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TmL/kg) J PRET, M2 GEESE SY FSF Ce) / CMe] * We 20 A PS EH, EG I BK, SCRE RHEL AR PAE AT RY CURES) UE SHR 4” hace AD ML) BIRR -4 FRG (M2) 3? — ARERR -4" /7-0- RRL AD (M3) 6” -O- ACBESE 4” /7-0- WEAR AD (WA) LEE 4? /7-O- BEARER OD (M5) BAR BITRE 4" /7-0- BRA AD (M6) 3? ~ FER EF 4? /7-0- TRE 9 (MT) Ka 7-O- fil SURYA SE Ay (8) AG BPG 4” )- ER AD (MO) HR HR -T-O- FH 4G BEY 1) 3A 3" — FRE 4" -0- HAT HE EP (2) BR 4? -0- Fi ET HF OG). BARR -3" - PAGE -4 UAT BEEP C4) LEP TE ~4” , 7-0- FAT RE AF (8) LUE IG -3’ - PERE 4” , 7-O- HESPREEF (13) 3” - FUSE -6" -0- ABH / SRBNSE BR (18) 3" ~ PASE ~6”-O- ACHE / FERRIER GF (36) AGRE ~3"~ AGE -4”, 7-0- fi APY (9)? — SEB IRR (6) GATE GD BARR IT AIE 1" -0- BEAPRETE (D 3” ~ FRIE -6” -0- ACHE SE BAR HE (10) 3” — FRSE - BRR TY CLD BARE (12), 3’ ~ FRUGE RL (14) 6” -O- AHESE RS ALR (15) BARTER (16) ATF (19). 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Sem, 3.0u m) 5 FEW 235 ABT A Qn BEAR HE BC Zo llie ) BA AE DEIR, THERE 0. 7hmL/min, DEEL 223 5 LBL ST UR EST) RFA TERS TBE SRF AY MRM HD 244 SSE A SP A A ba Me Rt LE UPLC-MS/MS £6,188 LEE 1-3. 5/9 fooss] e144 Et bR AY Je PR YNEY UPLO-MS/MS 22 BEG} HT MRM BBL _ mizot —mizof Dwell Cone Collision Funcion Mesuistion Components srcursor product time valage valage ime(min) (PeakNo.) ‘ion(Da) ion(Da) (s) (eV)_—(eV). 35-76 Mi 503.13 417.17 06 32 20 MB 431.04 255.08 04 30 18 2 66-87 M2 49712 29717 05 40 30 3 87921 41736 06 43 2 MS 49712 255.08 04 30 32 ©) 918 8 879.12 255.10 05 32 35 M6 629.04 497.12 06 46 2 (©) 94-118 —M10._——«415.02 255.08 04 37 25 (ooo 2) 118-127 9 60947 285.13 08 32 28 118-133 12 4171729710 05 38 25 14 44720 32715 04 38 26 (1271511516 849.17 «417.17 0540 2 18 579.15 447.20 06 40 2 (10) 14.0~15.6 19 41718 255.08 06 30 20 (it) 151-165 22 565.19 433.12 05 30 20 Mo 33509 255.07 05 32 20 24 417.11 25507 06 38 18 (2) eats 23 60693 29901 06 23 18 baicalin 447.12 27108 05 25 22 (13) 165-205 29.30 563.23 431.16 07 37 2 40 255.07 19920 06 37 2 eee a 956.04 95575 06 70 25 (18) 205-217 34 98554 985.80 06 70 25 (16) 217-238 30 82380 82367 05 70 15ON 104833748 4 wom Fs 6/9 KH at 969.96 96957 06 70 25 (17) 23.8-26.0 45 985.98 985.81 06 70 15 (18) 24.8-26.2 digoxin _—803.75__-803.70 05 60 15 49,51 793.89 79367 06 70 20 54 807.70 80789 05 70 20 (19) 25.8~28.0 53 969.96 96936 05 35 25 [0050] 52 1132.13 1131.93 04 70 25 46,48,50 1264.17 126417 04 60 30 (20) 27.5~28.7 55 1233.25 1233.25 04 70 25 (21) 28.0-29.0 56 1101.91 1101.91 06 70 25 (22) 28.5~31.5 58,59 969.96 969.27 07 70 25 (23) 31.0~35.0 60,61 807.70 807.97 0.7 65 25 (24) 34.0~36.0 64 789537895307 65 30 [0051] 3.3 Py SLL UPLC-MS/MS 4} (oos2] 3.3.1 WELD Coosa] AIG A 2014 A ANS aR A Se SE BS A RE 28 Jb (L BERET R31” eB ae RR EB / TN Aa AP RO Ha LY (S/N > 10) 1 44 MERRIE 4 KK Coosa] Be EF AY APART SEARS LA UME 12 HVARBE ) M2, M3\614,40 5 (loose) FRAY RVR SEARS G14 IME 19 (EF ) M1, M5, M6, M8. M9, MLO,3, 15.16.18, 22,8,9,24,23,29,30 + [0056] RA SAE A SATE LH WME 52 (A SALE Rb 1) 46,48 50,53,55.56 58, 5960.61 : [0057] RAS SAMA SALT GLH Wt 39 A SL FF Rel) 034,37 41 45,49 64. (005s) AMR. AGH. ASME Rb, MAS CHE Re, (HAMS. (ooss] 3.3. 2 Py Se be My bash ve ipeiie tl [0060] HAMA SEM SMR. AGH. ASE Rb, WAS BH Re, HAG, HRS SRA Ea 1 Oana /mL, EPD aS ie 2 A SLE a DLA FL PE — 7 (12) 5B SAE RR UME CARR 0. 4 ~ 120» g/mL, AG AF 0. 01 ~ 30 g/mL, AS LEE Rb,0. 03 ~ 90H g/mL FA B58 $F Re,0. 02 ~ 601 g/mL) 6 [0061] 3.3.3 Py SLL y QC seme ll a Cooe2] aes RL te baits fe OL RL PAL SP — oe (124) A a RS AL SEW OC HAP. Coos] 3.3.4 WEA QC FAFspeIH i a Coes] if HALE 240 7 Hee HO ak AE DA A FE FE (2. Omg/mL, FB WE Ak Ch 1) ) Je FPR ~ 7K (124) HER RIAA QC (m-QC) HABE (006s) 3.3. 5 Py bier spel hil 966) FREAK EY (SL ESA APM eA Bae) Ae CAS EPR WPS aD ) Ae SR Sa AL FP i CHR Ay. 20ma/ mL. BAI AY Ba AaB. A RS EE A ith UE FEL ORE HA PERE, CRF EE 40 v g/mL SRE 25.» g/mL) 8 54,ON 104833748 4 wom Fs 9H (oo67] 3.3.5 ME MRI 45 nea FPL Loose) A ML Fe 4 Py SH Mi He IRE Ag BR bas x) 5 Py SS Ee aS pa we TB LE A i Cy) FELIMAR Se] EAA RE AT IE YL, RA A/S A MAR] VAT FR ARAL Cr) ESTAS EE FBR (LLOQ) MLE 2. (ooss] 2.4 PAN SCN HET Set FP [0070] = . eet gare Ase eRe MRR (vgimL) (ugmL) BRK y= 0.0974 x + 0.000288 0.9909 -0.0075~22.5 0.0075 ae y= 0.2212 x + 0.000031 0.9966 0.0020~6.0 0.0020 ASS Rar y= 0.1284 x + 0.000023 0.9978 —-0,0040~12.0 0.0040 ASF Rb, y= 0.0966 x + 0.000029 0.9948 —-0.0060~18.0 0.0060 (0071) 3.3.6 Ria e SME ai ne Coor2) HR AR AF IM A Ps SLD QC HARDER HE, itil OC3.( iE) AC2CF) ACL CAE) SA RACE NY QC PEt GEAR IE 5 PEAS, RESROMIT 3K, HE HR, HLA OC REAP Ds SB Lei FIL WEES AREA TEE A STE Rb, ALA STF Re, WME SAT BNL. SERGE CFDA IF MOREE PATTER 0 Coors] ie 2 Fi tL AR. 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BTA M5 164x107 900525 2k 7G 115 tt 8 60 14 983 375 S22 BSBA 8.01 Mé 811556 4818s 808 8B Sd M10 10310? 940479528 308507300282 Se Ne eee) ea Ne ND NY 12 rasx10? oro isto? 716 6324080705 14 2eseo? sant" see 0123.80. 15 3350182 BA BT BS THE 8B 18 ez =a 0st DA 1878 «= 38318788 BAB OT nd nd 1? me tr sm Re | (toa 77k 8D SAR 2200 83008814 ND ND OND ND ND OND we 4400 MEA kn 240 554114828 ND ND ND ND ND OND 230479182828 ND ND ND OND 28 dont am ND ND OND 300 287106 4718911258384} Ce Ry eect CN Se ee 377710" orto” 45728812 HTT ote 00 Slee eat OND, ND ND OND 39 So2x10° 229x10" 765-200 2.5 OZ 353 BBG Pe tye ey a) ee ae 45 ars 3ST 50k 2 ND ND ND ND OND 51 937 7S 2S 18240 103 848788 a a a a a 53308 SIT, 283022868 asT 2802S 52 724x10" 70rx10" B.43~10" BEtA10' S6Ox10' S.75K10" Sosxt0" STax10" S.26e10" 46 136810" 1.28«10" 1.17610" 415x107 1.2810? 409K10? Losx10? — a98 27 48 3.44810" 296x107 2.37*107 22510" 254x107 204107 22710" f.97x10? 1.75810" 50 1.4810" 1.46x10" 1.92610" 1.32010? 1.3810 1.18810" 1.19x10° 108x107 1.02*10" 55 sme saz gy att Soy ast dst do) 56 316x10" 269x10% 2s8K10" 22710? 2.52107 2ogx10" 240x10° 4.9110? 1.7e<10" [0082] 10ON 104833748 4 wom Fs 9/9 HL 5B 1.36x10" 1.2810" 1.26x10' 1.13610" 1.2810" 1.06%10° 1.10%10" 1.02*10* 9.8610" 5Q 241x410 1.69x10? 1.67%10° 1.36x10° 1.0910" 994 775, 569 550 are 160 144 6 48 et BaDA 61484 238 178 146 00=CTS MS BOS BA 64276 74877838490 ND NO No [0083] 4.3 BAS EARL A GREK AE IE Cooea] HF ES AIMS TE) 2h 44 AM RR SP ARE BAC ID is “RE Sy A HAC PE — LT) HR LPS 4 (o0gs] 4. 4. 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