SEs oes > EO) Ea Oe) ‘A s2.yeacald woman cames othe emergency deparert uso ecwrer ght owereeremy Swing pan, and enghema. The tens rmeacalnsiry naudes ype? dates Melis and depression Her meacalen indice mem, pacacne, and arussanun. The patent 'slagnosee we celui, aritadtothehospal, nd stared on artes. Shale comued on her heme mecratns. Thee da ete ne ‘ate becomes anated nd cebious wih severe absominal carps andrea. Herpes 33.2. (1026F), Hod pessires ‘21100 tiga eat in 120rin are rr. Ch exarint, he pers daphortic weeds aes pup re ined lateral nypereea ar aie conus ae Nese. She begesiohavesazires Wich othe olwg antics was Me pat mas ey vento wate calis?ere Gand ‘A oyea-ald woman cames othe ofc a 1 crvenle at and tron. Te pater sys She woes cnsardy aout mune ses lnvtg her work ances, ard amy, A wor, shenas aly concerning as herpes cats chek fe whereabouts a saety ‘ofhorhustard and chiren. Te patent also doserbes euorersionheacaches, ack pan ard fabqe. She des noel pressed and ‘sastather Seen are appete are neal Laborer sues, ncn yr ncson ess are wih perma rts. adaion oa ‘recommendation of eyhoteapy,phamacoheapy wih busaronesnited. Th mec emanated wth hich the elloing rmseee peri: fica ingaie derder iphone fects Muse rena popes Nene cependence ap onset acten|6 a] GB ae ‘A s2.yeacald woman cames othe emergency deparert uso ecwrer ght owereeremy Swing pan, and enghema. The tens rmeacalnsiry naudes ype? dates Melis and depression Her meacalen indice mem, pacacne, and arussanun. The patent 'slagnosee we celui, aritadtothehospal, nd stared on artes. Shale comued on her heme mecratns. Thee da ete ne ‘ate becomes anated nd cebious wih severe absominal carps andrea. Herpes 33.2. (1026F), Hod pessires ‘21100 tiga eat in 120rin are rr. Ch exarint, he pers daphortic weeds aes pup re ined lateral nypereea ar aie conus ae Nese. She begesiohavesazires Wich othe olwg antics was Me pat mas ey vento wate calis? A. Cindamyen (16%) 5B. Donoysn (2%) ©. raze 50%) e Penicen 5) Vance (108)6 a] GB ae ‘A s2.yeacald woman cames othe emergency deparert uso ecwrer ght owereeremy Swing pan, and enghema. The tens rmeacalnsiry naudes ype? dates Melis and depression Her meacalen indice mem, pacacne, and arussanun. The patent 'slagnosee we celui, aritadtothehospal, nd stared on artes. Shale comued on her heme mecratns. Thee da ete ne ‘ate becomes anated nd cebious wih severe absominal carps andrea. Herpes 33.2. (1026F), Hod pessires ‘21100 tiga eat in 120rin are rr. Ch exarint, he pers daphortic weeds aes pup re ined lateral nypereea ar aie conus ae Nese. She begesiohavesazires Wich othe olwg antics was Me pat mas ey vento wate calis? A. Cindamyen (16%) 5B. Donoysn (2%) ©. raze 50%) e Penicen 5) Vance (108)a] GB ae + Sertnerge meccatos, 6 a] GB ‘A ae-yearals woman lh ep pclems comes tthe ofce Orth as year, she has had weeasing ey aig adept andi cemnasstes aurng te day Te patent des reuse ae, acca alas. Shehas family sly athe dsease ard depression “The patennas fied a number oferpramarolycal approaches, ncing cogntie-ehavralheapy insomnia. Shorequeets ‘ptarmaclogc teatment ads pescibed ashe course of zondem. Wich ote flown th mos ety mechanism of cn of is ‘A. Dopamine ecantoratagoriem (1) 1. GABA recep agen (4) (©. Hstamne repo antago 1%) 1. Mettonn recetr apni (34) Cri ecpirantagonn ) ‘Satonin receptor ageism 2%) Zalpide is shot acingnenbenzedasepinehyprac agent Ohermedstors in is cass ud 2pon and eszopone Like ‘berzelazepins, tose mesons bro the GABA. recap atthe brzodazsoe recep to, wher they 312s GABA ago. Howe her eerily int entered od nase secre ae, A 3a] GB Zelpdem ss eho acing nonbensodanepine nyse spat Oherredestons ne cae sise aiplonansessopene Like berenazepines, hese meieations Bnd the GABA, recepr atthe bezndazzore ce ste wher hey 213s GABAA ago However the are cemcaly ds! tom beeadacepnes, nth tning mere spec ar cea recep sypes. Asa rel, nonbanzedazepins af pinay hypnees ado not rode ean usc ena, cr artoovdsart as asst wh berzodazepnes. Nereenzoaarepnes cause sivas eso beaadanapnes ep, nOX-ay Sameclnce cegute dystuneson Weseasad kot asa er ‘us, They tel ne sed foe shortest te posse and ate lowest eecve dos (Ghote A) Depa reento artagmism the mechan of conf iseyhoc meccaton o, alpel seen) (hole) Hiterine receptor angen the machen atacsn of nthstmnes (an. phenhystamine)Amough arenes sre fen eds rertiecouner Sepa, ere sil evidence forbeneft in nso (hetee D) Melton epic aan he mechan of acten fhe sonia medcaton anon, (reiee ) Orn ceptor aagonsm te mechanism ata he senna meetin sino (Ghote F) Sertonn recep agsismisthe mechanism of acon of titans used reat mira headaches and of paced, allot LSD} Education objective: Nereereazepne mediators, zdpiem, zlepon, eszopione) stu spec sutnpes of GABA, recon. ASE eae ae eae relearn erwodazeones, References Randomised lic isl be fects of prolnged esse melt, emazepem and 2pen an ow wave ath ung sas inEO) CL Co 48,yeald woman wt corson an fevers ought Me emsigeny depatnen, Shes doe, sete, an ct trois. A ‘nerd who accomeants he pater say, "She sounedreay cus when! kaso het ane anes deed a checkin oN. She was pstong onthe coun ard ganing when get ere. | ope she dt cerdoseagan—sh's edo bts" On physical xamnate, he ates skins shes cel mucosais ya puis are cates and per response light. hich oheellwing as an in (redone, oid me ey cae fi inca rece?6 a] Ca 48,yeald woman wt corson an fevers ought Me emsigeny depatnen, Shes doe, sete, an ct trois. A ‘nerd who accomeants he pater say, "She sounedreay cus when! kaso het ane anes deed a checkin oN. She was pstong onthe coun ard ganing when get ere. | ope she dt cerdoseagan—sh's edo bts" On physical xamnate, he ates skins shes cel mucosais ya puis are cates and per response light. hich oheellwing as an in (redone, oid me ey cae fi inca rece? A Amarin 60%) 8. Dazepam (10%) ©. Haopril . Prazosin (8) Prpranl (16)‘Antchoirergle oily = = sesatew —————— |r asa | Gander secretion & smooth muscle contraction (eee [aetonateer 2 mate [apes emai bay ot 1 |oend as bat Pax of ciliary muscle & iis sphincter _ [Orciopiega, mycrass a a = faceeseace ee 2 freteesaeee een = Soy] wan tesaon ‘intestinal smooth muscle contraction | Constipation . F (gsc “This pater xis sans nd eynpioms of andchoinerle toi, which ess rom the iin of choiergerewetarsmssion at muscarinic recepors. Classic maniesatonsincde fever. delrum,micosa avi dryness, caren Fushing, oreacive myéasls ansuinayrtaon,Tasycatia and doscased de! sues ae et canon sens ‘Articroineritovt is assaf wih rumeros ove-he-ouneeg.arhetanipes, seep as cll ereparonsandeescreten ‘rescatene “Weyle anidepresant (CAs) we sramony iret party ane it tng artcinerg roars such a2pedo a ee musenine recep, Cast maniesstonsincde fever, delim mczal army drness,canecus Bushing, orreacive mydase 2rsurnaryrtanion,Taaycatd ad deceased vel sounds ae cet cannon sons ‘richie tovity is assoate wih rumeros oe he coun eg arhitarines, sep scl repairs) and peescrton ‘mascatens:"Weyele andaepressnts (TCAs) te srw rea parca anes ih sing arecotneryc operas Such a5 ‘mtpiyine. When akan n excess TAs can aso nase GS dation cae ety, and precip sees, (hcion B) Typical srl of erasers vas ine sedan rere ares, ned repr depression (helen €) Halopenele a hgh ptncy, fst goreratonatpsychotc (SA) tet manly causes rewnlepes side ts det peter 2 artagenism, artchtnerg eects are ere commen with v-ptecy FAS en cHopromazre) 3 (choiee 0) Pasin isan abe aerric ekrued io eathypeiensn andr ttn de benign pos ype, ta a map averse lots hypotension (especialy postal hyctanson = (rote ) Aare tess associated wih an ovecnse of anonsclemve bela arene loker include Wenchacnseton,yptenson ard rs Drsjennthms (Choe F) An oertose os sts session pie hg, Satna) mars sertnn snare whichis harctarzd oy a aptated dleum,asonorcintabiy secures, myedonus,hyparefea, and daphoreis a anid a in archolnerge verdes) z= Eduestons objective: ‘Arocraoergic net charactezed by ever cons, anes using yea muse rd le pony este sus. Tyce artdopessanspaiulaty amine, have sug antchelnarge eft Phamacougy sychamelBehavol 4 Stesarce Abuse AtehnergesSea ee > EO) Ea Oe) -A2t-yeold mans tandunconsus in ebsoanent of ie haus. His nichercll emergency tespendrs nino at eat as istry of substance abuse end was recenyhosptalzed fo mar depressive ode. nthe enegency deparmen, ne pant found tobe cyaatiand uresponsive to parfl simul Terperaie is 95 7 C (8.1) los press 1152 men Hg pulse Sn, and respratens are mn. He cus are conscted and mnimalyrespensite eight. Resuscizon eft re nites. The patentee ‘nkovensus medeston and regan coneccistess mantener The dg ely used eat the patenthacthe eta tint fr nen ote blowing reaps? A our 8 ota) aioe De ee -A2t-yeold mans tandunconsus in ebsoanent of ie haus. His nichercll emergency tespendrs nino at eat as istry of substance abuse end was recenyhosptalzed fo mar depressive ode. nthe enegency deparmen, ne pant found tobe cyaatiand uresponsive to parfl simul Terperaie is 95 7 C (8.1) los press 1152 men Hg pulse Sn, and respratens are mn. He cus are conscted and mnimalyrespensite eight. Resuscizon eft re nites. The patentee ‘nkovensus medeston and regan coneccistess mantener The dg ely used eat the patenthacthe eta tint fr nen ote blowing reaps? A SHT O%) 5. Data (0%) © capaauny cans e%) appa (1) < su ee) 6. MwA) “This paserts histo ofsusance abuse, miosis, profound sedation, anc espatry depression Wi aid eves of sprslsyrpons wtha] GB aioe a ee “Tis patenes hist ctsbstarce aise, esi, profound sedation, and espatry depression iP rai evel fasta wih amici terpyscnster wih n opleld overdose. Saver op recep supe, incting mu, ta and apps, Rave been er ‘valle paid medcatons (9, rahe, hycromorhone rode herapebeaalgest eects by binge hese recep ae mosiaing an perception Nalorone ic 3 ue oplld receptor antagonist evi of ay agp properties. Atrough trtaperies ois eect at al eCaT Nps has the erestes any for mu receptor (esponsble f pisnduedcaneresiatony depression). Naloxone competes wih ofc rmascatens aspaceg mem Yom eo ees £sMsele an aget reversing alld intxiestieverdoes, Revel efests can eco winn mates, ane ato dose depndet (sua 1. Rows). Nacrone must be en prey because metabolealy inactivated by th vr when acinsred oly (reie A) Mesteanon wn an tnt fT sect) eee ort rave 2roln he veament of pd oerse.Cypehepatn, 2 [SHTIA and SHTZA antago ean ral medcaten at can be wee eel srotonn syne Cranston is SHTS angus at may be admnisteredinravenusy fr nasea ane von (rotes 8 and E) Det ahaa are aso op cess hat modus pan. Aougnralowne does to hese ect, an oma ped eer wi rates atity. (Croies Cand 0) GABAs me pinay nnbcay neworansntar ne ta andi the gel et mary dugs. Serzodanepnes ans ‘anaes wonky bndng to spc tes on GABA A eps nace bry feds c GABA. Fnazents a GABAA ‘berzhazepine receptor antagonist vedo reverse brzndazepne mpiaton. aclien isan agent at he GABA B receptor hat 2s 36a ‘alta muscle rearart. Ths patent's mises ad profound respon derressan are mere nave of opi evens han brzodaopio or ockter nosaton (Chole 6) Gizanaeis messin neurranemitertnt ngs to NMDA recaps Katarne general ans, an expat an WA eepto aragonist Nalexone does ot have eect cn NMDA recep Educational objective: Naloxone is a ur epi receptor rtagoit vedo eat ci rtoncaten reverse. Atreugh tbs om, appa are dt epic receptors thastheaetest aft fo mu recep whch reste oc nde rape and respon depression mating tieoo a 2 Pe gren poe nace by he Wer when arnseed aly {hoie A) Meciabon wth an aint for HT aston ecelrs rathave sin the tesient of ped averze.Oypchepaing, [SHTYA and SHTa8 antagonist ean ral medcaton fat can be eee el sain eye. Crdanaton a SHTS aniagont hat may beaded nr evens for nasea and vom (hoies Band) Data at tappa ate aso op ces hat modulate pan.Aihaughralowne ees hese rece, ins toms ed ceptor win estes ty, (Ghojes € and D) GABA he pia inhibin neurone ne rain andi the get of mary duns. Benzodiazepines and arnraes work bingo spec tes on GABA A teepis a ace nr feds of GABA Flanazent's GABA erzodazepne receptor aagonst vedo eversebazadaepnemibuston aces an agznst the GABA Brecepor tat 2 35a ‘alts muscle retarart. Thi patent's mises ad profound respratoy depressen are more ncave of pad evertose han barzadazopine or secbfernoweaton (hele 0) Stuanateis an excitatory seuransmite that bade NUDA recep. Kelanine gone anesthe an example can NNO recep nage. Naloxone does ot have eet en NMDA recep. Edueaona cbective: Naloxone is a pur paid receptor raga vedo teat oiirtoncaten reverse. Atmought nso mu, kappa ard dt pod receptors thasthe gett aft fom recep whch rite fc snducea racy ar respi egession making fa ie 292 or eating op norcaton References Pramacsbay Paychatie/Behavorl Stesarce Abuse Onises a a) Cr OO) ‘.3-yearald mans osplzed ater susan mute ues dug 2a veniecllson The patel a census nly anno noma i avatneepacg ns meds stoy, Two aaj ater nil hspazaton he exgereres paps and aft sleeping ‘Sony erates he patent stars agenesized tonic clone secure When nerecnvers, etal te physcan tht vate | rmescatons amie, Dosa dscréer, and coc im bakeain, Temperature 287 C81), bed presses 12382, puss aime, andresratons re min He appears anecus temas, and dapat. heal omwhch the alow meseabera the moth explanation fr spats reser’?pane deat Shs 2) Re ‘.3-yearald mans osplzed ater susan mute ues dug 2a veniecllson The patel a census nly anno noma i avatneepacg ns meds stoy, Two aaj ater nil hspazaton he exgereres paps and aft sleeping ‘Sony erates he patent stars agenesized tonic clone secure When nerecnvers, etal te physcan tht vate | rmescatons amie, Dosa dscréer, and coc im bakeain, Temperature 287 C81), bed presses 12382, puss aime, andresratons re min He appears anecus temas, and dapat. heal omwhch the alow meseabera the moth explanation fr spats reser’? A Laromiane (1%) Lion) V6 Lomeapam 5) 1. ovjeedene 2%) uctapne (1%) Savane a) 6. Vabroat (4) ‘This paserts presertaon scarier vith benaodazepine withdrawal orazepam) which s most fen chracerizes by rebounda] GB aioe a ee “his patenes presertaton canister win benaodanepinewiarawa (9 lazepam) wich mst fen characte by rebound anxiety tremor, interna snc sympatthyperactity (69, aphorsis paptatons).n cer case, payhateaymptoms 0, Facto, detusens),seaures, anderen death may ocr, Rs of hrs reese sher-acing ager en, abrazcam), pronged ue, andre ol higher ores ‘enznsavepnes act onthe GABA. recep, enhancing the acon ofthe natural gar GABA, The bod adapts chronic banzadaepne ‘rors by dwmegling he GABA. recep, adn lerancea phenomena in whch th same dose ofa medication yes easing erect over ime. This sae adaptive anwrveguaten loess responsible evndaval yam when berzadazepns are ascoriies anne bays uate io balanceoppasig exci rewcansours. Beraadazepnewsnaval ls ese by stag 2 patent cn alone acting bereadazenin(e, diazepam) an pla oan ended gradual ape (hoies A and 6) Te anteonrsatstanarigne an vapcate ae used nol soe era mees sally poperies Waa ‘tom nese medcatons wound produce seaues a pallet wine an unde sae dcr eee eee ee eee anaenspet rebouns psyche syapions came resessess). Hower, arava om hese medians woul rt expan is stents ympims or seize (ree B) opi ep onesdon)wnsranals characterize by nausea, vomtg, dares, cation dated ppt, anpoetecon (GhoieeF) Select seston eupake inhibitor (9, sean) wihawal resents wth rebound aedschoa, zines Peadache, Edueatona objective: ‘Serzodazepnewitcraval is characerzedy ae, temo nsonra, ard sympathies hpeaciviy en, dlahores.pababens). Severe ‘secsiazepnethavalmay ase accompanies pajchoan, zezter a death References + Bereotacepine ham how cant be read? + Sessiuetypote ra harvey: ecgnton an resent'42,yarld woman wh 2 stay of snzoptvena ought the ene by het patent te atengng to rrubing asa sponse to ‘ices ting het nese Te tnt Deeves hat a tleton nenacastr a sercng har eet messoges and that he del ene wih oson aight while sho isleepng, She fret developed syrpoms at ge 25 ards had 7 preveus psyche hesptalators and 2 sue 20ers. Tiss ofhaoperorspedone and clanzzore have yes minal mpoverert. Her media codons nce hypereson ar ‘rid abety Pry examination snarl Medeaton herany wth dzapne inti Which ofthe long shel regi monte amis patent? ae Absotenewrephi cout zap Hood evel Placeeeeee ge eee ese peered Shs ee '42,yarld woman wh 2 stay of snzoptvena ought the ene by het patent te atengng to rrubing asa sponse to ‘ices ting het nese Te tnt Deeves hat a tleton nenacastr a sercng har eet messoges and that he del ene wih oson aight while sho isleepng, She fret developed syrpoms at ge 25 ards had 7 preveus psyche hesptalators and 2 sue 20ers. Tiss ofhaoperorspedone and clanzzore have yes minal mpoverert. Her media codons nce hypereson ar ‘rid abety Pry examination snarl Medeaton herany wth dzapne inti Which ofthe long shel regi monte amis patent? VA. sole newt ccut 5) 5. Ckeapine ond eve 1%) ©. Crest ee 1%) 3. Ecc ee) E Lvertunaon (5) Pee coun (6) Plc eve 18) H. Tyristnenen (1) mie ew ore ontsaze0 sone LW tear Toetred Binipeered A ee ‘Clozapine westmentguceines| Testmetsesan scizopveria Indesions + Senazptvenaasseaaat wh suc 7 agianuboose + seaues 1 Neca + Netabote snerome 2 | neseandgntn ase tp ane ate cone siete neem 22 Ul scene ws spent va pau asa, eset sy ra aren ps + || fepeetepomsesepe nearest arena Cespe bs} een eer C2 = || rete nang son eer cneprans onsen aren atone “ Neutropenia (<'000 czlis\mm*) and the poten! forMe-twestening agranulocytosis ave the major adverse elects of clazseine, The nek of 2) Seer esrnaey ete oreo nomna tes haa mph xaeae ‘Sul be soppedifreuropana ceca Seiwes an myocardtis are oer mpotant averse eet ta reauire prove vince (hole B) Cape pasma lvls canbe checked afer a inl target ose i reaches, butter dosage stusment ae usualy base.on CSc esponse. Cnzzire levels re not eat monies (cnoies Cand #) Creations lv ane yo ncn tts Shae be mena patients taking um ce otc’ etal 2 sverstafet thy a real incon. (rete Dy neu a basene ECO fequed and physians shel be aloe deepen of cardouasalar Symptons sugesive ot ‘myocar, rouine EG ate net equi. Anoag the second generation anipsychtcs,neredones macnn fer causing & roomed GT na (notes € nd) Live uc tery be ay lead he sec many paycotople mda, edn arctan ariconndcartsevembectopena canbe caused by ome arcantusars, However, rote menting over funcien et and plates isnotpee kde A ee agandbeytossis proce therefor vearentreqies regular monitoring he sens absolute newrophl count Teatrer ‘Sous be sappes eearopna ccous. Se2ues ans myacardis cher pra aaese ees at eque pore alance (Ghote 8) Cocaine asa evs can be check afer a ial ret ose is eachesbt futher dosage aeusments ae vsly bases on (Sei espe. Caran lvls re not reguty moore (Ghoies and M) Creatine eves an hyris fncion ss shoul te menor ipo taking tum ce to ths poeta to ‘ves afet hoi ar eal uncon. (hetee D) Atnoug a bascne E06 i equed and physicians shel be ale othe deelpment of carsovascareymptomssugesiv of mca rine EOGe are et requred. Among the second-generatonanopsychtcs,zerasone smash eta fer causrag 2 ringed GT inten (holes € an) Ler ncn tse ry iy elevats nt use ct many payeoapi meeaton,incsngarteyehebs an ariconvisrts:prbocyopena can be cause y some ariantulsars, However, route menoig over funcien etal sot requredtn comre (holes 6) Prtacin lvls ar netrourely maneres. Aron he second generation antpechots, spendene has been asscatee Wa geste fkof placin elevaton Eduestona objective: Pavers read wih czar are eared have reir mening tthe absohte new count de to he fishes agnor Reternens Phamacsoay PaychatielBehavorl &Stesarce Abuse Anpsichotcs|EO) CL Co .2-yeaoldman was espa ra paycate epee whe Naat yee of Goda land aleve at any wae plating {oxsnin He mproved rapty win medcaon therapy andas dicharged. Tee wees le he tl comes foe emegency deparment vet» gerraeod muecesithess and shaking ths nathan. He nas no cher medal hisor and akes no oer medications. Temperstre '5387 6 (8, Hood pressure 110180 mm Ha, pulse Bin, anc respraters ae nn. On ena status examina, Peis er and ‘reed wih i paranoid ro matory Rallis. Which fh flowing th es eater re pants caren por?6 a] GB .2-yeaoldman was espa ra paycate epee whe Naat yee of Goda land aleve at any wae plating {oxsnin He mproved rapty win medcaon therapy andas dicharged. Tee wees le he tl comes foe emegency deparment vet» gerraeod muecesithess and shaking ths nathan. He nas no cher medal hisor and akes no oer medications. Temperstre '5387 6 (8, Hood pressure 110180 mm Ha, pulse Bin, anc respraters ae nn. On ena status examina, Peis er and ‘reed wih i paranoid ro matory Rallis. Which fh flowing th es eater re pants caren por? ‘A Benevnine (52) 8. Danone 10%) ©. Dazepam . Halper a) Leeda (6) F Poprana () lotion rog:naueed parisons + 02 center bodes eeeee ge eee eserugindueed parkinsonism Ba ccertodes tology |» Arapyenoes Fist gereanon »szond generation + Anemeagesic molt apens eecomerazne,metodortamis) + Prominent gay & badness (slowed wovenon, deceased am ovina) ‘symotoms | + Trenor ies Aastra) 1 acted ces Meraoemert| | saucntnercs (unexyphenay benz) ‘This patente pyenoe episode was most hy esd wih an atpsychot, and his cue eympoms ste content wth drnduens parkinsonism an cxrayraical sce efect of armpschaecs Synpioms ince ng (nay be exerenced as subj shes) ‘resingpostrl tremor masked facies, = bragyineia ans typcal con tnn ees manta us ation Car napa ‘Se ees of anpsjcnate medications nce ante dion (sudden, susiaed ceracin of muss ups) and akan subecine estecsnes and aby to ti) ‘up nse parenson cause by dopamine (02) receptor blekade te ngrasreta pata Ie apsychate came reted or acorn, dundced parcreon bet este wit a cenaly acing andehoineri agente, berctcoe). Levoca ‘rou pat be used oust antpeychatc induced pakinsonsm as ican exacerbate or even rect payches (Chelee (Crees 8) Daren a rect acing stl musi rar ues a usta eure naga syne (NMS) BUS pases wm amuse usc gy, gh fever, smpaetchyperaciy (a, hypeisn,tcycarda), and eed mental sis and unity ins ‘onerte, feel tert wh nora val ans (Crotes Cand F) Meberzosarepne darenam ad beta Hck separ may bom bewsedn Me veament of kas. ANS Caracteied by subject estes and an abit sis athe than iy and emer, as seen in th pater. (reiee ) Haopencls 2st genaraton ampere ptet D2 Mocs ra equety cass extapyamdal syeloms nelaingpoe kde res ee se eects of anieychot mesieaons nue ate dona siden, sustained eracon of musce groups) and aks sbicive ‘estesanes and ay tt ‘rupindoces arensns is causes by dopamine (02 receptor blockade nthe nigrostriatal stay. ibe atpsycote carat be recede ecorud,dindced prtreonism bet eid ih x ena acing anehoineric agente, benrpe}. Lewosapt ‘tous pat be use oa! antpsycate ned pannsonsn can exacerbate reve reap pcs (heleeE) (hole B) Dancer isa rect acing stl muscle rant wen fe veatment of ewer nanan sycme (NMS) BIS preses wn tase usc gay, gh fv sympa hypesciy (a, hypeisin,tctycarta), and teed menial susan unity ins neta alee patet wh nara val Sn (Ghojes Cand F) Teberzosazcsne dazeoan andthe beta ck prepara may boh be wen he veament of akthisa, Mbisiais carat by sujecoe estes an an nadie 0 Saher an gay and emer a Seen ns pate (Chole D) aos sa rs-geneaton apc ard petet D2 Heke ha eave causes exapyraméa semen, ncaa Ineucedpavereonism suse would ery excess the pars person smmtoms, Use fs second-genertin arsychoe wih ‘meal 2 ocezde woud be a reserale ng tem tera the pallet wee tating WS genera antpsyhate ‘Eévetiona objective: ‘up induces parensnsm an en apyamia ss tect caused by medeabns ta ac 02 espns (9g antpyenas). Naragenent ‘stoeges nce decreasing dscontnung he oledng medaon and esnent wih an anelnerge medeton References 1+ Dau nda paransensn, Phamacsoay PaychatielBehavorl &Stesarce Abuse Anpsichotcs|Ss cee > EO) Ea Oe) ‘A 2ayacsld woman cams othe energene dearer eo ches an, dyspnea platen, peter rumbness, and sweating. Shes ‘eneraty anos and expan at ner sypors cane on suddenly fra apparent easn. The pallet has aa Sela epsodes Zor Sunes a ek forthe past sever moths Herblood pressures 1SO90 mmHg, us i 1DDmin and repraons ave 28min. Care anzyee ae noma and an EOG shewsnoralsrus hyn wth ro ST-segnentor-nave atnammaes, The pabentdagosea wih pane soe, She rece madeston andes tte the an hour When othe agung best decebes he mechan of cn fhe meen she OO tects poten sia tansiucton 2 8. Nes CARA meio = 6. e eneraly the GABA recep 2 5). competes wen GABA at ng te OE Prysaty noes melon chan nen OF Upreques cxBA receptor enstyeeeee ge eee ese eee ole @ fl be th eo ‘A 2ayacsld woman cams othe energene dearer eo ches an, dyspnea platen, peter rumbness, and sweating. Shes ‘eneraty anos and expan at ner sypors cane on suddenly fra apparent easn. The pallet has aa Sela epsodes Zor Sunes a ek forthe past sever moths Herblood pressures 1SO90 mmHg, us i 1DDmin and repraons ave 28min. Care anzyee ae noma and an EOG shewsnoralsrus hyn wth ro ST-segnentor-nave atnammaes, The pabentdagosea wih pane soe, She rece madeston andes tte the an hour When othe agung best decebes he mechan of cn fhe meen she ‘Mec poten signa anstucon (3) A Atos GABA meatier) ©: Bie atest othe GABA recep (0%) compas win GABA a tang te (75) Pryscaly blocks mean chant tunes (3%) FUpreguses GABA receptor dent (6%) nee tect hts loan GABA Areceptorhand GABAA receptor Qe tevctuzne sent age > eo GaBAA recopios 2 casa Benzodiazapine binding site the presence of GABA roeases oe? froquoney ofr chanel oping eo “The patent ext claaze slams of pate atck atta unspected nse of charters pce symp and negate esis wom. Ste mest nly recehesaberzedazcpine, 2 medcalon connor ase n emergency eng Decals I Odes a eae anit ‘enzosanspnes work ane GABA, (-aminaitye ace cep compl. GABA ste msin inhibin neurctanaminer need nervous asm andi nested tm dante van guar decarbon/ase The GABA, est corps conse 5 suis andaaioe it inves honor “This pasert exits dsc systems of parc atack abut ar urexpecied ese of characteris physica symtoms and regave mesic wert). Ste mest a recehesaberzedazcrine, 2 medcaton common used nemegoncy eng bacaise I reaes ap eo ale rue, Bennie: waka he GABAA (-ainautyc cd eeper comple. GABA & the main niin newctranamir cenit nevus system ands syteszed fom guanate wig quan decahow/ase. The GABA, cer cpt consi fs SWS a2 ‘ctl clone on hanna with tet deg ste or GABA and varus gs, berzodasepnes, barbie). Benodianypines aby ring tome terzedazepe bn so, hich llsteriealy modulates he binding of GABA, etrgm ninereased fecency oh Corde on channel opening. The fur f clone ns the neurons causes ewora hypepelaizatenandnheiten of Pe aon foetal Sri aca spare asters and wrk by pserging te dursion of channel opeingsn espns GABA ad t pte doss, 25 GABAA recep spon (hole A) GABA receptors medate the actors using tins. The sell muscle elaartbacbfen san explo dg that werk a 2 GH eepta agonist Berzaazepnes wor athe GABA. cea. (Ghote 8) Berzndazrpires dnc ater GABA meabssm. Cenan atbepletic mediation, inching vac acd anévgabat, econo (notes D) Berzoazeirs ont function tough cect cation che GABA. recep Ista, hey Wok 3 poste sinc meds that eromse an nesses Fecvency of chanel openings in respon to GABA simuton (tein E) Berzoazopnes dort uncton tough chap ofthe GABA reopen. Examples cf dugs tht dey tock he lmen of fon chanes nce amon tich fet epthelsosum charts nthe deal pron ofthereptven) and vera (acum carl Bice (hole F) Friongodbenzeiazepin use has bean shounto cause downregulation of GABA, eects and may be enecfthe mesarems by hich enzodazesine terance deveops.P a] GB AS Pa aera searae ae Titer doses, 0 ADA esp g (rcin A) GABA, recep: meds the aons wing pins. The see muce ean aca an earplect x hth wrk me 2 Gn recep agonist Beraaazepnes wor the GABAA cepa. (Ghote B) Berzodazcsives done ater GABA meabsm. Cen akeplepticmsieaions, incising val acd anéviabati, econo (choieeD) Berzosazrires ort funtion tough cet acatncfthe GABA recep Instead, hey Woks pose ste meds thatproese an nereases Fecvency of chanel openings in respon to GABA simuton (hole €) Senzoazopnes do ret function tireugh chap ofthe GABA reopen. Examples of ug hat recy tock neuen of Fon chanes chee amore tich fet eothela secu chars nthe dal pron ofthe retven) and vrapar (acum caret oder (Chote F) Froonged benzodiazepine use hasbeen shown cause downegutn of GABA. reece and may be cnecfthe mechanisms by Which erzodazein werance devon Educators cbective: ‘Senenazopnes aby ting tho berzosizeine bring ste, hich alostorcaly meds he ing of GABA, eur in an increased frequency coe on channel ering. The infu ef chaos ro he ners cases neuronal hyperpoarzabon andinhibton the acon potent Referens ‘+ Bereoarepne chamacoligy an cnalrencus tensed eos Phamacsoay Paychatie/Bebavorl Stesarce Abuse Berzdazeineseer es = m1 @ a] Ca es) ‘A 2ayea-old woman comes ote ce sting tessa alge Ad nab tl ri sll The pant was agrosed wh ‘serznpvena amen go ana medcatonerapy nas ined, He cose was creased SRer2 Weeks. SheSays, "Raver ead any YES ‘sce seu days sterne medesten vat erases Seon prestre i 4000 mm Hg anapuseie Oran The parte let ners foDe ancansovs.Wheh ofthe ffowings the nest ikey Sagres his alent? ‘A Rewedystona 8. Arar ©. Drg-nticed panseism © 0. Newreptemaiarantsmsrome OE Parcotcaptaton F Tae oneseeeee ge eee ese = as 6) > = per de Es Sd ee oe ‘A 2ayea-old woman comes ote ce sting tessa alge Ad nab tl ri sll The pant was agrosed wh ‘serznpvena amen go ana medcatonerapy nas ined, He cose was creased SRer2 Weeks. SheSays, "Raver ead any YES ‘sce seu days sterne medesten vat erases Seon prestre i 4000 mm Hg anapuseie Oran The parte let ners foDe ancansovs.Wheh ofthe ffowings the nest ikey Sagres his alent? A. pase toa) VO 8 Aeaia 71) ©. Drug-induced parinseism (7%) . Newlepte maignant sncome (2) . Poychatcaptaon (5) F Tae ones (8) tenton Important antpayehoe side eects + Rasa dystonic eacon Sudden anil ssaned meade contacions + Akasa Site restessness th niyo st it [erapyamia sie tectsae Important antiyshote ie eects + Aaa dystonic reactor Sudden anct soared musde contacions erapyamiéal sie atets | « scat. Sujere esessness hina 6 stil 1 Dnpnced prisons Tremor git acne, masked ie Trcive yekinesia | - elit movenanis tar civonic ae fp ipanacing, eeaahatald mavenants) Neuroepti maignantsyedrome | - For ity maria ss changes auonominsity “Ths patents experiencing aati, «ype oxrapyanidl sie cfecl associated wih artpechatcveament Aaa rages om mild ‘sitet eng fens to marks physical restseres (which canbe exe cictessea for patenis).ypcalyereseis dyst0 weeks afr iniisngatisrcheti eatret or ineasna he dese, Pains descibe an abit to str sandinene poston and may pace ‘raga a demonsratecderesess behaves. Teste’ opirs clue desea he acps}chte cose east) of Ueang ih 2 ea loce or erandazeores (hoiee A) ete dst an extrait se et characersd by ace aaa finlunary masse conten a he nck eh tongue oreye musces occurs we tousto das of ampyeha use especialy wah ped dos escalation oth ple, wSt-geneton artpoyences (a, oper), ands weated th anche medesten ep, ghennyacame,beztopne} (roie ) brug ized parsansm'san eapyemdal seat Yat esas wih cpu! gay aes tes, rayenen waner, ansdeceased am surg. eaters wsuahy win artcnotners (9, erzicpne) (hoje D) Newretcafaant sretome is an ace, ota fal eacon toaipychetceetors. Patent have hyper. Sympatatchyparacruty (eg tactyeasa daphress) Severe eas pp gy ae ated metal Sats (Ghote €) This part reports Pathe aur halucnations have reseed and shows no cher sors of psychoss. The physal restlessness cfakatnaamay be malate fr peychtcapnton. isp tc erent he ho etlagiee ae reeaang the artsychet one wl (hole F) Tarde dyskinesia is nrvlutary and potently reverse novenentdiorer to pconged antpeychotc expire (iala] GB SS it _invabes Nin Catuer ne “This parts experorcng aati, ype cf exranraicl sie efet assoosted wih artpschet reament Akasa rages fom mi ‘jet eng of ensen to marked phys essere (ich canbe exter cess fr patets). yal ereseis drsio weeks erating arpsyenetc eaiment ores he dase. Patents desde an abt Sr sananane poten an may Pace ‘equa a demonsrate cer esess behaves. Testnet opis clue decease atps}chate cose easble) of Ueang wih 2 bet loca or ersnsazepnes (rete A) tete aston an exrapyramia se tet characerze by acute esa of vitay mise conten of Meek aun, tongue oreye muscles. occurs wii howsto days of antpychac use especialy wth apd dos escalation oth pte, it gneation arpoyences (eg, heepero), ane Weta wth anchenericredesten ep, Aponnyaamine,becropne) (rete brug ice parsonsmis an tanjamda seat a presents win cones gay mashed aces banpenesa Yenc, anddeceased am surg. Treatnetis wud with atchotnarges (9, berzepee). (reiee D) Newrsememesgnan! syateme an act, potty fal eacton inarpsyehemedeaters. Patan have ypemema sympatbetc hyperacute, tactyearaa daphoreis) severe "ead png ae aed metal ats {hoie E) Ths pater athe aur halucnstens haverezcied anshowe nother ats af pychoss. The phys eteezness ct akansa may be mstaen fo p5/cetcaplaon. Ms pata o aerite evo etloges as easing te artpsyenc ose wll fone eacetate aaa (noiee F) Tau asin an rua an getemany steele veranda ato pong antpsycate expe (ypeay yes) Characersic ovens nelaelip smacking tng gman, longue proses, and coesaead movers tie ess, kts onsturk, Eduestons objective: ‘Achaia an wary ie efecto repayenaie mecca hacen net estes anda nab tartan ane postion Treimertimahes aredusen he antpyeho dose, # possi, ore aden of beaker berzodiazenin + Drupindod akanSS) ae Lame OL) | dbyear-cldworan comes othe oles fr alu oa ood std Te tert nak a Nay of several depres epaodes at staan rertwenies Two yar ag, she was bosptalzed aerial up Seve nigh Wout eepng nd clam at she had spec powers "nd gleblpoery ard ciate change” Her symptoms respond woo wetmert ar she as reine nthe sams dug regen since then. Hones the pater ron tas new-nsetcrsteatn, ry sin nt har less. She'salsoconeemed about weit gan 227 ka (1) cette at 3-4 monte detecting eal lou.clifeace lad preasreie M0710 mem Hare pues SSmn. The pate ppears, Wed, ttpyscal examinabn scenwsenomal. Te apr exashed nde curent cae atte avese ee TOM cnecthermedcatons. Wich fhe lowing isthe mst alc dug?6 a] GB | dbyear-cldworan comes othe oles fr alu oa ood std Te tert nak a Nay of several depres epaodes at staan rertwenies Two yar ag, she was bosptalzed aerial up Seve nigh Wout eepng nd clam at she had spec powers "nd gleblpoery ard ciate change” Her symptoms respond woo wetmert ar she as reine nthe sams dug regen since then. Hones the pater ron tas new-nsetcrsteatn, ry sin nt har less. She'salsoconeemed about weit gan 227 ka (1) cette at 3-4 monte detecting eal lou.clifeace lad preasreie M0710 mem Hare pues SSmn. The pate ppears, Wed, ttpyscal examinabn scenwsenomal. Te apr exashed nde curent cae atte avese ee TOM cnecthermedcatons. Wich fhe lowing isthe mst alc dug? 1 Cotemazeine (3) 5 ctaopam 2%) ©. Cezanne (15%) . Lamongine (%) vO tatu 6) F Reprone (2) 6 Trazodone (16) st 2 secs osra072020 oe No a = —) ‘Mood stabilizers in bipolar disorder Inston ‘svar oe | > Das ies Limam — |» Wan eoressne features, | * THPewnedsn + Eisen anny fee) vaio | aeons ay + Nernon es atone) 7 Aas en atoms | «Maries {shoe + Nernst tone) Lameetgne |= Sqpesnetsaues | Senenanh : + Steen tain yedone “SADM yntoe chappoptsaeichermone secon ‘Tas posers wept gan, alos, ara md rachael te most ly dt urn inaiced hypothyr. LMU a mood saa prmariy wed ne veamentofiplr doer ites cause hypetyreidam oy rtoerng whom sree and eleas of tyro hhomone. Theconpenssy ease in TSH lease y th pula can ado gen seme patents. Liuenciced pays is treed th starr estrone (Td) eplacament addon a esate corinne ea Longer thom therapy is ao associ wth aes fe on real uncon eg, nephrogenic eabetes Insp, chronic uber nechropahy) equi reguarmeiting of oe tum eres ard rena fincen (ood weaivegen ad resin) Liu use dung6 a] GB Prgrare as been aoc wth Eesti anomaly oft teu whe bute abot nes sa (choles Aand 0) Caarazssing and lasing se amconmlsans tht are aio vee cna tablcers im pln eoger Cateamazeprneconcauseapasic anemia. Lamers assccaied wt) akcf ash, ung roel ie-freatenny Stevenson (notes 8) Citalopram 3 select serotnn eutake nity (SSRI aniderressant.Sowaldysuncton che most commoner cide feck. SSRIs re net used as monotrapyin Beda dors and are ot assoc wih hypohyoim. (hole) Czseie = etcant-gneratenarteychae nates er tesmnertretacay shzoptreia ascetes wi arandceyee and reautes requir menting cf he ascuterewreti count. Alheugh cezapne can cause wegh gain and constipation, tino ete ‘resnent or need disorders ard woud rat enn spatter hypetyrod fares en ski, hos, rahcada) (Chole F) Fispndone ism eecons.genraonartesyehete tat can ease sight an an yparracinema (en, gests, amenertes) spot assecated th pohrosr, (hele 6) Tazedon isan anopressant at has signfcant sedating essa isos conronly used sweat Gepesion ated Insernia One adverse fect ioe pass longed pan recton) and anshoinerge eet (eh mah, const) Educational ebective: trypathrodism nd nepiregenc Sabet isipus ae he most commen adore ees oflongem Hum therapy. Sen TSH and rena foncton (6003 wearitege ad reamine) shoud bereits ttre Phamacoogy syhamcISehavoral a Stestarce Abuse HypanyaisnEO) CL Co '.2¢-yeaold mans hospalzed ater avin epsndein wc he desteyed see vson wih a baetil bat. Oven pst yea he patent as cnnced at pple on eevion were motion hs heh and Raveners ans hat catannewscasrs were laughing at AL ‘none ns was unio sae anaes neanrg he vce of mons wentenng tl hen. Tha patents agrees onaoonens| ancintiay wea wih hioprormzne. He now's eluant tae he mediation sayng "eit ke how makes me fee” Hs mediate is ‘nbrequrt changed te fuphenazne. Corparedtothe patents ml Yesnert fuprenarne is more el cause whenfhe aun?6 a] GB '.2¢-yeaold mans hospalzed ater avin epsndein wc he desteyed see vson wih a baetil bat. Oven pst yea he patent as cnnced at pple on eevion were motion hs heh and Raveners ans hat catannewscasrs were laughing at AL ‘none ns was unio sae anaes neanrg he vce of mons wentenng tl hen. Tha patents agrees onaoonens| ancintiay wea wih hioprormzne. He now's eluant tae he mediation sayng "eit ke how makes me fee” Hs mediate is ‘nbrequrt changed te fuphenazne. Corparedtothe patents ml Yesnert fuprenarne is more el cause whenfhe aun? Cconsteaten 2%) Dearss 8) ry mouth 5) peice (1%) Museu ig (60%) Seaaten (1%)aioe De Firatgeneration antipsyshotios side eects a Sie eects GEES voupuney “+ Seon istanieige Hocac) + cherpremazine paw |_|» Artcholnegie ade fects (hoinepe Blockade) + Thorkanne (monneuciogea | «orotic ypciensen aha atreneri tock) | Exrapyramda symstons + Act dystonia ee Hioh-potency a0 potency (neurciegiea)| 7 Pose IS + Fiphenazine Fst gneton asics (FA) aso known 3s ypc of coneronal arpa, are elecvein Weta schaophena ae psychi: Guetoother causes. FCA are cise according te poeny which refers othe dose reat erode an eet. Lew-pteney FAS fatty use Meaminergi, ehalntple até nereranegieBlskade se ess These gs me gh seaaing aan case aticolnee se eects and cmos hyolenson Highpeteney FGA ae assoc pay wi extrapyramidal smetons ‘json, kas parinsonem) du to pote 2 dopamine receptor antagonism nthe nro pathy ‘Tas pasts meacaton was changes tom alow patncy FGA (chypronaze) oa gh ptency FOR (Rupenazne). Muscular gay 2n manana se afc seen in up-nauced paieonsm is more Ike occur Wa Ngh-pctngy eet (hoies AC, and.) Compt, dy math and nay fterion are achalasia de toch recat ockade: They are marecomman win ow ecseney attests Ober ankraierg sce fects cde sre ion ad impated cognve ncn. (hole B) Dzzness and ohosiic prensn ae due to alpha adkeneic blade al are ore commen wth ow slency FAS (Onrastan hyetenion spac prouenanc n Peery ave tothe ketal (Ghote D) Hyperiycema sa meal se fect seen mare career wih seconé- generation apse GBSE ps = 6 a] GB Jon wor caves. FORe ae Cacesed aceXGng to peeny whch eee Be ae reeuted ores an eect Low-poeney FORe - - prvaiy cause histamine, cholnergle and noradrenergic blockade sce fs. These gs ze hgh sedaig aon caso anche ie efecs and omtstaichypteson. Highpeteney FGAs ea: pari wih extrapyramidal symetoms (3, (jsona, aka parsons) due pster 2 doparane recep’ antagonism te ngfosai away “Thispaserts mecca was changes om aleepstency FGA chlerpronazr)toahih-stency FGA futherazne). Muscular icy 2n apa ae fect anon ug ned prkacnam ie mote lly Soest a hghpstency age (holes AC, and 6) Constptn, dy meth and nay reterten are atcha side fects de toch recetrckade. They ‘area conmon wih lowscsene arteschces. Other anchainergc sie fects nce ured sion and imped conse ncn. (hele 8) Dzzness an otostatc hpctunsin are deo apt adenatic Bokade and are are conman with ew tency FAS. ‘Ontos hiptesion spac protic rte ery veo he rik als (cnoie D) Hyperyema sa meabole ss fect sen mae coment wih seconégeeratin snipers (ChoieeF) Seaton isd tohitanne recep Hsieh moe conman ith iu plency artpychotcr ‘Education objective: Fist.geeaon assoc can be clase ccorcng high elev potency andhave characte side eet poles. Lowoteney aripoyences re mae ayo case seca artealnege ie elec ard ome hyatension Hah pen pyc ae rae ay a couseextapyamaasymetans ee, dione, akan, parsons). References + Fugen open crs ow plecy is geetaon arapyeh gs + Comparative efiacy ane erat o IS anipsychotcrigein chapter a mulplsteeiments metpara Phamacsoay PaychatielBehavorl &Stesarce Abuse Anpsichotcs|