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An Insider’s Guide to
CLINICAL MEDICINE
An Insider’s Guide to
CLINICAL MEDICINE
Archith Boloor
MBBS MD (Internal Medicine)
Associate Professor
Department of Medicine
Kasturba Medical College
Manipal Academy of Higher Education
Mangaluru, Karnataka, India
archithb@gmail.com
Anudeep Padakanti
MBBS MD (Internal Medicine)
Department of Medicine
Kasturba Medical College
Manipal Academy of Higher Education
Mangaluru, Karnataka, India
anudeeppadakanti.aigcm@gmail.com
Foreword
Chakrapani M
Headquarters
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© 2020, Jaypee Brothers Medical Publishers
The views and opinions expressed in this book are solely those of
the original contributor(s)/author(s) and do not necessarily represent
those of editor(s) of the book.
All rights reserved. No part of this publication may be reproduced,
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An Insider’s Guide to Clinical Medicine
First Edition: 2020
ISBN 978-93-89587-87-6
Printed at
In fond memory of
Dr Sitamahalakshmi
Foreword
Chakrapani M MD
Professor
Department of Medicine
Formerly, Head and Associate Dean
Kasturba Medical College
Manipal Academy of Higher Education
Mangaluru, Karnataka, India
chakrapani.m@manipal.edu
Preface
The clock had struck a solid 1:30 PM. The examiner was hungry, the
last student was jittery and in between them lay a central nervous
system (CNS) case that was going to determine whether a four-and-
half-year ripe child of medicine would be prefixed with a “Dr” or not.
The examiner was more bored than he could care to admit.
Lakshman, aged 32, hailing from Shivamogga, Karnataka with chief
complaints of bilateral lower limb weakness was being presented for
the 14th time that day. The same boring questions had been asked
in the same uninspired fashion.
“List the causes of neck pain”, the examiner asked.
A little taken aback but the student realized that the question was
within the realm of a CNS case. After gathering his thoughts for a
moment, he began listing out, “Meningitis causing neck muscle
spasm, cervical spondylosis, cervical spondylolisthesis...” his voice
trailing off in response to the examiner’s unimpressed face.
”Go ahead, what else?”
Not to lose face in front of the examiner, the student once again
reset his thoughts, and a few umms and ahhs later continues:
”Sir, other cervical causes like cervical intraepithelial neoplasia,
cervical cancer, etc. can also cause neck pain”.
Archith Boloor
Anudeep Padakanti
Remembering the Father of Modern
Medicine
Every patient you see is a lesson in much more than the malady
from which he suffers. Listen to your patient. He is telling you the
diagnosis.
The good physician treats the disease; the great physician treats the
patient who has the disease.
We are here to add what we can to life. Not to get what we can from
life. Too many men slip early out of the habit of studious reading and
yet that is essential.
Acquire the art of detachment, the virtue of method and the quality of
thoroughness but above all the grace of humility.
Index
Abbreviations
°C : Degree celcius
°F : Degree Farenheit
ALL : Acute lymphoblastic leukemia
ABPA : Allergic bronchopulmonary aspergillosis
ACS : Acute coronary syndrome
ACR : American college of Rheumatology
ARF : Acute renal failure
ADHD : Attention deficit hyperactivity disorder
ADR : Adverse drug reaction
ARDS : Acute respiratory distress syndrome.
AGN : Acute glomerulonephritis
AION : Anterior ischemic optic neuritis
AKI : Acute kidney injury
ALL : Acute lymphoblastic leukemia
ASCVD : Atherosclerotic cardiovascular disease
ACD : Anaemia of chronic disease
ADC : Apparent diffusion coefficient
ACA : Anterior cerebral artery
ACE : Addenbrooke’s cognitive examination
ACEI : Angiotensin converting enzyme inhibitor
ARB : Angiotensin receptor blocker
ACTH : Adrenocorticotropic hormone
ADHF : Acute decompensated heart failure
AEM : Ambulatory electrocardiogram monitoring
AI : Aortic insufficiency
AIDP : Acute inflammatory demyelinating polyneuropathy
AF : Atrial fibrillation
AICA : Anterior inferior cerebellar artery
AICD : Automated implantable cardioverter defibrillator
AML : Acute myeloid leukemia
ANS : Autonomic nervous system
ARVD : Arrhythmogenic right ventricular dysplasia
ASD : Atrial septal defect
AVF : Arteriovenous fistula
AVM : Arteriovenous malformation
AVR : Aortic valve replacement
AVRT : Atrioventricular re-entrant tachycardia
AVNRT : AV nodal re-etrant tachycardia
APB : Atrial premature beat
ALS : Amyotropic lateral sclerosis
ADL : Activities of daily living
ACPA : Anticitrullinated protein antibody
APLA : Antiphospholipid antibody syndrome
AP : Anteroposterior
Bx : Biopsy
BAL : Bronchoalveolar concentration
B/L : Bilateral
BIH : Benign intracranial hypertension
BAV : Bicuspid aortic valve
BBB : Bundle branch block
BC : Bone conduction/blood culture
BCAT : Brief cognitive assessment tool
BER : Benign early repolarization
BLS : Basic life support
BSA : Body surface area
BP : Blood pressure
BT : Bleeding time
BUN : Blood urea nitrogen
BM : Bone marrow
BMI : Body mass index
BMV : Bag and mask ventilation/balloon mitral valvotomy
BVP : Biventricular pacing
B-ALL : B-cell acute lymphoblastic leukemia
BADL : Basic activities of daily living
CRP : C-reactive protein
CXR : Chest X-ray
CCA : Common carotid artery
C/L : Contralateral
CMT : Charcot Marie tooth Disease
CN : Cranial nerve
C/O : Complaints of
CT : Computed tomography
CAMCOG : Cambridge cognitive examination
COST : Cognitive state test
CPR : Cardiopulmonary resuscitation
CCF : Congestive cardiac failure
CHF : Congestive heart failure
CBC : Complete blood count
CBD : Common bile duct
CHB : Complete heart block
CKD : Chronic kidney disease
CIDP : Chronic inflammatory demyelinating polyneuropathy
CLD : Chronic liver disease
CLL : Chronic lymphoid leukemia
CML : Chronic myeloid leukemia
CMV : Cytomegalovirus
CNS : Central nervous system
CVA : Cerebrovascular accident
CNS : Central nervous system
CABG : Coronary artery bypass graft
CAD : Coronary artery disease
CAUTI : Catheter associated UTI
CBE : Clinical breast examination
CRF : Chronic renal failure
COPD : Chronic obstructive pulmonary disease
CCCU : Critical coronary care unit
CCS : Canadian cardiovascular society
CVS : Cardiovascular system
CVP : Central venous pressure
CP angle : Cerebellopontine angle
CPB : Cardiopulmonary bypass
CDC : Centers for disease control and prevention
CDAI : Clinical disease activity index
CGA : Comprehensive geriatric assessment
CSF : Cerebrospinal fluid
DDx or D/D : Differential diagnosis
DPI : Dry powder inhaler
DIC : Disseminated intravascular coagulation
DIP joint : Distal interphalangeal joint
DKA : Diabetic ketoacidosis
DLCO : Diffusion lung capacity for carbon monoxide
DM : Diabetes mellitus
DR : Diabetic retinopathy
DNR : Do not resuscitate
DTR : Deep tendon reflex
DTA : Descending thoracic aorta
DSM : Diagnostic and statistical manual of mental disorders
DVT : Deep venous thrombosis
DLE : Disseminated lupus erythematosus
DAS : Disease activity score
DWI : Diffusion weighted imaging
ECA : External carotid artery
EAT : Ectopic atrial tachycardia
ECG : Electrocardiogram
ECF : Extracellular fluid
ECHO : Echocardiogram
ECMO : Extracorporeal membrane oxygenation
EPS : Extrapyramidal system
EF : Ejection fraction
EM : Erythema multiforme
ECD : Endocardial cushion defects
EDH : Extradural hematoma
EOM : Extraocular muscles/movement
EPO : Erythropoietin
EDM : Early diastolic murmur
ESM : Ejection systolic murmur
ESRD : End-stage renal disease
ET : Endotracheal tube
ESV : End-systolic volume
EULAR : European league against rheumatism
FMS : Fibromyalgia syndome
FBS : Fasting blood sugar
FEV1 : Forced expiratory volume in first second
FTT : Failure to thrive
FVC : Forced vital capacity
GI : Gastrointestinal
GBS : Guillain–Barré syndrome
GCS : Glasgow coma scale
GERD : Gastroesophageal reflux disease
GH : Growth hormone
Hb : Hemoglobin
HMF : Higher mental functions
HOCM : Hypertrophic obstructive cardiomyopathy
HBV : Hepatitis B virus
HL : Hodgkin lymphoma
HUS : Hemolytic uremic syndrome
HAI : Hospital acquired infection
HE : Hepatic encephalopathy
HDS : Hemodynamically stable
HIT : Heparin induced thrombocytopenia
HCC : Hepatocellular carcinoma
HTN : Hypertension
HIV/AIDS : Human immunodeficiency virus/acquired immunodeficiency syndrome
HDL : C-High density lipoprotein cholesterol
HD : Huntington’s disease
IADL : Instrumental activities of daily living
IP joint : Interphalangeal joint
IGF : Insulin-like growth factor 1
ICA : Internal carotid artery
ICD : Intercostal drain
ICS : Intercostal space/inhaled corticosteroid
ICH : Intracerebral hemorrhage
IVH : Intraventricular hemorrhage
INO : internuclear ophthalmoplegia
INR : International normalized ratio
ICP : Intracranial pressure
IBD : Inflammatory bowel disease
IBS : Irritable bowel syndrome
IDDM : Insulin-dependent diabetes mellitus—Type 1 diabetes
ICSOL : Intracranial space occupying lesion
IHD : Ischemic heart disease
IJV : Internal jugular vein
ILD : Interstitial lung disease
IMN : Infectious mononucleosis
IVC : Inferior vena cava
INH : Isoniazid
IPPV : Intermittent positive pressure ventilation
ITP : Immune thrombocytopenic purpura
IV : Intravenous
JME : Juvenile myoclonic epilepsy
JRA : Juvenile rheumatoid arthritis
JVP : Jugular venous pressure
KUB : Kidney, ureters and bladder
KDIGO : Kidney disease improving global outcomes
KF Ring : Kayser fleischer ring
LSM : Late systolic murmur
LV : Left ventricle
LVH : Left ventricular hypertrophy
L\A : Local anesthetic
LDL : C-Low density lipoprotein cholesterol
LP : Lumbar puncture
LMN : Lower motor neuron
LVE : Left ventricular enlargement
LVF : Left ventricular failure
LOC : Loss of consciousness
LQTS : Long QT syndrome
LGIB : Upper gastrointestinal bleed
MAP : Mean arterial pressure
MAT : Multifocal atrial tachycardia
MoCA : Montral cognitive assessment
MMSE : Mini-mental state examination
MCA : Middle cerebral artery
MCP joint : Metacarpophalangeal joint
MDS : Myelodysplastic syndrome
MDM : Mid-diastolic murmur
MLF : Medial longitudinal fasciculus
MND : Motor neuron disease
MS : Mitral stenosis/multiple sclerosis
MVP : Mitral valve prolapse
MVR : Mitral valve replacement
MSA : C-Multisystem atrophy—cerebellar
MSA : P-Multisystem atrophy—Parkinson’s
MCTD : Mixed connective tissue disease
MI : Myocardial infarction
MRC : Medical research council
mMRC : Modified medical research council
MRI : Magnetic resonance imaging
MDI : Metered dose inhaler
MODS : multiorgan dysfunction syndrome
NHL : Non-Hodgkin lymphoma
NASH : Non-alcoholic steatohepatitis
NCV : Nerve conduction velocity
NMJ : Neuromuscular junction
NPPV : Noninvasive positive pressure ventilation
NPH : Normal pressure hydrocephalus
NTS : Nucleus Tractus solitarius
REM : Rapid eye movement
NREM : Non rapid eye movement
NST : Non-stress test
NSTEMI : Non-ST-Elevation myocardial infarction
NSAIDs : Nonsteroidal anti-inflammatory drugs
NYHA : New York heart association
NG Tube : Nasogastric tube
O/E : On examination
OSA : Obstructive sleep apnea
OA : Osteoarthritis
OP : Organophosphorus
PA : Posteroanterior
PAN : Polyarteritis nodosa
PDA : Patent ductus arteriosus
PAH : Pulmonary Artery Hypertension
PCI : Percutaneous Coronary Intervention
PCA : Posterior cerebral artery
PCV : Packed Cell Volume
PCWP : Pulmonary Capillary Wedge Pressure
PD : Parkinson’s Disease
PE : Pulmonary Embolism
PEEP : Positive End Expiratory Pressure
PEFR : Peak Expiratory Flow Rate
PAH : Pulmonary Artery Hypertension
PIP Joint : Proximal interphalangeal joint
PICA : Posterior inferior cerebellar artery
PLS : Progressive Lateral Sclerosis
PND : Paroxysmal Nocturnal Dyspnea
PUO/FUO : Pyrexia (fever) of Unknown Origin
PVC : Premature Ventricular Contractions
pO2/paO2 : Partial pressure of oxygen
paCO2 : Partial pressure of carbon dioxide
PMI : Point of maximal impulse
PPBS : Post-prandial Blood Sugars
qSOFA : Quick sequential organ failure assessment
QSART : Quantitative sudomotor axon reflex test
RA : Rheumatoid Arthritis
RF : Rheumatoid factor
RAI scan : Radioactive iodine scan
RAS : Reticular activating system
RAPD : Relative apparent pupillary defect
RCM : Restrictive cardiomyopathy
RCC : Renal cell carcinoma
RDW : Red cell distribution width
RS : Respiratory system
RSOV : Ruptured sinus of valsalva
RHD : Rheumatic heart disease
RLN : Recurrent laryngeal nerve
RR : Respiratory rate
RV : Right ventricle
RVH : Right ventricular hypertrophy
RVF : Right ventricular failure
REMS : Regional examination of musculoskeletal system
SAAG : Serum–ascites albumin gradient
SAH : Subarachnoid hemorrhage
SACD : Subacute combined degeneration of cord
SANRT : Sinoatrial node re-entrant tachycardia
SLRT : Straight leg raise test
SOFA : Sequential organ failure assessment
SIRS : Systemic inflammatory response syndrome
SSPE : Subacute sclerosing pan-encephalitis
SDAI : Simplified disease activity index
STMS : Short test of Mental status
SV : Stroke volume
SVT : Supraventricular tachycardia
SMA : Spinal muscular atrophy
SDH : Subdural haematoma
SCM : sternocleidomastoid
SLE : Systemic lupus erythematosus
STEMI : ST-Elevation myocardial infarction
SVC : Superior vena cava
SSR : Sympathetic skin response
SLICC : Systemic lupus international collaborating clinics
TAPVC : Total anomalous pulmonary venous connection
TIA : Transient ischemic attack
TB : Tuberculosis
TBI : Traumatic brain injury
TIN : Tubulointerstitial nephritis
TG : Triglycerides
TST : Thermoregulatory sweat test
TMJ : Temporomandibular joint
TSH : Thyroid stimulating hormone
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back and throwing his head forward goes through a sort of a tread-
mill dance, until the leaves are tightly compressed into the smallest
possible compass. More tea is then put in and pressed down in the
same manner until the chest is filled, when the leaden lid is put on
and soldered, the chest being nailed, clamped, matted and rattaned
later, numerous hands, men and women, being employed in its final
packing.
Before matting a Chinese character termed a “Chop-mark” is placed
on the side of each chest, ostensibly to denote the packer or picking,
but although the same “crop” or brand is received year after year
from the same shipper it does not necessarily follow that the grade
or quality will be the same or even equal to that of the preceding
ones.
The term “chop” in Chinese means contract, and does not, as is
claimed, refer to the crop or picking of any particular garden or
season. In trade it is applied to a quantity of tea frequently composed
of the product of different gardens, or piens (localities) and even
districts averaged or made uniform in the piens of the Twa-tu-tia by
the factors before forwarding to the shipping ports. When a sufficient
quantity of a certain specified grade has been secured from several
growers to make up a chop, it is carried to a warehouse in the
adjacent village, where it is all mixed together, averaged, refired and
packed for the foreign market. The quantity for a chop being selected
according to the quality of the leaf and the district producing it, and
considering how chops are made up—a few piculs from several
gardens, often widely apart, they are wonderfully uniform in grade.
Still, although year after year the same “chops” are received from the
same shippers, it does not follow that the chops of one year or
season will be as fine as those of the preceding or of equal quality. It
being by no means an unusual practice for the packers in the interior
to leave the chests unmarked until they reach the shipper, who,
knowing the chops must be in demand at that particular season in
the consuming countries, supplies them to order, or, at least, not to
use one of bad repute.
The average cost of medium to fine grades of tea is 40 taels (about
$20) per picul (133⅓ pounds) laid down at the port of shipment is as
follows at the present time: The refiring, packing, leading, chests,
matting and rattaning varying from $3 to $4 per picul more.
CHAPTER V.
C L A S S I F I C AT I O N
AND
D E S C R I P T I O N.
CHINA TEAS.
Tea and China are almost synonymous terms. It is indisputably the
“Land of tea.” Its cultivation forms the chief industry of that country,
and has been the largest contributor to the revenue of the
government for centuries, its export being the principal feature of all
her foreign dealings. The welfare of the inhabitants of her fairest
provinces depend on its production. It has been in universal use
among them from time immemorial, forming not only the regular
beverage of the people, but also administering to the luxury of the
epicure. They drink it at all times and under all circumstances from
early morning until late at night, in sickness or in health, working or
playing, traveling or resting, all business being transacted there
between two cups of tea. In brief, it is the natural beverage of the
country constituting what wine is to the French, beer to the German
and ale to the English, and but without which no Chinese family
could live or thrive.
Considering all this, the claim under the circumstances that any
other country is the “home of tea,” as is attempted at the present
time by some English writers, is about as futile and absurd as the
endeavor to substitute Americus for Columbus, or Bacon for
Shakespeare. And not only is China the original home of tea, but in
addition, China Tea is the only true tea, surpassing that of all other
countries in every property and quality constituting and distinguishing
tea, and possessing certain distinctive characteristics peculiar to and
contained in no other variety grown or known. Yet while grown to a
greater or less extent all over that vast empire, its cultivation for
commercial purposes appears to be chiefly confined to the eastern
provinces of Che-kiang, Kiang-see, Gan-hwuy and Fo-kien, some
little also being produced for export in the western province of Sze-
chuan.
Oolong Teas.
CONGOU TEAS.
KAISOW
OR
RED-LEAF CONGOUS
Saryune—Is the reddest of the Red-leaf teas, and while one of the
most serviceable of this variety, is not a fine sort by any means,
though often ripe and juicy. The liquor is almost invariably strong and
brisk, but burnt in flavor, the result of too high firing, and with the
exception of a few of the finer grades the leaf is rarely well curled,
being generally open, red and rough in appearance, the second and
third crops being usually very dusty or stemmy.
So-how—Is small and well made in leaf, dark, but rich in liquor, and
smooth and mellow in flavor for this variety of tea.
MONING
OR
BLACK-LEAF CONGOUS
Qui-fa—Is a “tarry” tea, allied to Amoy, but more evenly curled and
blacker in color. The liquor is strong and brisk, and not quite as rank
or bitter as that of the former. The infused leaf is very coarse and
irregular in form, often broken and very dark in color.
SOUCHONG TEAS
are among the finest and richest of the Black tea sorts, being known
to the Chinese as Saou-cheong, “Little,” or “scarce sort,” and are
limited in supply. They are chiefly prepared from the youngest leaves
of the earliest pickings, gathered only in the finest weather, and dried
in the shade to protect them from the direct rays of the sun. The dry