GENOME-EXPOSOME

INTERACTION
Gene-Environment Interaction

Environment

Genetic
SOURCE
Gwinn M, Guessous I, Khoury MJ. Invited commentary: genes, environment, and hybrid
vigor. Am J Epidemiol. 2009 Sep 15;170(6):703-7
 Omic Interaction

Exposome

Genome
Genomic Individualized
medicine Precision medicine
medicine
 GxE Gene Environment Disease
interaction XP UV Xeroderma pigmentosum

Phenylalanine hydroxylase Phenylalanine phenylketonruia

APOE4 Untreated HTA Cognitive decline

CCR5 HIV Taux d’infection HIV

MTHFR Folic acid intake Colorectal cancer if folate

deficiency

PPARG2 Fat intake Obesity

GRS diabetes Air pollution Diabetes

Gene related to oxdative Irritants Asthma

stress

Gene related to Asthma Smoking Asthma

Gene large panel Alcohol, smoking CRC

SOURCE
Références des sources ou images présentées

SOURCE
http://creativecommons.org/licenses/by/4.0/