SCHEME & SYLLABUS FOR M.Sc. Chemistry (2018 -2020) Under (Choice Based Credit System) MULLANA-AMBALA\ Chemistry Department Maharishi Markandeshwar (Deemed to be University), Mullana Ambala, Haryana INDIA-133207M.Sc.Chemistry__ Scheme and Syllabi_ (2018-2020) THIRD SEMESTER SNo.] Paper ‘Paper His/Week | Credit | Marks Code ‘Lecture [Practical (Ex+Int) T__[MCE30r ‘Advanced Inorganic Chemistry a = + [1o0r60=40) 2 | MCH-302 | Pericyclic Reactions and PhotoChemistry | 4 = + [100(60=40) 3 | MCH 303 “Advanced Physical Chemistry a + ]100(60=40) 4 _[MCH-304 | Reagents and Heterocyclic Chemistry [_ 4 = +_ (10060740) 3__| MCH-305 |“ Inorganic Chemistry Practical-IIl = 6 3__|10040=50) 6 | MCH-306 | Organic Chemistry Practical-IIT = 6 3 [10040=80) 7_[MCH307 |" Physical Chemistry Practical IIT : 6 3__[10040=50) 3_[MCH308 Summer Training = = 6 | 10060740) Total 16 1s 3 ‘S00 ‘Summer Training presentations/evaluations will be on Saturdaysyllabus of MSc Chemistry-3"' Semester ‘MSc. (3" Semester) Chemistry MCH-301 (Advanced Inorganic Chemistry) Lo oT P Continuous evaluation40 4 o oo End semester exam 60 ‘Total marks 100 Credits 40 Course Objectives: To get an overview about chemistry of non-transition elements. To give students a comprehensive understanding of the stereochemistry and bonding in main group compound. To have an idea about the metal-ligand equilibria in solution.To develop interest in the field of organometallic chemistry. UNITI ‘Chemistry of Non-Transition Elements Polymorphism of carbon. Phosphorous and Sulphur, synthesis, properties and structures of boranes. carbaboranes, borazines, silicates, carbides, silicones, phosphazenes, Sulphur-nitrogen compounds, onyacids of nitrogen, phosphorous, sulphur and halogens, intethalogens, pscudohalides and noble gas ‘compounds. uNIro Stereochemistry and Bon: Main Group Compounds VSEPR, Walsh diagram (iri and penta-atomic molecules), dx-px bonds, Bent mule and energetics of ‘hybridization, some simple reactions of covalently bonded molecules. ‘Metal-Ligand Equilibria in Solution Stepwise and overall formation constants and their interaction, trends in stepwise constants, factors affecting the stability of metal complexes with reference to the nature of metal ion and ligand, Chelate effect and its thermodynamic origin, determination of binary formationconstants by P*metry and spectrophotometry UNIT ‘Organometallic Chemistry-I Oxidative Addition Reactions : Introduction, coordinatively-unsaturation, the acid base behaviour of ‘metal atoms in complexes, acceptor properties or Lewis-acidity of complexes, mechanism of addition of specific molecules-hydrogen addition, HX addition, organic halides and addition of some other molecules. Reductive Elimination Reactions : Intoduction, Migration or Insertion Reaction, Insertion of CO. Promotion of alkyl migration, insertion of CO into M-H bonds, other aspects of CO insertion reactions, transfer to other molecules-CO:, $02, NO, isocyanide, insertion of alkenes and C-C nsaturtted compounds, Cleavage of C-H bonds, Alkane Activation- Cyclometallation Reaction, Oxidative addition of weak acids, reactions of free hydrocarbons. UNITIV ‘Organometallic Chemistry-II ‘Transition metal —Carbon single bond-An Introduction and types of compounds, acyls, formyls, synthetic methods for M-C bonds, decomposition reaction, a, B and y-hydride transfer reactions, intramolecular reductive elimination, other reactions of M-C bonds,Transition metal carbon multiple bonds : alkylidene complexes- Low-valent alkylidene complexes or Fischer carbene, High-valent alkylidene complexes or Schrock carbene, Alkylidyne complexes-low- valent alkylidyne or carbynes, bridging alkylidenes and alkylidynes complexes. Course Outcome: The students will be able to discuss chemistry of non-transition elements like N, S, P and halogen etc. They will be able to discuss VSEPR theory and its applications, bent rule ete In ‘organometallic chemistry they will be able to explain the oxidative addition and reductive elimination reactions, organometallic compounds involving transition metal carbon single bond and muhtiple bond. Instructions for paper setter Time of Exanination: 3 Hours. The Question paper is divided in to two sections A and B, both compulsory. Section A comprises of 12 questions (3 fromeach unit) of one mark each. Section B comprises of 4 questions (1 from ezch unit with two alternatives) of 12 markseach. Text/Reference Books: 1. Advanced Inorganic Chemistry, Third Edition, F. A. Cotton and G. Wilkinson, Wiley Eastem Limited, 1972. 2. Advanced Inorganic Chemistry, Fifth Edition, F. A. Cotton and G. Wilkinson, John Wiley and Sons, New York. 3. Inorganic Chemistry, Principles of Structures and Reactivity, J. E. Huheey, E.A.Keiter, RL. Keiter, HarperCollinsCollege Publishers, 1993, New York 4. Concise Inorganic chemistry, Fifth edition, J. D. Lee, Blackwell Science Limited, 1996, Oxford, UK‘MSc. (3rd Semester) Chemistry MCH-302 (Pericyclic Reactions and PhotoChemistry) Lo oT P Continuous evaluation40 4 o oo Endsemester exam 60 ‘Total marks 100 Credits 40 Course Objectives: To know the different types of concerted reactions in organic chemistry and orbital correlation diagram. Students will be provided the detail of cycloaddition reaction, electrocyclic reaction and sigmatropic rearrangement reactions. They will be familiarise with the important photochemical reactions in Organic Chemistry. They will be given insight into the application part of photochemistry Unit] Pericyclic Reactions-T Molecular orbital symmetry, frontier orbitals of ethylene, 1, 3-butadiene, 1, 3, S-hexatriene and allyl system. Classification of peticyclic reactions, Woodward-Hoffimann correlation diagram. FMO and PMO approach, Electrocyclic reaction - conrotatory and disrotatory motions. 4n, 4n+2, allyl systems, ting opening of cyclopropyl halides, cycloadditions-antarafacial and suprafacial additions, 4n and 4n+2 systems, 2+2 additions of ketenes, 1,3-dipolar cycloadditions and cheleotropic reactions. UNID-U Pericyclic Reactions-IT Sigmatropic rearrangements — suprafacial and antarafacial shifts of H, sigmatropic shift of H. sigmatropic shifts involving carbon moieties, retention and inversion of configuration, [3,3] and [5.5] sigmatropic rearrangements, detailed treatment of Sommelet-Houser, Claisen and Cope yearangements, introduction to ene reactions. Simple problems on pericyclic reactions. Group transfers and eliminations UNIT Photochemistry Excitation and excited states, Franck-Condon Principle, Jablonski diagram, energy transfer photosensitization, quenching, quantum efficiency and quantum yield, Photochemistry of Alkenes: Intramolecular reactions of the olefinic bond. geometrical isomerism, cyclization reaction of conjugated olefins, rearrangements of 1,4- & 1,5- dienes. Enone and dienone rearrangements. UNITAV Photochemistry of Carbonyl Compounds: Norish type I and type II changes. Intamolecular reactions of carbonyl compounds- saturated, cyclic and acydlic, a, B-unsaturated and B, y-ansaturated compounds Photochemistry of cyclic ketones: Patemo-Buchi reaction and Photoredaction Miscellaneous Photochemical reactions: Photochemistry of Aromatic compounds (substitution, isomerisation, cyclisation and cycloaddition reactions). Photo-fiies reactions of anilides, Photochemistry of Azides and Diazo compounds, Barton reaction Applied Photochemistry. Elementary idea of Photochemistry of Vision. Photography- Photoimaging, and PhotochromismCourse Outcome: It will enable the student to get deep knowledge of pericyclic reactions. The student will be able to apply different concept like FMO and PMO epproach to cycloaddition, electrocyclic reaction and sigmatropic reactions. The student will gain the insight into photochemistry of alkene, carbonyl compounds. The get the basic idea of Photochemistry of Vision, Photography- Photoimaging, and Photochromism Instructions for paper setter: ‘Time of Examination: 3 Hours. The Question paper is divided in to two sections A and B, both compulsory. Section A comprises of 12 questions (3 fromeach unit) of one mark each. Section B comprises of 4 questions (1 from each unit with two alternatives) of 12 markseach. ‘Text/Reference Books: 1. K KRohtagi-Mukherji, Fundamentals of Photochemisry, Wiley Eastem 2. RPKundall and A Gilbert, Photochemistry. Thomson Nelson. 3. L.Coxon and B Halton, Organic Photochomishy, CambridgeUniversity Press. 4. A.Cox and T.Camp, Introductory Photochemistry, McGraw Hill. 5. SM. Mukherji, Pericyclic Reactions, Macmillan, India 6. JSingh and L.D.$ Yadav. Advance Organic Chemisty. Pragati Prakashan, Meerut. 7. HO. House, Modern Organic Reactions. 2% Edition (1972), Benjamin/Cummings Publishing Company, Califomia‘MSc. (3rd Semester) Chemistry ‘MCH.303 (Advanced Physical Chemistry) Lo oT P Continuous evaluation 40 4 o oo Endsemester exam 00 Total marks 100 Credits 40 Course Objectives: The course intends to impart knowledge on advanced concepts of electrochemistry. To leam about the batteries and fue! cell, types of polaisation etc. To impart student the knowledge of principle and mechanism of comosion. To understand about micelles and emulsions. Students will get exposure of the understanding of liquid-gas and liquid interfaces and electrical double layer UNITI Advanced Electro Chemistry: Ton solvent interactions and electrolysis: Tae Bora model and expression for the free energy of ion — solvent interactions. Batteries and Fuel cells: significance of Fuel cells, Hydrogen — oxygenand natural g2s.air, and carbon monoxide fuel cells, air fnel cells. Electrolysis: Decomposition potential, calculations and detenninations Polarization: types of polarizations, over voltage and hydrogen and oxygen over veltage. UNIO Corrosion: Introduction of corrosion, Types of corrosion, pilling - Bed worth rule of corrosion, corrosion of metal and expression for comosion rates, passivity, electrochemical theory of corrosion, polarization of electrodes, anodic and cathodic polarization curves, Prevention of corrosion, Stem-Geary equation, principles of anodic and cathodic protection. UNIT Micelle: Surface activity, surface active agents and their classification, micellisation, critical micelle concentration (cmc) thermodynamics of micellation, factors affecting cme, reverse micelle, solublisation of water insoluble organic substances, and use of surfactants in cil recovery. Emulsion: Types of emulsion, theozies of emulsion stability, identification of emulsion types, inversion emulsion, micro emulsion: theory and application. UNITIV Liquid-Gas and Liquid Interfaces: Surface tension, capillary action. method of determination of surface tension. surface tension across curved surfaces, vapor pressure of droplet (Kelvin equation),surface spreading coefficient, contact angle, constant angle hysteries, wetting and detergency. Electrical Double Layer:Helmholtz-Perin theory, Gouy-Chapman theory, Stem’s theory, Quantitative treatment of Zeta potential, “Measurement of Zeta potential by electrophoresis, Importance of Zeta potential ‘Course Outcome: On completion student will be able to discuss Bom model and expression for the fiee energy of ion-solvent interactions; about batteries and fuel cells; electrolysis and polarization. They will gain kmowledge on types, mechanism and prevention of corrosion. They will have enough Amowledge on concept of micelles and emulsions ete. Instructions for paper setter: ‘Time of Examination: 3 Hours. The Question paper is divided in to two sections A and B. both compulsory. Section A comprises of 12 questions (3 from each unit) of one mark each. Section B comprises of 4 questions (1 from each unit with two altematives) of 12 marks each. ‘Text/Reference Books: 1. V. Morci, Micelles, Theoretical and Applied Aspects, Plenum. S. Glassione, Electrochemistry, Affiliated East-West Press IM. Hollas, Modern Spectroscopy, John Wiley. PW. Atkins, Pipsical Chemistry, ELBS TOM Bockris and AK. Reddy. Modern Electrochemistry Vol. I and Vol. I Plenum. S.J.Gregg: “The Surface Chemistry of Solids”, Chapman and Hall N.K.Adam: “The Physics and Chemistry of Surfaces”, OxfordUniversity Press ea aa‘MSc. (3rd Semester) Chemistry Reagents and Heterocyclic Chemistry MCH-304 Lo oT P Continuous evaluation40 4 an) End semester exam 60 Total marks 100 Credits 40 Course Objectives: The objective of this course is to provide an opportunity to develop understanding of reagents used in organic synthesis. To study the detail of some rearrangement reactions. To learn the chemistry of aliphatic and aromatic heterocyclic compounds. UNIT Reagents in Organic Synthesis, Preparation, properties and applications of the following in organic synthesis with mechanistic details- Lithium diisopropylamide (LDA), Dicyciohexylcarbodiimide(OCC).1,3-Dithiane(reactivity ‘umpolong), ‘Ttrimethylisilyliodide, osmium teraoxide, DDQ selenium dioxide, phase transfer catalysts(crown ethers), AD-mix-a and AD-mix-B reagents, Wilkinson's catalyst. Grubbs catalyst. iodobenzene diacetate, Gilmen’ s reagent. UNIT Name Reactions & Rearrangements A detailed study of the following rearangements- Demjanov, Favroskii, Amdt-Eistert synthesis, Neber, Bacyer-Villiger, Shapiro reaction, Hoffimann-Loffer-Fretag reaction, Chichibebin reaction. Heck reaction, Mitsunobu reaction, Suzuki cross-coupling, Sonogashira cross-coupling. Peterson's synthesis Chapman Rearrangement. UNIT Heterocyclic Chemistry Aromatic Heterocycles: General chemical behavior of aromatic heterocycles, nomenclature (structural type), criteria of aromaticity, bond length, ring cuent and chemical shifts in 'H NMR. spectra, empirical resonance energy, Non-aromatic Heterocycles: Strained bond angle and torsional strain and their consequences in small ring heterocycles. Conformation of six membered heterocycles with references to molecular geometry, bamtier to ring inversion, pyramidal inversion and 1. 3- diaxial interaction. Attractive interactions — hydrogen bonding UNIT Heterocyclic Synthesis (three, four and benzofused five membered): Three membered rings- synthesis and reactions of aziridines, oxiranes, and thiiranes. Synthesis and reactions of indoles, oxazoles, pyrazoles and thiazoles. Six membered Heterocycles with one, two or more heteroatoms: Synthesis and reactions of pyrylium salts and pyrones . Synthesis of pyrimidines and purines.Course Outcome: At the end student will be able to discuss about the preparation, properties and applications of the different organic reagents. They get knowledge of many name reactions and some rearrangement reactions. They get deep insight into the heterocyclic chemistry of compound containing 3,4, Sand 6 membered ring with hetero atoms. Instructions for paper setter: Time of Examination: 3 Hours. The Question paper is divided in to two sections A and B, both compulsory. Section A comprises of 12 questions (3 fromcach unit) of one mark cach. Section B comprises of 4 questions (1 ‘from each unit with two alternatives) of 12 markseach. Text/Reference Books:: 1. J.Mann, RS. Davidson, 1B. Hobbs, D.V. Banthrope and J. B. Harborne, Natural Products: Chemistry and Biological significance. Longman, Essex. 2. LLFinar, Organic Chemisry, Vol-D, 5® Edition, Longman Ltd. New Delhi, 1975 3. Fieser and Fieser, Reagents in Organic Synthesis, Wiley 4. FA Carey and RL Sundberg, Advanced Organic Chemistry, Part-B, 3rd Edition, Plenum Press, 1990. 3. RK Bansal, Heterocyclic Chemisty: Synthesis, Reactions and Mechanism, 34 Edition, 1999 6. TL Gilcmist, Heierocyclic Chemisty, 34 Edition, Addison-Wesley Longman Ltd, England 1997 ‘R.RGupta, M. Kumar and V. Gupta, Heterocvclic Chemisny, Vol. 1-3, Springer Verlag 8. IA Joule, K. Mills and GF Smith, Heterocyclic Chemisty, Chapman and Hall, 9. ARKauitzky and CW. Rees, Comprehensive Heterocyclic Chemistry, eds. Pergamon Press. 10. J. Fhrhop and G.Penzillin, Organic Sinthesis- Concept, Methods and Starting Materials. Verlag VCH, 11. FA. Carey and RJ. Sundburg, Advanced Organic Chemistry-Part B, Plenum Press.‘MSc. (@rd Semester) Chemistry ‘MCH_305(norganic Chemistry Practical ITT) Lot P Continuous evaluation 60 0 o 6 Endsemester exam 40 Total marks 100 Credits 30 Course Objectives: Tae objective of this course is to provide students with an opportunity to develop skills in doing experiments of separation and determination of two metal ions involving volumetric and gravimetric methods. The student will also develop skills in quantitative analysis of elements or groups in the complexes, mixtures, ores, alleys. L Quantitative Analysis 1. Separation and determination of two metal ions such as Ag-Cu, Cu-Ni, Cu-Zn, Ni-Zn, CuFe, Fe-Mg etc. involving volumetric and gravimetric methods. 2. Quantitative analysis of elements or groups in the complexes, mixtures, ores, alloys ete. by available analytical techniques like gravimetry.volumetry and complexometry. II. Lab Record and Viva Voce. Course Outcome: On successful completion of the course, the students will be able to separate and determine two metal ions such as Ag- Cu, Cu-Ni, Cu-Zn, Ni-Zn, Cu-Fe, Fe-Mg etc. involving volumetric and gravimetric methods. They will be able to perform quantitative analysis of elements or ‘groups in the complexes, mixtures, ores, alloys by available analytical techniques. Text/Reference Books: 1. A Text Book of Micto and Semi —micro quantitative analysis, A.I-Vogel, Orient Longman. 2. A Vogel’s Text Book of Quantitative Inorganic Analysis, Bassett, RC Demey. GB. Jaffery and J. Menaham, Longman, London.‘MSc. (3rd Semester) Chemistry ‘MCH-306 (Organic Chemistry Practical- ITT) Lo oT P Continuous evaluation 60 0 o 6 Endsemester exam 40 Total marks 100 Credits 30 ‘Time of Examination: Six Hours (Two Sessions each of three hours) Course Objectives: To develop skills in the systematic analysis of a binary organic mixture, To analyse these organic mixtures and confirm their structures. To provide the skill to extract the organic ‘compounds from some natural source. 1. Qualitative Analysis: Systematic analysis of binary organic mixture Golid+solid; liquidHiquid) including separation by chemical analysis and confirmation of their structures with IR and PMR spectral data (IR and PMR spectra to be provided). 2. Extraction of Organic compounds from natural source: Isolation of caffeine from tea leaves. Isolation of casein from milk. Isolation of lactose from milk. Isolation of B-carotene from tea carrots. 3. Lab Record and Viva -Voce. Note: Any other practical may be introduced. ‘Course Outcome: At the end of the course. the students will be able to analysis the binary organic mixture (sclid + solid; liquid + liquid) including separation by chemical analysis and confirmation of their structures with IR and PMR spectral data. The students will get an experience to isolate the ‘organic compound from natural source. TextlReference Books: 1. A Handbook of Organic Analysis-Qualitative and Text Book of Macro and Semi-micro Quantitative Analysis, AI Vogel, Orient Longman. 2. A Vogel's Text Book of Quantitative Inorganic Analysis, J. Bassett, R.C. Denney, G.B. Jaffery and J. Menaham, Longman, London. 3. Systematic Qualitative Organic Analysis by H. Middleton, Edward Amold @ublisher) Limited, London 1959. 4. Elementary Practical Organic Chemistry by Arthur | Vogel, EXCBS Publishers and Distributors. Experiments in Organic Chemistry by Louis, F Fieser, D.C. Heath and Company Boston, 1955 6 Organic Analytical Chemistry by Jag Mchan, Narosa Publishing House.‘MSc. (3rd Semester) Chemistry ‘MCH. 307 Physical Chemistry Practical- ITT) Lo oT P Continuous evaluation 60 0 o 6 Endsemester exam 40 ‘Total marks 100 Credits 30 ‘Time of examination: 6 Hours ‘Course Objectives: To student will leam the technique of drawing binary and temary phase diagram. They will get hand on experience of analyzing rate constant of some reactions. To perform some experiment on refractrometry. To leam some experiments based on complexometry, viscometry and spectrophotometry Phase rule 1. Temary Phase diagram of a water, benzene, and acetic acid. 2 Phase diagram of 2 binary organic system ( Nephthalene and Diphenyl) 3. To determine the composition and smount of thelayers obtained by mixing 50 g of phenol with 50 g of water at 40°C. ‘Chemical Kinetics 4 Equilibrium constant of KI+h = KI: by distribution constant. 5 Analysis of halide mixture by differential potentiometry. 6 Rate constant of acid catalyzed hydrolysis of sucrose by chemical method. 7 Kinetics of KIwith persulphate and study of salt effect. Refractometry & To determine therefractive index of ethyle alcohol by Abbe refactometer and find specific and molar refraction. 9 To determine themolar refractivity and to calculate the refraction equivalents of C & H atom to show constancy of CH. 10 To determine the refractive index of a series of different conc. of KCl and hence determine the composition of unknown solution of salt. Complexometry and viscometry 11 Study of complex formation by Job’s method. 12 Detemnination of molecular weight of a polymer Polystyrene) by viscosity measurementSpectrophotometry 14 To titrate the solution of HC! with NaOH spectrophotometrically. 15 Veiification of Beer Lambert law. LABRECORD & VIVA-VOCE Any other experiments can be introduced in the class Course Outcome: It will enable the students to get deep understanding of application of phase mule. The students will get nowledge of studying kinetics of various reactions. They will be able to determine the refractive index of different unknown solution. Student will understand the determination of M.wt of polymer and Spectrophotometric titration. ‘Text/Reference Books: 1. Practical Physical Chemistry, A.M. James and Prichard, Longman. Finfley’s Practical physical Chemistry, BP. Lavitt, Longoman. Practical physical Chemistry, SR Palit and §.K. De, Science. Experimental physical Chemistry, R.C. Das and B. Behra , Tata McGraw Hill Advanced Practical physical Chemistry, JB. Yadav. Goel Publishing House Experiments in physical Chemistry, DP. Shoemaker. 7. Experiments in physical Chemistry, D. V. Jahagirdh n awe