VE Hs? SCH ay a Ge ens crs B° aheotrel B . a OH cavertso, LCR Os set ap e080 of cliff geaips G Po ——~z . vie dat sig papage: (YEO _teetid Ce!“SOETT 2: : REPL ERY, dthere ane ger Anatiwon store tov sanction Aho au delddiyst quel 2k giver a kloan and A _ 1? skeotel, Tw 4 “ay fo 18 hyelicole” Weal avd aZia di’ fo the es) of pacenee 3 gover addeliyd teria tye xareton er ee Fe ZO va ee Hu pe NO go? Grgy Wbmr PHO MO! ple ~ au aleatel h = Reaction pith ketones: Gla xtact pith belove and they yore 3° altobly Mie eM omg Yeo 4 Oye My 4 7 ere 7 cH Son em 4 8 wer cre x cy “ery 20 teotel BA Caras > Or is lly coe Ce i MMs prety ely ayn cane gape 4 . Rr a a we ae g gegy® CYS tesa Ce! ai t)'24 . : Reaction pith esters! ae peact itl extn ue aa ethgl formal anol ; l ortrofptwott jo gure te corrtrforolirg carbon a (clddbugela). Wee carbonyl corpestinds wars ‘tend pritle tre encen of ASR 10 Yor OL fordiny : 4 Hae ony x 0 a ° 07 Saar a ccmemge + BON peg Wye” DO GHe nye — etiyl forornl Z Lens ts ow eae 26, Hs Ol (Cigar + H-e= oeyg > eter (G14), za Note ethyl otthofotmats » Cliew rbemisthy — firtiedy cantanung 110, py 4 St soi odyhection pitts Neil Chtnudlea: pero! chrboriden (P- -t) Atooh Liha OP and YIP cotreyioncling Uelovin stich war porto, Hot sil the prowncl Y Cneen Y Gea avd fawn 2° wavbol KS Ct J We Lyf nae He. Lo Wye. Orgx A elaet We a NO, e Hs We Hs, ~*~ | = pation pth biol prbaydicde : pbio-d-w | Gp peak phn cio! onus ad grey volt Aor (bore) pbuh wag fordber reoed On Oh ly exc”) evel teed Pre PUM Y 2° aleotel (yertelly apooeatica) | 1? (fogx : | Fm \ Oo | R-mgx + BF ay x png Lb B p> pide e-e PB , z | o 3 Miche GLP GE | 5 peaction psith froioles. 1! 10s GRA Atoct vith amtely to gore add “prooluck hich on falter dnydiolgris gurea toe corctspandingYF. © [be 3 pomgx + Pro —> [Se | de [Ni-Mgx | Ro Stig 5 fachin pis fponials ety alte say caneh pits anymore ofpartibs #-ave heats MEA joe clang of YG phew gen scoot vite wmgwonttatcal, oforidl — xe GUA om toe Leak 1 cantons get : A > Cea Ha-Ha 18% crepe ow cis 4 NS oF ons Ging Bx 4 HC # ne OM > Ge che Flt -Cy ES Ge Hyd, H9* “ > Reoction vith casbar dhcp: Gea com reach pith Ce gallered by Iydhdliyit the carboruplic actol (at foo tof.) Peet Yt feed ld 1 Yt om Ae erhameed: oo piegr Pe os pel Stage ABs revo + mda oO = 7 pith tule - —- 6/2/20 GPs tect wth yibula (REN) yulolong enor wena Y Hen Caypohogern agamide ) pat) ’ powder He q arKepordivg ablebrydle (paMgx + R'CFN ——»: ppi-c=nmyy 825 peleluct (itromediate cartivesing aids 0 yl mall) 7 a 7 , 0" p- E-p'- ES 4D — pReaction pill exygen pruygon sencts pit Ses ot boss temp T govern am volduct tie on actilypcmbon goa | (Cs), e-Mgx + 03 ——> (CHs)s c-0-0 ty | oserrorel . | ‘ . hedtaptiapisle (vit Even | sacl cbeal me quoted in vite tase a 90h | consti 4, hixdheprngride tollle). in prouvee FHF | Penp tooge 5 elon he (asta) a] x Ges xiack itn jubphur {2 ge toes SR yt B-Myx +s —> py BS pecy + My/on)> x tiiol 7 Kye diribfrbride : . 4 Jann 30n vddot bier on quater Mydkobysie gis dite cht _— Y on Oy myx + 202% —> S=6+S-Mgx 3 vil ape 4, ona: to fosmr ulpbinie atid Po (RRGx +S, 3 a Hot peg on | Aynibons 9 jtilime: = is _ Che CHoF iss Gls OM MARA + Gg CHO my gage * . 4 Hs oy COME CH= CI Oo 1Mg Zz a] 49% / _, Abhllene =o ; a y wmatewal a, any endecsteatn (errno . (dagredewh, a. myprtoona of oppteial elbera ; (werynmctical eters) a —= Cig CHa) Mg Ba 4 Clp-O- Ch 5 CH hy - O-Cty 48 : Got otyf) WW . : Cs MgBK 4 NCWCN —> Chace 4 14g (crv) Ba 4. Aynttronis x Frama Avwnty : Giaygi + Ne —> ctyniy + ny LYE 5. Ayntoia of tydecatans . LMgXx + 420 ——> RH > 4 plily an und ag 2 proowset . a 4h, ~ 4 ale Of bn 7 * .| Taf ae DS Traninatallation : 2 fore ove 7 andr relat # Kannlc vo tHe nln wf He bord | -dn sigamonnetialic + sealer P Hams - con snorerioaton | Ke sige Seaction phere Conversion of @ Bans cra wts co pov tok place (23 Cae sans dencetilrn ome ak vm of 9 fotem 10 Haw (om taker plate i Hi & po ty tegelhide Chimincion: ; et in which otal abkgl yfcetel yi areded wee metal tuyplricle - aviel o4fer pte s YY wees NSB. [ee con Ss a > pdt, Bs pct ya rary MfpqlZLe 5 uiteally A call aolels to an seve 10 give Vi -tarefes T. Embt OG g lade 7 Le soplin ebiittr Confilin and! jules vlatian eacomnpcter Ly Pr pied lim” ste gomban the prorat Oe reductive elommotion of a prolan ano Cb gory pale) Qenolly on Artatonird pil Colle rently oe pegenssotion of PAL 23] 3 ob. Pages: 2 it 7 an swelustiwally snp preety go foe Lasg, obi ranlatture oY actlabalitaydle fore elrylone (erecv, ) Phu pases unten Vl catalyst wel vate 2 wed as a ee ee a) aie ae wire sn fevodedl, tebe with Cull, 40 Atgenstate Wh, ? R g on ou 7 Pi» f\--- Le + Pk a prem hal aM Pa 8 t 2 A-a - L ° Wh, 2 wn 4 wa if ow a PR cus = UN | ee —— ’ Cia elavnwenlions 9 beck Coupling Wack peodtion | Te coufrlong yu deere pth a Lalicle (2-x) om feet of PA catalyrt pre & mee alhent. Hur be Fran 2 Meek couplivg vw Alo) R Rew + NY hin Sv _ + 4x