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drug to minimize toxic side effects; achieving at least additive, multi-targeting
effects, or even “greater-than-additive” effects, so called synergy; and reducing
the likelihood of treatment resistance. However, even with the advanced high-
throughput technologies currently used in drug combination screening, it remains
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2*7##!(

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2*8##!(

FIDFJKD8C@>E8EK;@J<8J<JJL:?8J:8E:<I;I@M<E9P:FDGC<ODFC<:LC8I8E;
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.?<I<=FI<:FD9@E@E>;IL>JNFIB@E>8>8@EJKdifferent molecular mechanisms has
become increasingly popular in cancer treatment. The primary goals of
combination therapy are: 1) reducing the dose of each single drug to sufficient
response level to minimize the toxic side effects; 2) achieving at least additive
effects or even “greater-than-additive” effects, so called synergy, in the
biochemical activities of two drugs; 3) modulating selectively on activity of
targets found in tumor cells but not in healthy cells; and 4) reducing the
likelihood of drug resistance (Fitzgerald et al., 2006; Al-Lazikani et al., 2012).
. %! $

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N?<I< @JK?<I<JGFEJ<8=K<I8;;@E>;IL>KF;IL> λ @JK?<JCFG<F=K?<
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9<:FD<J

λ

#EK?<J8D<N8PK?<<OG<:K<;I<JGFEJ<F=8;;@E>;IL> KF;IL>9<:FD<J

λ

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@E8KNF N8PD8EE<I8JN<CC

λ

λ

#E4#*DF;<C8;<CK8J:FI<@J;<=@E<;KFHL8EK@=PK?<FM<I8CCGFK<E:PJ?@=K

"#

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@EK<>I8K@FEF=K?<J<KNFJPEPDF;<CJ

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;@J8;M8EK8><J

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LJ<;8JK?<GI<;@:K<;JPEPJ:FI<

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I8K?<IK?8E8>CF98CFGK@D8

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Copyright:

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