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European Journal of Trauma and Emergency Surgery (2020) 46:187–195

https://doi.org/10.1007/s00068-018-1021-9

ORIGINAL ARTICLE

Comparison of thick- and thin-slice images in thoracoabdominal


trauma CT: a retrospective analysis
Leon Guchlerner1 · Julian Lukas Wichmann1 · Patricia Tischendorf1 · Moritz Albrecht1 · Thomas Josef Vogl1 ·
Sebastian Wutzler2 · Hanns Ackermann3 · Katrin Eichler1 · Claudia Frellesen1

Received: 1 May 2018 / Accepted: 25 September 2018 / Published online: 28 September 2018
© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Abstract
Purpose To compare thick (5 mm) and thin slice images (1.5 mm) of lung, soft tissue, and bone window in thoracoabdominal
trauma computed tomography.
Materials and methods 167 Patients that underwent thoracoabdominal trauma CT between November 2014 and December
2015 were included in the study. CT data were reconstructed in a transverse direction with 5 mm and 1.5 mm slice images
of lung, soft tissue, and bone window. Two blinded raters (radiologists) evaluated the collected data by detecting predefined
injuries in different organ areas. Reconstruction and evaluation times as well as detected injuries were noted and compared.
Results Reconstruction and evaluation times were significantly higher with 1.5 mm thin-slice images, and the effect strength
according to Rosenthal displayed a strong effect of 0.61 (< 0.1 small effect, 0.3 middle effect, and > 0.5 strong effect). Average
evaluation time differences were 62.7 s (33.9 s–91.5 s) in bone window between 1.5 mm and 3 mm for rater 1 (p < 0.001) and
71.4 s (43.1 s–99.7 s) for rater 2 (p < 0.001). Average time differences between 1.5 mm and 5 mm were 68,7 s (43.9 s–93.5 s)
for rater 1 and 75.3 s (44.7 s–105.9 s) for rater 2 in lung window (p < 0.001) and 66.6 s (28.8 s–104.4 s) for rater 1 and 114 s
(74.4 s–153.6 s) for rater 2 in soft-tissue window (p < 0.001). There was no significant difference regarding soft-tissue and
lung injuries, except non-significant improvement in the detection of bone fractures.
Conclusion Thin-slice images do not bring any significant benefit in thoracoabdominal trauma CT of soft-tissue and lung
injuries, but they can be helpful for the diagnosis of bone fractures and incidental findings.

Keywords Trauma · CT diagnostic · Soft tissue · Bone · Slice thickness

Introduction to reveal concealed internal, potentially life-threatening


trauma. Radiologic diagnostics including conventional
Accident-related trauma is one of the most common causes X-ray, sonography, and CT is beneficial in this context [2–4].
of death for young adults in Germany [1, 2]. A detailed and Whole-body computed tomography (WBCT) is gaining
quick diagnostic measure is, therefore, of high importance importance in primary diagnosis of inner organ injuries by
quick detection [5, 6]. It allows a highly sensitive evaluation
method to assess the aftermath of life-threatening accidents
* Leon Guchlerner [7–9]. Meanwhile, it has become a standard procedure for
leon.guchlerner@gmail.com hemodynamically stable patients [10].
1 The early usage of CT-supported imaging demonstrably
Department of Diagnostic and Interventional Radiology,
Institut fuer Diagnostische und Interventionelle increases the survival time of polytraumatized patients [11].
Radiologie, Clinic of the Goethe University, Haus 23C UG, For the evaluation of trauma sequelae, there are different
Theodor‑Stern‑Kai 7, 60590 Frankfurt am Main, Germany slice thicknesses available for different organ areas [12–14].
2
Department of Trauma, Hand and Reconstructive Surgery, They differ in amount of picture data and evaluation time,
Clinic of the Goethe University, Theodor‑Stern‑Kai 7, which impacts on clinical practice and handling of trauma
60590 Frankfurt, Germany patients [15]. A crucial factor in dealing with polytrauma-
3
Department of Biostatistics and Mathematical Modelling, tized patients is to find hidden life-threatening injuries (e.g.,
Clinic of the Goethe University, Theodor‑Stern‑Kai 7, internal bleeding of unknown origin) as fast as possible and
60590 Frankfurt, Germany

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188 L. Guchlerner et al.

to initiate immediate action. Longer evaluation times may and lung window and 3 mm for bone window as in-house
be obstructive in this emergency situation. Thin slices often standard. In addition, thin-slice axial images with 1.5 mm
find usage in extended exploration of small cysts, tumor were deployed as experimental for all window settings.
classification, and for seeking metastases [16–19], whereas Table 1 gives an overview of reconstruction parameters.
thick slices are normally utilized for the swift detection All planes and slice thicknesses were calculated out of raw
of trauma and other pathologies [17]. The question arose image data from a scan in a mixed phase with a collimation
whether thin- or thick-sliced computed tomography gives of 0.6 mm. 5 mm slices were calculated standardly out of
better results in terms of clinical applicability in emergency raw image data; 1.5 mm slices were reconstructed addition-
situations and accuracy of the final diagnosis [14, 17, 18]. ally by medical-technical assistants.
In our study, we retrospectively evaluated if 1.5 mm axial The reconstruction time of all picture data was manually
images provide diagnostic advantage over 5 mm images in measured with a stopwatch and noted for each patient in
the detection of thoracoabdominal injury regarding differ- standard and experimental slice thickness for all window
ent window settings (lung, soft tissue, and bone). In addi- settings.
tion, incidental findings and small osseous incidents were
examined.
Objective image analysis

Materials and methods All quantitative measurements were performed on a com-


mercially available PACS workstation (Centricity 4.2, GE
Patient population Healthcare, Dornstadt, Germany) using a standard cross-
sectional imaging reading monitor (RadiForce RX240, Eizo,
The study was approved by the ethic committee of our hos- Ishikawa, Japan) by placing regions of interest (ROI). Back-
pital and the data were retrospectively acquired. 167 patients ground noise (BN) was defined as the standard deviation of
(45 F/122 M) with an average age of 49.9 (28.8–71) years, attenuation measured in the air outside the thorax on the
which had undergone clinically indicated thoracoabdominal level of the carina (BNchest) and outside the abdomen on
trauma CT between November 2014 and December 2015 the level of the celiac trunk (BNabd) with sufficient distance
were included in the analysis. Patients younger than 18 years to the body to avoid distorted values due to blankets or bear-
or without complete CT data were excluded. ing devices close to the patient. Attenuation was measured
in the following anatomic structures: in the thoracic aorta
CT protocol and reconstruction parameters (ROIaortaTH), the abdominal aorta (ROIaortaABD), in the
liver parenchyma (ROIliver) and the portal vein (ROIpvein),
CT scans were implemented on a 64-slice sliding gantry in the spleen (ROIspleen), in the kidney including cortex
CT (Somatom Definition AS 64, Siemens) as monophasic and parenchyma (ROIkidney), and in the pancreas (ROIpan-
contrast-enhanced thoracoabdominal CT [20] with arms ele- creas). The signal-to-noise ratio (SNR), which measures the
vated above the head to avoid artifacts and additional radia- technical quality of a signal in the chest, was calculated in
tion exposure. 100 ml of contrast material (Xenetix 350, the thoracic aorta (SNRaortaTH = ROIaortaTH/BNchest).
Guerbet, Sulzbach, Germany) followed by a 50 ml NaCl The SNR in the abdomen was calculated, e.g., in the liver
chaser bolus were injected at a flow rate of 2 ml/s. The scan (SNRliver = ROIliver/BNabd); SNR for other organs were
delay was 80 s after the start of injection. The length of the calculated accordingly [21].
scan extended from the seventh cervical spine to the sym- The scan lengths (SL) between experimental and standard
physis. Reconstruction kernels were chosen as follows: B60f slice thicknesses were calculated by the quotient of the dose-
for lung, B30f for soft tissue, and B70f for bone window. length product (DLP) and the computed tomography dose
5 mm slice axial images were reconstructed for soft tissue index (CTDI) and were later compared (SL = DLP/CTDI).

Table 1  Reconstruction Window Standard reconstruction parameters Thin-slice reconstruction parameters


parameters
B60f (lung) Transverse: 5 mm/5 mm Transverse: 1.5 mm/0.7 mm
B30f (soft tissue) Transverse 5 mm/5 mm Transverse 1.5 mm/0.7 mm
Coronal: 3 mm/2 mm Coronal: 3 mm/2 mm
B70f (spine) Transverse: 3 mm/1 mm Transverse: 1.5 mm/0.7 mm
Coronal: 2 mm/2 mm Coronal: 2 mm/2 mm
Sagittal: 2 mm/2 mm Sagittal: 2 mm/2 mm

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Comparison of thick- and thin-slice images in thoracoabdominal trauma CT: a retrospective… 189

Subjective image analysis the beginning of the evaluation process of each set of patient
picture data, in different organ areas and slice thicknesses,
The subjective analysis was performed by two independent the rater gave a starting signal to the timekeeper who started
raters (radiologists) with 5 and 3 years of experience, respec- the stopwatch. The watch was stopped as soon as the rater
tively. The raters evaluated each image stack from both, signaled his completion of the evaluation (Fig. 1).
standard and experimental slice thickness, in a randomized
order, and had no contact with each other during the assess- Statistical analysis
ment of picture data. Between the first and the second read-
ing of matching CT images in 5 mm and 1.5 mm both raters Statistical analysis was carried out with the aid of BiAS soft-
underwent a 30- to 60-day interval to minimize recognition ware (BiAS 11.02 for Windows, Epsilon Verlag, Frankfurt,
effects. The two raters were blinded against personal patient Germany). Interrater analysis of trauma incidents was car-
data and the diagnosis of the first CT scan before recon- ried out using Cohen’s weighted kappa to show agreement
struction, so that neither rater knew trauma consequences of between the two raters during examination (k > 0.81 excel-
probands before the study began. Blinding against the slice lent agreement, k = 0.61–0.8 good agreement, k = 0.41–0.6
thickness of the rated picture data was not possible due to a moderate agreement, k = 0.21–0.4 fair agreement, and
much higher image volume in the thinner layers. Evaluation k < 0.20 poor agreement). McNemar’s test was additionally
time was manually recorded and the comparison results of used for interrater event verification with Zimmermann’s
predetermined organ systems were analyzed. The rating pro- effect strength ω2 (ω2 = 0.01 low, ω2 = 0.1 moderate, and
tocol (Table 2) with predefined pathologies was developed, ω2 = 0.25 great effect strength) and Chinn’s f/Cohen’s d
so that both raters could assess the same organ areas for a effect strength (Chinn/Cohen: d = 0.2 low, d = 0.5 moder-
comparable evaluation outcome. ate, and d = 0.8 great effect).
The raters reviewed CT data on axial images in lung, soft Wilcoxon matched-pairs test with Hodges–Lehmann
tissue, and bone window, and identified organ traumata of Assessor calculated the average evaluation time difference
different body regions (Table 2). The dichotomous decision between 1.5 mm CT data and 5 mm, respectively, 3 mm (in
whether trauma consequences are present in named areas bone window) for the analysis of interrater time variations. p
was noted. They could adjust brightness settings to their value under 0.05 was considered as a statistically significant
preferred range. The radiological report was treated as the difference in all the tests.
gold standard regarding all the findings.

Time analysis Results

The assessment time of each rater was manually measured Objective image data quality (compared using SNR) was
and noted throughout the evaluation of lung, soft tissue, and significantly lower in 1.5 mm images compared to stand-
bone window in thick and thin slices of every proband. At ard 5 mm images (p < 0.001). The average SNR was 8.64

Table 2  Rating protocol Lung window Soft-tissue window Bone window

Pneumothorax Mediastinal bleeding Rib fracture


Lung parenchyma injuries Pericardial effusion Clavicular fracture
Free air Liver Spine fracture
Soft-tissue emphysema Gallbladder Sternal fracture
Incidental findings Pleural effusion Pelvic fracture
Pancreas Sternoclavicular joint
Spleen Hip joint
Stomach Incidental findings
Small intestine
Colon
Bleeding of unknown origin
Free liquid
Aortic trauma
Soft-tissue hematoma
Incidental findings

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190 L. Guchlerner et al.

(8.61–8.67) in 1.5 mm and 12.73 (12.68–12.78) in 5 mm


images. In addition, there was no significant difference in
the scan lengths (p > 0.05).
The average reconstruction time of 1.5 mm images was
significantly longer than the one of 5 mm images with 33.1 s
(27.7 s–38.5 s) for 1.5 mm images and 10.3 s (9.2 s–11.4 s)
for 5 mm images (p < 0.001). The average number of images
per data set was 981.9 (878.1–1085.7) for 1.5 mm images
and 137.8 (123.7–151.9) for 5 mm images (p < 0.001).
Regarding the 3 mm images, the reconstruction time was
17.1 s (15.3 s–18.9 s) with an average number of images per
data set of 228.6 (204.3–252.9) (p < 0.001) (Table 3).
Analysis showed that both raters took significantly
more time evaluating 1.5 mm images than 5 mm images
(p < 0.001). The average evaluation time for 1.5 mm
images was 214.2 s (174.9 s–253.5 s) for rater 1 and 240 s
(196.1 s–283.9 s) for rater 2 (p < 0.001), while it was
148.2 s (115.4 s–181 s) for 5 mm (respectively 3 mm in
bone window) for rater 1 and 153 s (118.2 s–187.8 s) for
rater 2 (p < 0.001). Rater 1 took an average of 656.1 s
(655.9 s–656.3 s) of per patient in experimental 1.5 mm
images and an average of 450 s (449.8 s–450.2 s) in stand-
ard 5 mm (and 3 mm) images (p < 0.001). Rater 2 took an
average of 723.1 s (722.9 s–723.3 s) of evaluation time per
Fig. 1  Example images of a 23-year-old male patient who received a patient in 1.5 mm and an average of 459.8 s (459.6 s–460 s)
WBCT after being involved in a bike accident. Experimental 1.5 mm in 5 mm (and 3 mm) images (p < 0.001).
(a) and standard 5 mm (b) image data show a small liver laceration In all evaluations of the rating protocol, rater 1 discovered
(arrows) which were identified by both raters in both evaluated slice
a total of 164 pathologies in the observed areas (Table 2) in
thicknesses. The images (a) and (b) provide comparable diagnostic
accuracy 5 mm for lung and soft tissue and in 3 mm for bone trauma,

Table 3  Image number and 1.5 mm 5 mm 3 mm


duration of different slice
thickness reconstructions Image number 980.9 (878.1–1085.7) 137.8 (123.7–151.9) 288.6 (204.3–252.9)
Reconstruction time 33.1 s (27.7 s–38.5 s) 10.3 s (9.2 s–11.4 s) 17.1 s (15.3 s–18.9 s)

Table 4  Number of pathologies found in the study population


Thorax Gold standard Soft tissue Gold standard Bone Gold standard

Pneumothorax 21 Liver 5 Rib fracture 22


Lung parenchyma injuries 19 Gallbladder 0 Clavicular fracture 6
Free air 5 Pancreas 0 Spine fracture 11
Soft-tissue emphysema 22 Spleen 1 Sternal fracture 3
Incidental findings 1 Stomach 0 Pelvic fracture 6
Pleural effusion 6 Small intestine 0 Sternoclavicular joint 0
Mediastinal bleeding 1 Colon 0 Hip joint 2
Pericardial effusion 0 Kidney 2 Incidental findings 0
Free liquid 10
Aortic trauma 2
Soft-tissue hematoma 12
Incidental findings 8
Total (165) 74 41 50

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Comparison of thick- and thin-slice images in thoracoabdominal trauma CT: a retrospective… 191

while rater 2 discovered a total of 161 pathologies. Table 4


shows the total number of pathologies found in the study
population. McNemar´s test for intra-observer distinction
revealed no significant variance (p > 0.05). Rater 1 and 2
had a 98.2% accordance in the interobserver comparison
detecting trauma sequelae. Investigation results differed only
in three incidental findings of lesions in kidney and liver
of different patients. These findings were confirmed by the
gold standard.
Rater 1 had a sensitivity of 99.4% and a specificity of
99.1%, while rater 2 had a sensitivity of 97.5% and a speci-
ficity of 98.5%. These high results can be explained by the
predefined evaluation areas in our rating protocol (Table 2).
In layer comparison (1.5 mm versus 5 mm/3 mm),
Cohen’s Kappa calculated average results of 0.98 (0.96–1) in
lung (p < 0.001), 0.83 (0.66–1) in soft tissue (p < 0.001), and
0.89 (0.78–1) in bone (p < 0.001) analysis for rater 1. Rater 2
had similar average results: 0.93 (0.86–1) in lung (p < 0.001),
0.85 (0.69–1) in soft tissue (p < 0.001), and 0.9 (0.8–1) in
bone analysis (p < 0.001). The null hypothesis, that there is
no difference between standard and experimental evaluation
method, can be adopted. The additional appraisal in sagit-
tal planes during bone window analysis showed two hidden
fractures of transverse processes of vertebrae.
Fig. 2  Example images of a 24-year-old male patient who underwent
a WBCT after a fall from about 4 m. The arrows indicate a small ven-
tral pneumothorax which was equally discovered by both raters in
Discussion experimental 1.5 mm (a) and standard 5 mm (b) slice thicknesses

Whole-body computed tomography (WBCT) has a well-


established role in trauma diagnostic due to high accuracy Similar results were reported in Abdelmoumene et al.’s
and fast detection time [5, 7, 8, 22]. Higher image quality study in 2005, where 5 mm reconstructed slice thick-
and thinner CT layers demand a longer reconstruction time ness with elementary collimation of 5 and 3.75 mm was
and higher capacities of data storage space [23]. Thin-sliced compared with 2.5 mm reconstructed slice thickness with
computed image material is often used for the identification 2.5 mm elementary collimation in the diagnosis of liver
of fractures and expanding lesions [14, 16, 17, 19]. To our metastases. The results showed that 5 mm slice thickness
knowledge, the benefit of thin-sliced CT data on thoracoab- proved to be more effective in the detection of small liver
dominal organs in trauma diagnostics, however, has not been metastases, again because of higher noise in 2.5 mm slices
demonstrated or observed yet. The results of the comparison [25].
of 5 mm and 1.5 mm slice axial images in our study show no Both studies explored different slice thicknesses on CT
additional benefit from the utilization of thinner slice images for staging purposes, which differs from our investigation in
in thoracoabdominal trauma CT (Figs. 2, 3). trauma diagnostic. However, each of them still manages to
In 2010, Soo et al. investigated the advantages and dis- show, just like our results, that thinner slices do not always
advantages of 2.5, 5, 7.5, and 10 mm reconstructions of CT imply higher likelihood of finding hidden lesions.
images on the detection of liver lesions. Their study reported In our study, however, we managed to detect nine cases,
significantly improved sensitivity in 2.5 and 5 mm (92% in in which fractures were found in 1.5 mm transverse bone
2.5 mm and 98% in 5 mm) as compared with 7.5 mm (78% window evaluation and following sagittal appraisal, that
sensitivity) and 10 mm (54% sensitivity). In addition, they were not identified in their 3 mm correlate [13, 14]. Those
noticed an impaired diagnostic accuracy in 2.5 mm com- nine fractures consisted of three rib fractures and six frac-
puted slices compared to 5 mm (92% sensitivity in 2.5 mm tures of transverse process on cervical, thoracic, and lum-
versus 98% in 5 mm) due to lower SNR. The study con- bar spine on different patients. These rib and transverse
cludes that it is not just the thinnest CT slices which bring process fractures had no impact on the first-line treatment
the highest diagnostic accuracy, but the balance of slice that the patients received, because they were not life rel-
thickness and background noise [24]. evant at that moment, but they still could give an indirect

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Fig. 3  Example images of a 38-year-old male patient who received


a WBCT after he had fallen down the stairs. In both, experimental Fig. 4  Example images of a 47-year-old male patient who underwent
1.5 mm (a) and 5 mm (b) slice thicknesses, the raters identified a ven- a WBCT after being involved in a car accident. The arrows indicate
tral discreet lung contusion (arrows) a small ventral pneumothorax and the stars are located next to a rib
fracture. The raters concordantly identified both trauma sequelae in
experimental 1.5 mm (a) and standard 5 mm (b) slice thicknesses

indication for underlying hidden organ trauma [26]. Thus,


the usage of 1.5 mm can be helpful to detect hidden frac- findings were: one kidney cyst of small diameter, one liver
tures with potential clinical relevance. The identification hemangioma, and a small lipoma (Figs. 4, 5).
of every rib and spine injury could improve the patients’ Objective image analysis showed that thinner CT slices
rehabilitation time by facilitating a proper treatment [27]. impair picture quality and reduce evaluation accuracy
When it comes to unstable hidden spine fractures, the through higher background noise [31]. Moreover, thinner
additional information theoretically provided about them, slices of 1.5 mm cause a higher picture count, which results
could allow a better first-line treatment, and, consequently, in a higher processing length during conversion from raw
improve the patients´ outcome directly [28–30]. However, data to reconstructed CT data. They also demand a higher
during our appraisal, there were no further hidden frac- evaluation time. These disadvantages lead to an extended
tures of vertebra bodies detected in 1.5 mm, which had diagnostic duration for trauma patients during emergency
not already been identified in correspondent 3 mm slices. situations, which could affect a patient´s prognosis and
A supplementary inspection in sagittal layers showed a health negatively [32].
clearer view on the rib and two hidden spine fractures Our study has limitations that need to be acknowledged
in the present cases. Whether sagittal CT layers could beyond the retrospective design. Raters could not be blinded
find hidden fractures more effectively, should be further against the layer thickness which they were evaluating,
investigated in additional studies. Besides, three inciden- because thinner slices result in much greater picture count.
tal findings, which were not clinically relevant during the The raters were, therefore, aware which CT slices they were
emergency of polytrauma, were found in 1.5 mm but not analyzing and whether the pictures had been reconstructed
in 5 mm soft-tissue evaluation. These incidental findings, in a standard or experimental way. Some patients showed
however, deserve proper investigation after the sufficient a low share of trauma consequences. This circumstance is
treatment of the trauma sequelae. The three discovered explicable, since indication for polytrauma diagnostic is

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Comparison of thick- and thin-slice images in thoracoabdominal trauma CT: a retrospective… 193

Fig. 6  Example images of a 54-year-old male patient who under-


went a WBCT after getting trapped at a building site. In experimental
Fig. 5  Example images of a 48-year-old male patient who received a 1.5 mm (a) and standard 3 mm (b) image data, the stars are located
WBCT after a scooter accident. Experimental 1.5 mm (a) and stand- next to a quickly recognizable fracture of a rib body, while the arrows
ard 3 mm (b) image data enabled both raters to identify the shown rib indicate a smaller rib head fracture. The raters equally identified both
fracture (arrows) shown fractures in 1.5 mm (a) and 3 mm (b) slice thicknesses despite
the risk of overlooking the small fracture (arrows) owing to the satis-
faction of search phenomenon
enclosing and justified through injury mechanism. The study
was carried out with a 64-slice CT scanner. Image quality
and evaluation time differ on devices with other (especially
lower) technical specifications. This can affect the generaliz-
ability of our study [13, 33]. of search phenomenon, in which an observer might miss
The prevalence effect may also influence the transferabil- a radiologic diagnosis due to the interference of another
ity of our results: This study took place in one of Frankfurt´s finding. Despite this precaution, the satisfaction of search
largest trauma centers with a high prevalence of patients phenomenon might have influenced the detection of small,
with severe polytrauma. Therefore, many patients had mul- but relevant bone fractures, which could finally be shown
tiple major injuries, which could increase evaluation suc- in 1.5 mm experimental layers and in sagittal view (Fig. 6
cess. Other centers with lower numbers of polytraumatized shows simultaneously occurring small rib fractures in
patients might encounter a decreased amount of trauma con- which the satisfaction of search phenomenon may arise)
sequences and, thus, a shorter appraisal time and a smaller [13, 35, 36].
diagnostic accuracy. Gur et al., however, showed in their In conclusion, there is no diagnostic advantage of
study that the prevalence effect in laboratory conditions is 1.5 mm over 5 mm in thoracoabdominal trauma CT
negligibly small [13, 34]. regarding lung and soft-tissue pathologies. The evalua-
We defined a rating protocol to standardize the evalua- tion of bone pathologies and small incidental findings,
tion of regions after trauma through the two raters in terms however, benefits from thinner computed images through
of assessment time and accuracy. In addition, this rating higher diagnostic accuracy (Fig. 7).
protocol had the objective of minimizing the satisfaction

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cervical spine with multidetector CT: 1-mm versus 3-mm axial
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speakers’ fees from Siemens Healthcare. The other authors declare that
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