Scribd
Upload
12 views5 pages

Inflammatory Markers

The document outlines various proteins and their changes in inflammation, highlighting their functions and clinical relevance. Key markers such as C-Reactive Protein and Serum Amyloid A increase during inflammation, while Albumin and Transferrin decrease. It also categorizes markers into acute and chronic types, detailing their significance in diagnosing infections and chronic diseases.

Uploaded by

imarairshad11
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
12 views5 pages

Inflammatory Markers

The document outlines various proteins and their changes in inflammation, highlighting their functions and clinical relevance. Key markers such as C-Reactive Protein and Serum Amyloid A increase during inflammation, while Albumin and Transferrin decrease. It also categorizes markers into acute and chronic types, detailing their significance in diagnosing infections and chronic diseases.

Uploaded by

imarairshad11
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Protein Change in Inflammation Function / Relevance

C-Reactive Protein (CRP) Increase Sensitive marker, rises


quickly in infection
Serum Amyloid A (SAA) Increase Elevated in acute and
chronic inflammation
Haptoglobin Increase Binds free hemoglobin,
inflammation marker
Ceruloplasmin Increase Antioxidant, rises in
inflammation and
pregnancy
α2-Macroglobulin Increase Protease inhibitor, rises in
nephrotic syndrome
α1-Acid Glycoprotein (AGP) Increase Seen in chronic disease
and malignancy
Fibrinogen Increase Coagulation factor,
increases ESR
Complement (C3, C4) Variable (↑ or ↓) ↑ in acute, ↓ in
autoimmune diseases like
SLE
Albumin Decrease Negative APP; reduced in
inflammation and
malnutrition
Transferrin Decrease Iron-binding; lowered to
limit pathogen access to
iron
Transthyretin (Prealbumin) Decrease Falls rapidly in acute illness
Retinol-binding protein Decrease Reduced in inflammation;
transport protein for
vitamin A

Marker Type Clinical Significance


CRP Acute & Chronic Rises rapidly in infection;
persists in chronic
inflammation
Procalcitonin Acute Specific for bacterial
infections and sepsis
Serum Amyloid A Acute Rises rapidly in
inflammation
IL-6, TNF-α, IL-1 Acute Pro-inflammatory
cytokines, trigger acute-
phase response
Ferritin Acute Acute-phase reactant; also
elevated in chronic
inflammation
WBC Count Acute Elevated in most bacterial
infections
ESR Chronic Slow to rise and fall;
reflects long-term
inflammation
Fibrinogen Chronic Sustained elevation during
inflammation
α1-Acid Glycoprotein Chronic Seen in chronic
inflammation and
malignancy
Complement (C3, C4) Chronic Decreased in autoimmune
diseases like SLE
Immunoglobulins (IgG) Chronic Elevated in chronic
infections and autoimmune
diseases

You might also like