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One Compartment Open Model For Extravascular Administration

The document discusses the pharmacokinetics of drug absorption and elimination following extravascular administration. It distinguishes between zero-order and first-order absorption characteristics, highlighting their mathematical descriptions and dependencies on the amount remaining to be absorbed. The absorption and elimination phases are illustrated through various plots and equations.

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mssakthivelmurugan33
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878 views2 pages

One Compartment Open Model For Extravascular Administration

The document discusses the pharmacokinetics of drug absorption and elimination following extravascular administration. It distinguishes between zero-order and first-order absorption characteristics, highlighting their mathematical descriptions and dependencies on the amount remaining to be absorbed. The absorption and elimination phases are illustrated through various plots and equations.

Uploaded by

mssakthivelmurugan33
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

&robhomacauka Phomacokinub'es BP 604T

Unit-3 Uoit L-32


Onu Comportmunt Ofen Modul. Dr. Parjanya Shukla
Exhovasular Adminishahon
Dr. M. P. Singh Casses
* Wken o drug is administend by extavanlar toutu
(29 ora, i.m., uchal ete-)

absorf hon is o puaqaikate for ih Haapauhe achviky


* h sate of absophion may be descnibd mahmeheally
Zro-ordr or fiat ordor þrous

Zaro-order absorpHon firat- ordT abAorp Hon


charadnged by o Constant choracleriged by dacbinu in
aatu abrorpion tk xata with ARA
i indeendunt o Anmounl absopHon uas debends on ARA.
Romaining to bu absorkud (ARA)
dx/d = Rae o abovpBon -- Rat
Rate o eliminahonBy-Dr.
dx dXev d XE
dt dt Mahundra

kqulor (orlesion) Plot Semidog plot Pratap

ZAro-ord1y ZTO Ordor


Sing

fst
ordr 0rder

Timu
Thi absorþlion and elimi nakon phasa d thu þlasma
Conuntraon tmu Dr. Parjanya Shukla
Dr. M. P. Singh Claes
obtained altey exravascular adminiabahon o asingu dosA d a drug

Cmox
lonunhabon Absorption Hahu = Eliminahion ate
Absorphon
bhase

Post abaoyphon þhasL


Drug
-
Plasma

eliminahon phasa

By- Dr. Mahen dro Pratap Singh

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