Introduction of The New 5975 Inert MSD For Expanding Your Application Capabilities

5975 inert MSD
Chris Sandy
European GC-MS Product Specialist
Agilent Technologies
Welcome to our e-Seminar:
Introduction of the new 5975 inert MSD for

expanding your application capabilities
Presenter: Chris Sandy

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What Has Changed?
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What’s the same?
• Reliability
• Quality
• Inertness
But NOT Performance – it’s better!

Chairperson: John Vis, Audio: +44 207 162 0125 Slide 3
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What’s Different?
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• Functional industrial design
• More efficient vacuum system
• Extended mass range
• AutoCI
• New sensitivity specifications
• Synchronous SIM/Scan
• EI with CI ion source
• 6850 GC control
• QuickSwap MSD interface
• Review of differentiators

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Quick Remove Top Cover
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Easy analyzer access

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Functional Front Window
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• Wire connections
• Filament operation
• Column insertion
• CI Source identification
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Modified Mainframe
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Modified MSD mainframe
for quick/easy turbo pump
maintenance
New turbo and mechanical vacuum
pumps are more efficient for Helium
and Hydrogen
• New 70 L/sec standard pump
• New 262 L/sec performance pump
• New 2.5 m3/hour mechanical pump
(67% more capacity)

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Integrated Ion Gauge/Controller
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• Greater vacuum
precision
• Excellent for trouble

shooting small leaks –
every system should
have one!
G3397A – optional gauge/controller
Local display Software display

New Sensitivity Specifications –
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EI Scan
5973 5975
EI 60:1 100:1
1 pg OFN
182:1 s/n

New Sensitivity Specifications –
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CI Scan
5973 5975
PCI 75:1 125:1
100 pg BZP
NCI 500:1 300:1
704:1 s/n
1 pg/100 fg (1 pg) (100 fg) (100 fg OFN under NCI)
OFN

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Extended Mass Range
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• 1050 m/z for 5975 inert MSD
• Quadrupole modified
• New electronics
• 800 m/z for all 5973 MSDs

(Software upgrade does not enable 1050 m/z)

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Extended Mass Range – PBDE 209
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Extended Mass Range –
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PBDE 209
959 959
957
957
961
961
955
955
963
963
953
965 953
965
960 962 960
958 962
956 958
956 964
954
953 954 955 956 957 958 959 960 961 962 963 964 965
5975 inert MSD Theoretical

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AutoCI
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• AutoCI – Fully automated setup/tuning
• No external manual control
• CI made as easy as EI!
The new 5975 The old 5973 manual

CI interface CI interface
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Automated EI with CI Source
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• March 2004: 5973 MSD
• Application note on EI with CI ion source
5989-0595EN
• Now: 5975 MSD

• Automated switching between EI and CI in a
sequence

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Automated EI with CI Source
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Setup steps:
1. Install CI Source
2. Tune instrument in PCI – create PCICH4.u
3. Auto create EI tune file – create ei-cisource.u
4. Tune instrument in NCI – NCICH4.u
5. Assign tune file with method and run in
sequence

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6850 GC Control via
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ChemStation
• 5973N MSD (G2570A)

• 5973 inert MSDs
• 5975 inert MSDs

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Agilent MSD Unique Features
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• Inert Ion source
• Hyperbolic quad
• Quad temp
• CI system
• Analyzer modularity

Synchronous SIM/Scan
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Set Up Synchronous SIM/Scan
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• SIM/Scan data
analysis requires
mixed mode data
view.
• SIM/Scan data is
saved in the same
data file directory.

Comparison of SIM/scan
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Implementations
Implementation (1) – ‘coarse granularity’
Implementation (2) – ‘fine granularity’ at specific times
Agilent Implementation– ‘fine granularity’ for whole

acquisition time
TIME 11.20 11.40 11.60 11.80 12.00 12.20 12.40 12.60 12.80 13.00 13.20 13.40
Scan SIM

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Synchronous SIM/Scan –
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AutoSIM
• AUTOSIM is a standard feature of G1701DA Software
• AUTOSIM provides rapid and automatic conversion of a Scan

method to SIM/Scan
• AUTOSIM creates SIM method based on Calibration table
• The operator has fine control over SIM parameter settings
• The SIM ions/groups/times are saved automatically to the

method

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Inject Standard
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AutoSIM
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Application note: 5988-4188EN
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Edit SIM Method
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AutoSIM automatically creates SIM groups and
populates ions in each group

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Scan and SIM Chromatograms from
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SIM/Scan Analysis of 60 VOCs at
1 ppb Each
TIC: 1 ppb 60 VOCs.D\DATA.MS
130000
Scan110000
90000
70000
50000 • Velocity XPT/6890N/5975

30000
P&T/GC/MS system
10000
1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.0011.0012.0013.00
• 20-m X 0.18 mm X 1.0 µm
TIC: 1 ppb 60 VOCs.D\DATASIM.MS
DB-VRX column
90000
• Scan sampling rate = 2;
SIM Dwell =20 ms for SIM
70000
50000
30000
10000
1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.0011.0012.0013.00

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Synchronous SIM/Scan Analysis of
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VOC Target Gases at 1 ppb each
10000
1 Scan
9000 6
8000
2 3 VOC Gases (1 ppb each)
7000
6000
5000
4 5 1. Dichlorodifluoromethane
4000
3000
2000 2. Chloromethane
1000
0 1.20 1.30 1.40 1.50 1.60 1.70 1.80 1.90 2.00
3. Vinyl chloride
1 SIM
10000 6 4. Bromomethane
9000
8000 2 3
7000
6000 4 5 5. Ethyl chloride
5000
4000
3000
2000
6. Trichlorofluoromethane
1000
0
1.151.20 1.25 1.30 1.35 1.401.45 1.50 1.55 1.601.65 1.70 1.75 1.80 1.851.90 1.95

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SIM/Scan and Scan-Only Sensitivity
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Comparison: 5-mL Purge of 1 ppb
Ethyl Chloride (a Low Responding Gas)
Peak/Peak
RMS S/N
S/N
SIM
749 254
(SIM/Scan)
Scan
75 20
(SIM/Scan)
Scan
73 17
(Scan only)
• SIM as part of SIM/Scan run gives 10X greater sensitivity
• Still get ≥ 8 scans across peak using same scan rate (n = 2)

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Why Our SIM/Scan is So Good
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Standard Electronics Performance Electronics
100 21 22
100
23 ~ 781 amu/sec 23 ~ 781 amu/sec
22
20 ~ 6250 amu/sec
Nearly no fall off
21 Fall off with with increasing scan
increasing scan speed
speed
50 50
20 ~ 6250 amu/sec
Moving from 23 to 22
doubles scans
Phenanthrene Phenanthrene

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Scan SIM/scan
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1 sec 2 sec
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Scan 45 to 555 => 510
amu
45 to 555 amu, Scan
only @ 2^2
1563 amu/s 2.87 scan/sec
a cycle
SIM
2^0
6250 amu/s
4 ions, 40 ms 3.76 cycle/s
Same width (SIM)
2^1
3125 amu/s
2.88 cycle/s
2^2
1563 amu/s
1.94 cycle/s
For a 0.25 mm column, a typical peak width (at base) is 6 seconds. Switch from scan at 2^2 mode to
SIM/scan@2^1, there will still be the same 15 cycles over the peak, but gets the 4-ion SIM group data for
FREE.
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Key Features
• Performance Electronics really make the difference
• SIM Improvements – 100 groups and 60 ions per group
• Minimum dwell time is reduced by half to 5 ms

• Even more data points per SIM peak
• Synchronous SIM/Scan available on 5973 MSDs with

performance electronics (req. Smart Card 3+)
• Upgrades: G1088A and G1088B AND SW upgrade

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Application examples
•Allergens analysis: Proposed 5975 method, 26 Targets

SIM/Scan mode
- SIM table built with AUTOSIM

- Quant with SIM target ion
- Confirmation by DRS with Scan data
•Pesticides analysis with microfluidics technology for

flexible GC and GC/MS analysis

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Allergens analysis in SIM/Scan
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After shave
1% v/v 1ul Split 20 : 1
SCAN
SIM

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Allergens Overlaid SIM/Scan
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Allergens SIM/Scan analysis and
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deconvolution with DRS
Quant based on SIM

target ion
Confirmation based
on deconvoluted
full mass spectrum
With courtesy of Chris Sandy and J-F Garnier

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Summary
• Great for target analysis and identifying

unknowns
• SIM data for quantitation
• Scan data for confirmation of unknowns
• Our SIM/Scan delivers real performance based

on superior electronics

Overview of Microfluidic
Technologies
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Connections to Microfluidic Splitter
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To Detector 2 To Detector 1 Column
Nut
Metal
Ferrule
Channel
Plate
•Deactivated, very low internal volume to prevent peak tailing or
band broadening
•A single, special design metal ferrule
• More inert that graphite/vespel, does not leak at high oven

temperatures
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Microfluidic Splitter hardware
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installation
Deactivated microfluidic
splitter operates to 350 C.
Uses metal ferrules to
eliminate leaks and
retightening
Makeup from
Aux EPC
Column in
To Det 1
To MSD

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Microfluidic Splitter operating
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modes * (1) Single Column
AUX EPC
Blocked
Column in
MSD
* Aux EPC Flow enables column change-over without venting MSD

* Aux EPC Flow enables inlet / septum maintenance without ingress
of air into column.
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modes (2) Splitter
AUX EPC
Column in
Detector 1
MSD

of air into column.
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Splitting to 2 Detectors
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Configuration for 2:1 Split to MSD
Auto- Effluent Splitter
sampler AUX EPC
mECD with Makeup
3.8 psig
0.814 m X
0.18 mm id
5975 Inert
Column 1.1 m X
0.18 mm id
MSD
6890N 15 m X 0.25 mm id X 0.25 um HP-5MS

GC

Microfluidic Splitter
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– ‘Chromatographically Transparent’
MSD
ECD

100 ppb VOAs, 100 ppm Gasoline in
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Water, Ambient Headspace
Scan
0 2 4 6 8 10 12
SIM
0 2 4 6 8 10 12
ECD
0 2 4 6 8 10 12

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modes :(3) Dual Column Inlet
AUX EPC
Column 1 / Inlet 1
Column 2 / Inlet 2
MSD

of air into column.
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Dual Column Configuration*
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Back : 30m x 0.25mm ID x 0.25um HP5-MS 25 mins
Front : 12.4m x 0.25mm ID x 0.25um HP5-MS

6 mins
*Requires performance turbo pump

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Microfluidic Splitter operating modes :
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(4) Dual Column Inlet + Olfactory Port + MSD
AUX EPC
Column 1 / Inlet 1
Column 2 / Inlet 2
MSD
ODO II
of air into column.
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Microfluidic Splitter operating modes *
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(5) Splitter mode with Backflush
Splitter mode – acquiring data
AUX EPC
3.8 psig Column inlet
23.73 psig
Detector 1
MSD
Backflush mode
AUX EPC
25.0 psig Column inlet
1.0 psig
* Aux EPC Flow enables column
Detector 1
change-over without venting MSD
* Aux EPC Flow enables inlet / septum
maintenance without ingress of air into MSD
column
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6890N/5975 inert Pesticide Analysis
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with 3-Way Splitter
1X method with 10:10:1 split FPD:MSD:ECD
Phosphorus FPD
Auto-sampler
3-way Effluent
Splitter with
AUX EPC uECD
3.8 psig
Makeup
5975
Column Inert
MSD
6890N
GC 30 m X 0.25 mm id X 0.25 um HP-5MS

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1-injection-4-signal System
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• 5975, RTLocked, 30m x 0.25mm x 0.25um HP-5MS
• Samples: pesticide mix at 10, 1, and 0.1 ppm
• Injection: 10:1 split
• At the end of the column, eluent flow is split 3 ways:

MSD:FPD:µECD = 10:10:1
Injection
10 ppm (10000 pg) ~480 pg SIM/Scan
1000 pg ~48 pg µECD
10:1
~480 pg
split FPD

5975 SIM/scan + 3-way splitter
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Ultimate Pesticide System
Scan: ~ 480 pg
SIM: ~ 480 pg
µECD: ~ 48 pg
FPD: ~ 480 pg
7 peaks
5.00 10.00 15.00 20.00 25.00 30.00 35.00 40.00 45.00

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QuickSwap MSD interface
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Available October 1st, 2005
• Replacement for NoVent Column
• Remove column w/o venting
• Backflush mode MS
Transferline
• Inlet maintenance reverse flow
EPC inlet
• Removes heavies from column
• Maintain constant flow to MSD Microfluidic technology
Requires performance turbo for flow rates > 2 cc/min

Introduction to
eMethods and the new
MSD Chemstation
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What are eMethods?
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• eMethods is short for
Electronic Methods.
• Can now package existing

GC/MSD methods
• Export them to other 5973 MSDs
• Export them to 5975 inert MSDs

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eMethod Benefits
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• Fast setup of new 5975 inert
MSD
• Method sharing between

5973 and 5975 MSDs
• Download apps from website

and import entire method into
MSD ChemStation

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New 5975 inert eMethods
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• PBDE Flame Retardants
• SIM/Scan – Pesticides in Water and Food
• VOCs via Headspace – European method
• Residual Solvents via Headspace
• NIDA Drugs

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MSD ChemStation Software
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• Two GC/MS per • eMethods
ChemStation
• Four configurations
• GC and GC/MS control
• Enhanced mode
• Retention time locking • EnviroQuant
• DrugQuant
• Custom reports
• Reformulated Gas
Most popular GC/MS software in the world

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Instrument Control
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Enhancements
• Combined Top/Instrument Control Screen

• New icons for quick access to tune, EMF and print
• Configurable sequence table
• More right mouse click functions in editing sequences
• Printing selected sections of method and sequence
• Import of GC ChemStation method parameters
(excluding 5890 GC)
• Display of IP address(s) of GC and MSD instruments

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Data Analysis Enhancements
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• Explorer-style navigation tool
• Interactive editing of Integration Parameters
• Switchable right mouse click functions
• Spreadsheet-like SIM Parameters Table
• Icons for custom tools, DA options, variable watch
• Toolbar on/off capabiity
• Selectable DA color themes

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Data Analysis Enhancements
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•QEdit functionality is improved:
• Separate window for Baseline Display
• Generating reports directly from QEdit
• Custom configuring X-axis

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Explorer Navigation
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Explorer navigation

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Interactive Edit Integration
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Right Click Features
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SIM Parameter Table
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QEdit
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Baseline Display
Reports

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Library Options
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• NIST05 NEW
• Wiley 7th ed
• Stan pesticide
• Pfleger/Maurer/Weber MS Drug Library, 3rd ed
• NIST Chemical Structures Library

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Other Software Options
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• Deconvolution Reporting Software
- New Revison A.02 released Aug 1, 2005
• Security ChemStation
• Headspace software
• RTL Pesticide Database : FAMES, Flavors,

Volatiles Organics, Organotin derivatives, PCB
congeners, Forensic toxicology

Expanding the portfolio of
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RTL / DRS Databases
• Updated RTL Pesticides Database, Nov 2005
Adding ~ 200 new compounds
• TIC Toxic Industrial Chemicals Database, Nov 2005
~ 800 compounds (VOC, SVOC, Dioxins, PCBs and

Pesticides)

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GC/MS Configurations
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• 5973N EI with diffusion pump
• 5975 inert EI with standard turbo pump
• 5975 inert EI with performance turbo pump
• 5975 XL EI/PCI/NCI with performance turbo pump
All systems available with choice of either 6850 or 6890 GCs

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Summary
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Agilent 5975Inert MSD
• Better reliability and quality
• Enhanced performance
• eMethods
• AutoSIM and SIM/scan
• Higher mass range
• AutoCI
• Sensitivity
• Software improvements

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Wrap-up E-Seminar Questions
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Thank you for attending today’s Agilent e-Seminar.
Our e-Seminar schedule is expanding regularly.
Please check our web site frequently at:
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Introduction of The New 5975 Inert MSD For Expanding Your Application Capabilities

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Introduction of The New 5975 Inert MSD For Expanding Your Application Capabilities

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5975 inert MSD

Introduction of the new 5975 inert MSD for

Presenter: Chris Sandy

But NOT Performance – it’s better!

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• Excellent for trouble

Local display Software display

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• 800 m/z for all 5973 MSDs

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The new 5975 The old 5973 manual

• Now: 5975 MSD

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• 5973N MSD (G2570A)

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Implementation (2) – ‘fine granularity’ at specific times

Agilent Implementation– ‘fine granularity’ for whole

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• AUTOSIM provides rapid and automatic conversion of a Scan

• AUTOSIM creates SIM method based on Calibration table

• The operator has fine control over SIM parameter settings

• The SIM ions/groups/times are saved automatically to the

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50000 • Velocity XPT/6890N/5975

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• Performance Electronics really make the difference

• SIM Improvements – 100 groups and 60 ions per group

• Minimum dwell time is reduced by half to 5 ms

• Synchronous SIM/Scan available on 5973 MSDs with

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•Allergens analysis: Proposed 5975 method, 26 Targets

- SIM table built with AUTOSIM

•Pesticides analysis with microfluidics technology for

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Quant based on SIM

With courtesy of Chris Sandy and J-F Garnier

• Great for target analysis and identifying

• Our SIM/Scan delivers real performance based

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•A single, special design metal ferrule

• More inert that graphite/vespel, does not leak at high oven

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* Aux EPC Flow enables column change-over without venting MSD

* Aux EPC Flow enables column change-over without venting MSD

6890N 15 m X 0.25 mm id X 0.25 um HP-5MS

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* Aux EPC Flow enables column change-over without venting MSD

Front : 12.4m x 0.25mm ID x 0.25um HP5-MS

*Requires performance turbo pump