PMID- 31152867

OWN - NLM
STAT- MEDLINE
DCOM- 20200709
LR - 20200709
IS - 1879-260X (Electronic)
IS - 0925-4439 (Linking)
VI - 1866
IP - 2
DP - 2020 Feb 1
TI - Altered maternal metabolism during mild gestational hyperglycemia as a
predictor
of adverse perinatal outcomes: A comprehensive analysis.
PG - 165478
LID - S0925-4439(19)30174-7 [pii]
LID - 10.1016/j.bbadis.2019.05.014 [doi]
AB - Mild gestational hyperglycemia (MGH), as assessed using the normal oral
glucose
tolerance test (OGTT) and detection of an altered glycemic profile, is
associated
with adverse perinatal outcome. This study described the results of 40 years
of
research conducted at the Perinatal Diabetes Research Centre at São Paulo
State
University (UNESP), Brazil, on the maternal MGH environment and placental
markers. This study also described the unidirectional relationship between
MGH
and excessive fetal growth, also supplying moderator analysis. In addition to
hyperglycemia, MGH is associated with an increased incidence of hypertension,
metabolic syndrome, persistent insulin resistance after pregnancy, and high
risk
of developing type 2 diabetes mellitus (T2DM) after pregnancy. Structural
changes
and functional abnormalities resulting from MGH were observed in placenta.
The
fully adjusted model concluded that the predictor variable (MGH), which
creates a
complex environment for the fetus, has a direct effect on excessive birth
weight
and produces a z-score for ratios of birth weight to gestational age of ≥2.
Maternal age, pre-pregnancy BMI, number of previous pregnancies, numbers of
prenatal visits, and 1 h OGTT are moderator variables that impact MGH and
excessive fetal growth. These results show that maternal MGH has some
characteristics associated with similar long-term T2DM development and
similar
adverse perinatal results to those of gestational diabetes mellitus (GDM)
mothers, making it an intermediate maternal and placental marker between
normoglycemic and GDM mothers.
CI - Copyright © 2019 Elsevier B.V. All rights reserved.
FAU - Rudge, Marilza Vieira Cunha
AU - Rudge MVC
AD - Department of Gynecology and Obstetrics, Botucatu Medical School (FMB), São
Paulo
State University (UNESP), CEP18618-687, São Paulo, Brazil; Graduate Program
in
Gynecology, Obstetrics, and Mastology, Botucatu Medical School (FMB), São
Paulo
State University (UNESP), São Paulo, Brazil. Electronic address:
marilzarudge@gmail.com.
FAU - Barbosa, Angélica Mercia Pascon
AU - Barbosa AMP
AD - Graduate Program in Gynecology, Obstetrics, and Mastology, Botucatu Medical
School (FMB), São Paulo State University (UNESP), São Paulo, Brazil;
Department
of Physiotherapy and Occupational Therapy, School of Philosophy and Sciences,
Marília, São Paulo State University (UNESP), São Paulo, Brazil.
FAU - Sobrevia, Luis
AU - Sobrevia L
AD - Graduate Program in Gynecology, Obstetrics, and Mastology, Botucatu Medical
School (FMB), São Paulo State University (UNESP), São Paulo, Brazil; Cellular
and
Molecular Physiology Laboratory (CMPL), Department of Obstetricia, Division
of
Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine,
Pontificia
Universidad Católica de Chile, Santiago 8330024, Chile; Department of
Physiology,
Faculty of Pharmacy, Universidad de Sevilla, Seville E-41012, Spain;
University
of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and
Biomedical Sciences, University of Queensland, Herston, QLD 4029, Queensland,
Australia.
FAU - Gelaleti, Rafael Bottaro
AU - Gelaleti RB
AD - Graduate Program in Gynecology, Obstetrics, and Mastology, Botucatu Medical
School (FMB), São Paulo State University (UNESP), São Paulo, Brazil.
FAU - Hallur, Raghavendra Lakshmana Shetty
AU - Hallur RLS
AD - Graduate Program in Gynecology, Obstetrics, and Mastology, Botucatu Medical
School (FMB), São Paulo State University (UNESP), São Paulo, Brazil.
FAU - Marcondes, João Paulo Castro
AU - Marcondes JPC
AD - Graduate Program in Gynecology, Obstetrics, and Mastology, Botucatu Medical
School (FMB), São Paulo State University (UNESP), São Paulo, Brazil.
FAU - Salvadori, Daisy Maria Fávero
AU - Salvadori DMF
AD - Department of Pathology, Botucatu Medical School (FMB), São Paulo State
University (UNESP), São Paulo, Brazil.
FAU - Prudêncio, Caroline Baldini
AU - Prudêncio CB
AD - Graduate Program in Gynecology, Obstetrics, and Mastology, Botucatu Medical
School (FMB), São Paulo State University (UNESP), São Paulo, Brazil.
FAU - Magalhães, Claudia Garcia
AU - Magalhães CG
AD - Department of Gynecology and Obstetrics, Botucatu Medical School (FMB), São
Paulo
State University (UNESP), CEP18618-687, São Paulo, Brazil.
FAU - Costa, Roberto
AU - Costa R
AD - Department of Gynecology and Obstetrics, Botucatu Medical School (FMB), São
Paulo
State University (UNESP), CEP18618-687, São Paulo, Brazil.
FAU - Abbade, Joelcio Francisco
AU - Abbade JF
AD - Department of Gynecology and Obstetrics, Botucatu Medical School (FMB), São
Paulo
State University (UNESP), CEP18618-687, São Paulo, Brazil.
FAU - Corrente, José Eduardo
AU - Corrente JE
AD - Biostatistics Department, Bioscience Institute, São Paulo State University
(UNESP), São Paulo, Brazil.
FAU - Calderon, Iracema de Mattos Paranhos
AU - Calderon IMP
AD - Department of Gynecology and Obstetrics, Botucatu Medical School (FMB), São
Paulo
State University (UNESP), CEP18618-687, São Paulo, Brazil; Graduate Program
in
Gynecology, Obstetrics, and Mastology, Botucatu Medical School (FMB), São
Paulo
State University (UNESP), São Paulo, Brazil.
CN - Perinatal Diabetes Research Group
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
PT - Review
DEP - 20190530
PL - Netherlands
TA - Biochim Biophys Acta Mol Basis Dis
JT - Biochimica et biophysica acta. Molecular basis of disease
JID - 101731730
RN - 0 (Biomarkers)
RN - 0 (Blood Glucose)
RN - 0 (Cytokines)
RN - 0 (IRS1 protein, human)
RN - 0 (Insulin Receptor Substrate Proteins)
SB - IM
MH - Biomarkers
MH - Birth Weight
MH - Blood Glucose/metabolism
MH - Cytokines/metabolism
MH - Diabetes Mellitus, Type 2
MH - Diabetes, Gestational/diagnosis/genetics/*metabolism
MH - Female
MH - Gene Expression
MH - Glucose Tolerance Test
MH - Humans
MH - Hyperglycemia/*complications/genetics/*metabolism
MH - Hypertension
MH - Insulin Receptor Substrate Proteins/genetics
MH - Insulin Resistance
MH - Metabolic Syndrome
MH - Pregnancy
OTO - NOTNLM
OT - Apoptosis
OT - Cytokines
OT - Gene expression
OT - Gestational diabetes mellitus
OT - IRS-1 gene
OT - Inflammatory mediators
OT - Insulin resistance
OT - Large for gestational age
OT - Mild gestational hyperglycemia
OT - Moderator analysis
OT - Natural killer cells
OT - Placenta
EDAT- 2019/06/04 06:00
MHDA- 2020/07/10 06:00
CRDT- 2019/06/02 06:00
PHST- 2018/10/07 00:00 [received]
PHST- 2019/05/18 00:00 [revised]
PHST- 2019/05/22 00:00 [accepted]
PHST- 2019/06/04 06:00 [pubmed]
PHST- 2020/07/10 06:00 [medline]
PHST- 2019/06/02 06:00 [entrez]
AID - S0925-4439(19)30174-7 [pii]
AID - 10.1016/j.bbadis.2019.05.014 [doi]
PST - ppublish
SO - Biochim Biophys Acta Mol Basis Dis. 2020 Feb 1;1866(2):165478. doi:
10.1016/j.bbadis.2019.05.014. Epub 2019 May 30.