SOAl BLOCK 6 PDU 2008 Met RemidiaL yaH, 1. The number of systems in our body. a. 10 b. 11 c. 9 d. 12 2. Example of negative feedback.

a. stimulation of insulin secretion b. inhibition of glucogen secretion c. regulation f blood pressure d. regulation of blood clotting 3. Nervous tissue function.. a. Movement through contraction of cell b. Communication of information c. Storage of nutrients d. Protection 4. The regulation of body temperature is mainly done by a. Kidney b. The heart c. Skin d. Liver 5. Intracellular compartment is about% of body wight a. 10% b. 20% c. 40% d. 60% 6. Extracellular compartment is about..BW a. 10% b. 20% c. 40% d. 60% 7. Example of positive feedback . a. Stimulation of insulin secretion b. Inhibition of glucagons c. Regulation of blood pressure d. Regulation of blood clotting 8. An internal ..of cell is.. a. The extracellular fluid b. The intracellular fluid

c. The interstitial fluid d. The intravascular fluid 9. The control of center body of temperature looked in. a. The skin b. The blood vessels c. The brain d. The heart 10. The tissue which lines either the external as lateral surface of the body is. a. The skin b. The blood vessels c. The brain d. The heart 11. Some major risk factors of food borne illness are related to employees behavior and preparation practice in food service establishment. The principle known risk factors include.. a. b. c. over working raw shell eggs d. personal hygiene 14. Food service workers must pay close attention to personal hygiene. For instance workers who have a cold, the flu or another communicable illness, should inform their supervisor and not handle food. The following guidelines should be stressed to any workers dialing with food,.. a. wearing a hair restraint b. wearing apron c. keep finger nails clean unpolished and trimmed short d. all of the above 15. In processing or utensil-cleaning areas, there should be wash basin, a container of disinfectant. The minimum number of wash basin based on the number of employees are,. a. 1 for every 5 employees b. 2 for every 9 employees c. 3 for every 18 employees d. 4 for every 36 employees 15. separated toilet rooms with self dosing door, should be provided for men and women those working in food preparation area, the minimal number of toilet based on number of employes are. a. 1 untuk 3 org b. 2 untuk 9 org

c. 3 untuk 18 org d. 4 untuk 3 org 16. food processing plants must have adequate light to ensure that employes can perform their duties effectively. The minimum light requirements to carry out different operation in the plant are as follow, a. toilet rooms need 30 candles b. locker rooms need 40 candles c. storage rooms need 20 candles d. all of the above 17. Parameter to be measured to evaluate nutritional status of children under 5 aged suggested by who is as follow a. Sitting height b. Length of trunk c. Bicristal decimeter d. Biacromial diameter 18. Body length has to be measured as under 5 age children in developing countries have reach their linier measurement about a. 80 cm b. 82 cm c. 84 cm d. 86 cm 19. Measuring head circumference is a standard procedure at childhood department. The aim of this measurement is to find probability of pathological evidence. Head circumference is used as an indwx of chronic protein calorie malnutrition of the 3-aged children during,.. a. the first 2,0 years of life b. the first 2,5 years of life c. the first 3,0 years of life d. the first 3,5 years of life 20. BMR of a woman reach the lower point at the state of, a. a week before ovulation b. several hours before menstruation c. as the menstruation happened d. 1 day after the end of menstruation

23. the sources of water body loss should be monitorly close. The increase temperature from 38,3oC-39,4oC will increase the need of water a. 500 / 24 jam b. 800 / 24 jam c. 1100 / 24 jam d. 1300 / 24 jam 26. based on question 25, this kind of diet strictly give to patient who has criteria as follow, a. BMI 30 without b. BMI 29 without another risk c. BMI 28 without another risk d. BMI 27 without comorbid factor 27. Abang umur 10 thn membutuhkan obat segera untuk selamatkan diri, larutan yang available 100%, disuntikkan melalui,.a. intravena 29. Disturbance in membrane function and inability to reserve mithocondrial dysfunction is characteristic phenomena of, a. reversible injury b. apoptosis c. necrosis d. metaplasia 35. Hyperplasia is an increase in the number of cells in an organ or tissue. Which one is the pathologic hyperplasia a. Hyperplasia of the gland epithelium of the female breast at pregnancy b. Hyperplasia of the hepatocyte when the liver is partially resected c. Hyperplasia endometrium d. Hyperplasia that occurs in pregnant uterus 36. Metaplasia is a mechanism of defense in homeostasis microscopic squamous metaplasia usually occurs in the case,.. a. chronic dermatis b. esophagitis reflux c. chronic cervicitis d. acute bronchitis. 38. Enlargement of left ventricle in hypertension heart disease as a result to increase , this enlarged called.c. pathology hypertrofi

39. Trigliserid metabolism disorder and fat accumulation in hepatocyte, myocyte referred as a. Fatty change b. Hyperplasia change c. Xanthana d. Curhosis hepatic 40. The cellular response to injurious stimuli depends on the type of injury. It duration and severity if low doses of toxins for long time injuried the cell, the alteration of cell or tissue could be, a. cellular adaptation b. irreversible injury c. Reversible injury d. Cellular injury 43. Permanent cell injury resulted from ehronic inflammation can cause a. Metaplasia b. Neoplasia c. Atrophy d. Hipertrophy 44. Necrosis which occur denatured protein predominantly with preservation and framework,. e. Casceous necrosis f. Fat necrosis g. Coagulative necrosis h. Liquifective necrosis 45. necrosis that characteristically result of ischemic injury to the CNS is,. a. caseous necrosis b. liquifective necrosis c. sufurative necrosis d. gangrenous necrosis

46. Athenosklerosis is one of the end result of cell injury the proposed mechanism of injury in athenosklerosis is. a. chronic infection b. immunologic reaction c. Ischemia d. Hypercholesterolemia 47. Porphyrin is made of far pyrole rings. In hemoglobin, the type of porphyrin is called,

a. b. c. d.

uroporphyrin porphobilinogen coproporphyrin protoporphyrin

48. Porphyrin may accumulate in the skin and explosive to UV light makes cutaneous eruption. Which porphyria is not associated with photo sensitivity a. photoporphyria b. PCT c. AIP d. HC Cherediter corproporphyria 49. Glucagon is the interceluler communication which include in the type of a. autocrine b. exocrine c. paracrine d. endocrine 50. Activated G protein interects with efector protein to cuter their activities this proces of communication occur in a. Extraceluler compartement b. Intraceluler compartement c. Intranuclear compartement d. Intratisial compartement 51. Short term regulator that secreted from .cells when stomach empty steps within an hour of eaten a. peptide YY b. ghrelin c. cholecysto kinine d. leptin 52. Nung cilik was climbed and got loss for 3 days, sweated and diarrhea a. hyporatremia b. hipovolemia c. hipokalemia d. hiperkalemia 54. Digoxin is a cardiac glycoside that is often used in the treatment of heart failure. Digoxin increase cardius contractility by a. Actrirating L-type Ca 2+ channels b. Inhibiting myocardial Na + / Ca 2+ ATP ase c. Inhibiting myocardial Na + / K + ATP ase d. Inhibiting cardiac thosphodi esterase

57. thiazide diuretics, B-adrenoeceptors antagonist, calcium channel blockers and angiotensin converting enzyme inhibitors are four groves of drugs that have been considered among the first line. Drugs for the treatment of hypertensive patients. Select one of the listed drugs below that belongs to calcium channel blockers,.. a. chlorthalidon b. verafamil c. atenolol d. enalapril 58. Digoxin is the drug of choice in the treatment of a patient with heart failure associated with established rapid atrial filbrillation. Digoxin decreases the heart rate by e. centrally enhacins the activity the activity of N. Vagus f. Inhibitins the atrio-ventricular condution g. Increasins the cardiac contractrility h. Antagonizins the action of noradreration 59. loop diuretics (e.g. furosemide) and ACET (e.g. captopril) are the first line drugs in the treatment og congestive heart failure. Flurosemide exerts its therapeutic effect by,. a. Increasing renal diuresin therefore decreasing cardiac preload b. Inhibit release of aldosteron from adrenal cortex c. Producing vasodilatation d. Decreasing simpatetic nervous sistem

60. Some hypertensive patients can not tolerate taking an ACEI (e.g. captopril) for their treatment, because of the sie effect of irritating dry chough produced by ACEIs. In this case losortan can be given as a substitute, Losortan reduces this arterial blood pressure by,. a. binding to alpha-adrenoceptors b. blocking the action of noradrenalin by binding to 1 adrenoreceptors c. blocking the action of angiotensin II, by binding to AT receptor d. inhibiting the action of aldosteron. 62. Propanolol is contraindicated in hypotensive patients who also have asthma bronchiole. This is true because,. a. propanolol causes bronchospasm b. propanolol is a cardioselective blocker c. propanolol also blocks 2-adrenoceptors and therefore inhibits bronhodilatis effect of a 2 agonists resulting in severe asthma attacks.

d. propanolol tends to cause hypotension and asthmatic patients. 64. Most drugs move from one to other compartment in body through mechanism call passiff the rate of diffusion is determined by its.. a. potency b. affinity to a receptor c. lipid solubility d. dose 65. One of the drug tarsets of action is an ion channel are example of drug that produced its effect by inhibiting,the opening of Ca channel is, a. Bisoprol b. Nifedine c. Captopril d. Hydrochloratiazide 68. Dari molekul kompleks menjadi molekul sederhana a. Katabolisme b. Hidrolisis c. Anabolisme d. Metabolisme 72. after biotransformasi, a drug will become a new compound called a metabolite sometimes a pharmalogical in active drug becomea pharmaco,..after under going metabolis is,. a. prodrug b. parent drug c. free drug d. bound drug

74. cairan didalam sel disebut,..Intraselular fluid 75. Total body wafer consthutes a. 30 % of BW b. 40 % of BW c. 50 % of BW d. 60 % of BW 76. If one (1) gram molecular weight of non ionized substance is dissolved in 1 L of solution the concentration will be a. 1 osmolal b. 1 osmolar c. 1 mili equivalent d. 1 molar

77. The principal of ion intracellular..(K+) 78. Third space losses can be found in..(burn) 79. plasma volume can be measured either by.. a. inulin b. deuterium oxide c. radioactive albumin d. evans blue

80. hipovolemik can be recognized by a. naiknya tekanan darah b. turunnya hart rate c. absence of perfusion d. normal respiration rate 81. Ringers lactate contains all of the following ions,.. a. bicarbonate b. phosphate c. sodium d. cellular alteration 82. Aldosteron, a mineral corticoid is the hormone responsible for the precise control of,. a. K+ excretion b. Cl- excretion c. Na+ excretion d. Urine excretion 84. In glikolisis there are irreversible enzyme include.. a. Hexokinase b. Glukosa 6 Phospate Dehidrogenase c. Aldolase d. Gliseraldehide 3 Phosphate 85. In one cycle of Crebs cycle it will produce,..ATP a. 2 b. 8 c. 10 d. 12

92. Kelebihan glukosa disimpan dalam bentuk,..85% dihati dan sisanya di otot.

a. glikogen b. fat c. laktat d. protein 93. cell can not uptake glucose, so concentrations remain very high in blood, causing glucose to end up in urine.. a. diabetes insipidus b. diabetes mellitus c. lactic acidosis d. keto acidosis 94. Food that contain complete amino acid is.. a. tofu b. tempe c. egg d. nuts 97. Proses pemanfaatan / perubahan energi melalui panas / kerja sesuai dengan huku, kekekalan energi, a. I b. II c. III d. IV 98. Jika puasa lebih dari 48 jam (2x24 jam) proses yang terjadi adalah. a. Glikolisis b. Glikogonolisis c. Gikogenesis d. Glukoneogenesis 100. Enzim yang berikatan dengan thiamin, a.hexokinase b. glukosa 6 fosfat c.glukosa 6 fosfat dehidrogenase d. .. 101. Kerja enzim sebagai biokatalisator ? a. mempercepat energi aktivasi b. menurunkan energi aktivasi c. menaikan Km d. Menurunkan Vmax 102. Holoenzim adalah bentuk enzim yang terdiri dari . a. meliputi koenzim

b. meliputi vitamin c. meliputi apoenzim + koenzim d. meliputi koenzim + vitamin 104. Enzim yang menurut klasifikasi berfungsi menggabungkan molekul adalah b. Liase c. Ligase d. Okside-reduktase e. Transferase 106. Suatu enzim secara kinetic bila harga km 2x harga substrat maka kecepatan reaksi enzim tersebut adalah sebesar,.. a. =V max b. V max c. 1/3 V max d. V max 108. Suatu inhibitor ang mengubah parameter enzim Km dan Vmax maka inhibitor tersebut berjenis,.. a. kompotitif b. Nonkompetitif c. Unkompetitif d. Irreversible 109. The product of enzymatic reaction could influence conformation of active side of an enzyme. This inhibitor effect is called,.. a. competitive b. reversible c. irreversible d. feedback 111. cairan asam lambung 100 ml pHCl 2,25 ditambah 100 ml. pH ??? a. 2,25 b. 2,55 c. 3,55 d. 4,50 112. Seseorang yang muntah berat, HCl banyak keluar, pH turun kemungkinan terjadi, a. alkalosis respiratorik b. alkalosis metabolic c. Asidosis respiratorik d. Asidosis metabolic 113. 10 ml CH3COOH 0,1 N + 15 ml NaOH 0,2 N a. buffer

b. asam lemah c. hidrolisis d. rumus basa kuat 117. Apabila terjadi gangguan pengeluaran CO2 dari tubuh maka terjadi, a. alkalosis respiratorik b. alkalosis metabolic c. asidosis respiratorik d. asidosis metabolic 118. b. c. d. e. Larutan buffer bila diencerkan, maka PH tetap sebab ada kapasitas buffer ada sisa asam/basa lemahnya CH+J merupakan perbandingan garam tersisa asam/basa lemahnya Ada pKa nya dan pKb nya

119. Kapasitas buffer adalah b. Kemampuan buffer mempertahankan PH bila ditambah asam/basa c. Kemampuan buffer mempertahankan PH bila diencerkan d. Kemampuan buffer mempertahankan PH ada pKa=7,4 e. Kemampuan buffer mempertahankan PH saat ada perubahan 122. Waktu pemberian obat tidur yang tepat,. a. ante coenam b. durante coenam c. post coenam d. ante nocterm

123. seorang ibu mempunyai penyakit asma. Obat yang tepat, aman dan absorbsi cepat dalam bentuk,. a. kapsul b. supositoria c. aerosol d. injeksi 124. Adam 2 tahun, menderita keringat malam dan diberi obat dalam bentk serbuk tabur. Serbuk manakah yang cocok??? a. pulvis adspersorius b. pulvis aerophorus c. pulvis dentrificus d. pulvis stomachicus

125. NonaA, mendapat gangguan absorpsi pada saluran pencernaannya. Kemudian diberikan obat untuk ,membantu mempercepat absorbsi dalam bentuk sediaan cair. Bentuk sediaan yang diberikan adalah a. emulsi b. saturation c. solution d. suspensi 126. Tuan X, menderita sakit yang membutuhkan obat dalam prioode tertentu, di mana obat akan melepaskan bahan berkhasiat secara lambat dan memberi cadangan obat secara terus menerus dalam waktu yang oanjang. Bentuk sediaan tablet yang paling tepat untuk tuan X adalah.. a. Multiple compressed tablets b. Enteric coated tablets c. Sugar coated tablets d. Sustained release tablets 127. Abang, anak laki-laki umur 10 tahun membutuhkan obat segera untuk menyelamatkan jiwanya. Obat yang diberikan dalam bentuk injeksi dengan pelarut air dan memberikan bioavailabilitas 100%. Cara pemberian manakah yang paling tepat ? a. subcutan b. intramuscular c. intravena d. intrathecal

127. Necrosis is pathologic can see by light microscope of arteri wall malignant hypertensi,. a. fat necrosis b. fibrin necrosis c. caseous necrosis d. coagulative necrosis 128. Tuan Z, diberi obat tablet bukal dengan cara menyisipkan diantara pipi dan gusi dalam rongga mulut. Tujuan pemberian dengan cara diatas adalah agar absorbsi obat.. a. dipercepat b. tetap c. lambat d. ditunda

129. Nyonya Y, memerlukan obat untuk menyembuhkan luka yang ada disekitar lengannya. Obat yang diberikan bentuk sediaan setengah padat yang mudah dicuci dengan air. Bentuk sediaan setengah padat yang tepat adalah. a. linimentum b. Cream c. pasta d. Unguentum

131. Perubahan internal berupa respon terhadap kondisi-kondisi mendadak seperti luka, stress, kurang makan dan air, yang dulakukan bedasarkan urutan : b. chromophobic cellcorticotropinACTHcortex adrenalhormon corticosteroid c. pars distalis hipofisesel basofilikTHSkelenjar tiroidtiroxin d. preganglionic symphatetic nervesmedula adrenalisadrenalin dan norepinefrin e. pars distalis hipofisesel asidofilikTHSkelenjar tiroidtiroxin

132. kelenjar sudirifera merupakan,. a. alveolus simplek b. kelenjar tubuler simplek bercabang c.kelenjar tubuler simplek bergelung d. kelenjar alveolus kompleks 136. Johni mengalami apa Jawaban : Hipovolemi dan hypoxia 137. Skenario Kompensasi tubuh terhadap stress e. Lemas f. g. Tekanan darah turun h. Denyut jantung tururn 139. Sistem saraf tersebut memberikan perintah melalui sinyal simpatis yang dikirim melalui b. Nervus Vagus c. Korteks serebric d. Medula oblongata e. Medula spenalis

143.

Pada saat itu sebenarnya sistem endokin Joni berusia berkomposisi dengan mengeluarkan hormone berikut b. Insulin c. Testostoren d. Kortisol e. Asetilkolin

145. bila terap cairan berhasil pada joni maka joni akan mengalami fase recoveri yaitu, a. resintesis protein b. rekonstruksi struktur sel c. replesi energi d. normalitas metabolisme Soal untuk 146-150 Karena lapar, Boni sanggup menyantap 1 porsi penuh nasi bungkus dengan lauk tahu goring dan kecap. Setelah kenyang Boni tertidur pulas. Baru 15 menit tidur, Boni dikejutkan dengan teriakan Maliiingg !!!! yang berasal dari sebelah kamar kosnya. Dengan sigap Joni bangkit dari kasur dan langsung berlari kencang mengejar maling, kejar-kejaran berlangsung selama 10 menit, setelah akhirnya Boni terduduk lemas dengan nyeri ulu hati, kaki pegal dan nafas terlihat sesak. 147. Dalam peristiwa tersebut sistem digestif Boni bekerja dibantu dengan cairan enzim, proses ini disebut dengan,. a. hidrolisis b. Oksidasi c. Sintesis d. Mixing 150. b. c. d. e. Saat tidur pulas, sebagian energi yang dipakai bersumber dari Konversi fosfokreatin Glikolisis aneorobik Fosfosilasi oksidatif Aerobic glikolisis

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