Q.

1 DrIvIng Iorce In drug movement In

aqueous dIIIusIon modeI:
(A} aciivc iransori-- cncrgy rcquiring
(D} faciliiaicd iransori
(C} drug conccniraiion gradicni (D} nonc
Q.2 RenaI excretIon Iactor most IIkeIy to be
sensItIve to drug IonIzatIon state:
(A} glomcrular filiraiion (D} assivc iulular
rcalsoriion (C} loiI (D} nonc
Q.3 Drugs wbIcb exbIbItsa bIgb bepatIc"
IIrst-pass" eIIect:
(A} lidocainc (D} roranolol (C} loiI (D}
nciiIcr
Q.4 PermanentIy cbarged amIne Iorm:
(A} rimary aminc (D} sccondary aminc
(C} icriiary aminc (D} quaicrnary aminc
Q.S For bIgb extractIon-ratIo drugs,
patIent to patIent bIoavaIIabIIIty may vary
due to dIIIerences In:
(A} Icaiic funciion (D} llood flow (C} iIc
rcscncc of Icaiic discasc (D} all
Q.6 Factors assocIated wItb drug
absorptIon tbat can resuIt In IncompIete
absorptIon
(A} drug mcialolism ly gasiroinicsiinal flora
(D} drug IydroIiliciiy (oosiic of
lioIiliciiy}
(C} rcscncc of food in iIc CI iraci (D} all
Q.? Drug cbaracterIstIcs contrIbutIng
to reIIabIe transdermaI drug absorptIon:
(A} molccular wcigIi morc iIan 1000
(D} drug causc Iisiaminc rclcasc
(C} iIc daily drug rcquircmcni is lcss iIan 10
mg (D} nonc
Q.S ConcernIng parenteraI drug
admInIstratIon:
(A} lcss rcdiciallc comarcd io oral
adminisiraiion rouic
(D} noi accciallc for unconscious aiicnis
(C} raic of drug sysicmic alsoriion
inscnsiiivc io drug soluliliiy in inicrsiiiial
fluid
(D} raic of sysicmic drug alsoriion following
arcnicral adminisiraiion dccnds on
alsorling caillary mcmlranc surfacc arca
Q.9 PbarmacokInetIc advantages
assocIated wItb transdermaI drug deIIvery:
(A} rclaiivcly consiani, susiaincd iIcracuiic
lasma drug conccniraiions
(D} commonly low sidc-cffcci incidcncc (C}
good aiicni comliancc
Q.10 Drugs Ior wbIcb "IIrst-pass"
puImonary uialc may ccccd 65% of
injccicd dosc. (A} fcnianyl (D}
alfcnianil (C} sufcnianil (D} all
Q.11 Roots oI admInIstratIon tbat not
avoId "IIrst-pass" bepatIc eIIects:
(A} sullingual (D} oral (C} iransdcrmal
(D} lowcr rccial suosiiorics
Q.12 Drugs Ieast IIkeIy to penetrate across
membranes:
(A} roicin-lound drugs (D} cIargcd drugs
(C} ncuiral drugs (D} nonc
Q.13 wbIcb oI tbe IoIIowIng Is a saturabIe
transport mecbanIsm
(A} assivc diffusion (D} aciivc diffusion
(C} orc iransori (D} nonc
Q.14 ConcernIng "IIrst pass" eIImInatIon:
(A} drug is firsi iransoricd across iIc gui wall
inio iIc orial circulaiion
(D} drug mcialolism may occur in iIc
inicsiinal wall
(C} somciimcs cicnsivc drug mcialolism may
occur in iIc livcr
(D} iIc livcr may ccrcic drug inio iIc lilc
Q.1S Factors wbIcb eIIect a drug's voIume
oI dIstrIbutIon:
(A} aiicni's gcndcr (D} aiicn'is agc
(C} rcscncc of discasc (D} all
Q.16 Two most Important sItes Ior drug
eIImInatIon:
(A} ulmonary and livcr (D} livcr and CIT
(C} lidncy and livcr (D} slin and livcr
Q.1? ConcernIng transIer oI basIc drugs
sucb as nonIonIzed IocaI anestbetIcs Irom
motber to Ietus:
(A} fcial H is IigIcr iIan maicrnal H
(D} in fcial disircss allalosis coniriluics io
local ancsiIciic accumulaiion
(C} conccrning maicrnal llood. fcial llood --
gradicni is mainiaincd for coniinual local
ancsiIciic iransfcr from maicrnal circulaiion
io fcial circulaiion
(D} all
Q.1S CbaracterIstIcs oI renaI
drug excretIon:
(A} ncarly all drugs arc filicrcd ai iIc
glomcrulus (D} drugs wIicI arc wcal acids arc
ccrcicd fasicr in acidic urinary H
(C} drugs wIicI arc wcal lasc is our ccrcicd
fasicr in allalinc urinary H (D} Nonc
Q.19 Cytocbrome P4S0 InductIon
(Increased, amount oI P4S0 enzyme
proteIn) Is oIten assocIated wItb:
(A} incrcascd cnzymc syniIcsis raics
(D} rcduccd cnzymc dcgradaiion raics
(C} loiI (D} nciiIcr
Q.20 MIcrosomaI drug metaboIIzIng
enzymes are typIcaIIy assocIated wItb:
(A} rougI cndolasmic rciiculum
(D} smooiI cndolasmic rciiculum
(C} loiI (d} nonc
Q.21 CbaracterIstIcs oI drug conjugates
(IoIIowIng conjugatIon reactIons)
(A} morc olar
(D} morc rcadily ccrcicd
(C} iyically morc Iarmacologically aciivc
(D} loiI a and l
Q.22 A drug moIecuIe cbemIcaIIy modIIIed
Ior ImprovIng absorptIon and tbat IIberates
actIve drug aIter metaboIIsm In vIvo Is
known as
(a} Prodrug (l} Aciivc drug
(c} Aciivc mcialoliic (d} Long aciing drugs
Q.23 AbsorptIon oI drug tbrougb skIn Is
dependent on
(a} liid soluliliiy (l} Proicin soluliliiy
(c} Waicr soluliliiy (d} Clycoroicin soluliliiy
Q.24 Tbe passage oI drugs Irom route oI
admInIstratIon Into systemIc cIrcuIatIon
Is known as :
(a} Alsoriion (l} Adsoriion
(c} Disiriluiion (d} Diffusion
Q.24 WbIcb oI tbe IoIIowIng route Is not
suItabIe Ior admInIstratIon oI oIIy
soIutIons and suspensIons?
(a} I.V (l} I.M (c} S.C (d} Oral
Q.2S Tbe cbemIcaI cbange oI drug moIecuIe
tbat occur In tbe body by varIous
bIocbemIcaI reactIons Is known as.
(a} Dioiransformaiion (l} Diocquivalcncc
(c} PIarmalodynamics (d} Dio-availaliliiy
Q.26 VoIume oI dIstrIbutIon oI a drug Is tbe
ratIo oI amount oI drug In tbe body to tbe
(a} Dlood drug conccniraiion (l} Plasma drug
ccniraiion
(c} Urinc drug conccniraiion (d} All iIc alovc
Q.26 A seIectIve and energy dependent
transport oI drug moIecuIe tbrougb
tbe membrane agaInst tbe
concentratIon gradIent Is caIIed as
(a} Passivc iransori (l} Aciivc iransori
(c} Faciliiaicd diffusion (d} Fcvcrsc osmosis
Q.2? Tbe transport oI drug tbrougb a
membrane by passIve dIIIusIon Is
dIrectIy proportIonaI to tbe
(a} Conccniraiion gradicni
(l} Conccniraiion of clccirolyics
(c} P
H
of llood (d} Volumc of llood
Q.2S ProteIn bIndIng oI drugs In tbe body
Isused In
(a} Susiaincd drug aciion
(l} Tcmorary drug aciion
(C} PcriIcral drug aciion
(d} Conirol rclcasc drug aciion

Q.29 In order to produce cbaracterIstIc
pbarmacoIogIcaI actIon a drug must
aIways
(a} FcacI IigI llood lcvcls
(l} Alsorlcd from CIT rcadily
(C} AcIicvc adcquaic conccniraiion ai iIc siic
of aciion
(d} Ecrcic uncIangcd in urinc
Q.30 InIusIon means
(a} Iniravcnous adminisiraiion of largcr
amouni of fluid 1 io 2 liircs
(l} Iniramuscular adminisiraiion of largcr
amouni of fluid 1 io 2 liircs
(c} Inira dcrmal adminisiraiion of largcr
amouni of fluid 1 io 2 liircs
(d} Inira aricrial adminisiraiion of largcr
amouni of fluid 1 io 2 liicrs
Q.31 WbIcb oI tbe IoIIowIng enzyme
responsIbIe Ior tbe pbase 1 reactIon
(a} csicrasc (l} aminoacid iransfcrasc
(c} sulfolinasc(d} glucournyl iransfcrasc
Q.32 CYP -4S0 enzyme wbIcb cataIyze tbe
oxIdatIon reactIon maInIy Iound In
(a} miiocIondria of livcr ccll (l}miiocIondria of
lidncy ccll (c} surfacc of rougI
cndolasmic rciuculaum(d} nonc
Q.33 PbenytoIn Is act ac as CYP-4S0
EN2YME
(a} inIiliior (l} induccr (c} sulsiraic (d} loiI
a and l