College of Nursing
DRUG STUDY
Side Nursing Monitoring
Name of Drug Classification Indication Contraindication effects/Adverse Implications Parameters
Effect
• Observe the • Monitor
Generic Name: Anti-gout agent CNS: 12 rights of Complete
Colchicine Anti-inflammatory Colchicine is used to Colchicine is Headache, medication blood count
prevent gout attacks contraindicated to Neuropathy, (CBC): This
administratio
test checks the
Brand Name: Mechanism of (sudden, severe pain in patients who have Peripheral neuritis n.
levels of red
Mitigare action: one or more joints hypersensitivity to the • Double blood cells,
Tubulin disruption. caused by abnormally drug, pregnant GI: Gastrointestinal check the white blood
Dose and This leads to high levels of uric acid in women, patients hemorrhage, physician's cells, and
Frequency: subsequent down the blood) in adults. undergoing diarrhea, nausea, order platelets.
BID regulation of Also, to relieve the pain hemodialysis, patients vomiting including the Colchicine can
multiple of gout attacks when with severe renal Integ: time, dosage, cause bone
Dose: inflammatory they occur. impairment, and those Alopecia, Rash route, and marrow
650mcg pathways and with renal or hepatic frequency. suppression,
which can lead
modulation of impairment taking p Musculoskeletal: • Verify the
to a decrease
Route: innate immunity. Glycoprotein drugs or Myotonia, Muscle patient' in all three
PO CYP3A4 inhibitor weakness, identity using types of blood
Myopathy at least 2 cell.
Repro: patient • Liver function
Amenorrhea, identifiers. tests (LFTs):
Dysmenorrhea, These tests
Oligospermia, • Check the measure the
Azoospermia expiration levels of
date of the enzymes and
other
Respi: drug.
substances
Pharyngolaryngeal • Check the
produced by
pain medical the liver.
history of the
patient. Colchicine can
Potentially • Obtain the cause liver
Fatal: patient's damage, so it
Severe bone laboratory is important to
marrow results for monitor LFTs
depression, to detect any
baseline and
signs of liver
Respiratory periodic
toxicity.
distress syndrome determinatio • Kidney
ns of serum function tests
uric acid and (KFTs): These
creatinine, as tests measure
well as CBC, the levels of
including waste
Hgb, platelet products in the
count, serum blood that are
filtered out by
electrolytes,
the kidneys.
and
Colchicine can
urinalysis. cause kidney
• Ensure that damage, so it
the patient is important to
does not monitor KFTs
have any to detect any
contraindicati signs of kidney
toxicity.
ons to the .
drug, such as
patients with
renal or
hepatic
impairment
who are
taking a P-gp
inhibitor or a
strong
СУРЗА4
inhibitor and
Hypersensitiv
ity to the
drug.
• Watch out for
drug
interactions,
such as
Antifungals,
Antibiotics,
and
Antidepressa
nts since
these raise
the risk of
adverse
effects or
severe
muscle
change.
