1.

Components of blood to which the drugs bind

2. Significance of HSA in drug binding
3. Apparent volume of distribution , Definition , formulae.
4. Markers for plasma volume,TBW ,ECF
5. Definitions of bioavailability,bioequivalence,therapeutic equivalence and pharmaceutical
equivalence.
6. Biotransformation – DEFINITION AND SIGNIFICANCE
7. Definition of clearance and extraction ratio
8. What is Michaelis Menten Kinetics ? e.g.s of physiological processes occurring by mixed order
kinetics
9. What is meant by AUC ? Methods used for determining area under the curve
10. Non- compartmental analysis
11. Diplacement interactions
12. Describe One compartment open model for IV bolus administration . Explain determination of
pharmacokinetic parameters for the same.
13. Measures of bioavailability (a) Plasma concentration data (b) Urinary excretion data
14. Absolute and relative bioavailability
15. Methods of bioavailability assessment .
16. Phase 1 & phase 2 pathways comparison
17. Enlist the Physiological barriers to drug distribution . Write short note on Blood brain barrier and
placental barrier
18. Name the renal and non renal routes of drug elimination
19. Describe the factors affecting renal excretion of drugs.