Category Neuroleptics

Drugs that cause weight gain Thiorizadine, olenzepinequetiapine, resperidone

clozapine, ziprasodone Antidepressants Tricyclics Monoamine inhibitors Selective seronim reuptake Valproate, carbamazepine inhibitors Anti-convulsants Anti-diabetic drugs Anti-serotonim Antihistamines Beta-adrenergic blockers Steroid hormones Gabapentin Insulin, sulfonylireas thiazolidinediones Pizotifen Cyproheptidine Propanol, terazosin Contraseptives, steroids glucocorticoids, progestational Amitriptyline, nortriptyline Impramine, mitrazapine oxidase Paroxetine

Resiko morbiditas Lingkar perut Klasifikasi IMT (kg/m) < 90 cm (laki- 90 cm (lakilaki) dan < 80 laki) dan 80 cm (perempuan) Underweight < 18.5 Rendah resiko 18.5 22.9 23 23 24.9 25 29.9 30 Meningkat Sedang Berat Sedang Berat Sangat berat cm (perempuan)

(tapi Rata-rata klinis

lain meningkat) Normal Overweight Beresiko Obes I Obes II Rata-rata Meningkat

Kriteria

Kriteria ATP III revisi

International Federation

Diabetes

Lingkar perut Perempuan Laki-laki Kolesterol HDL Perempuan Laki-laki Glukosa Tekanan darah < 50 mg/dL < 40 mg/dL 100 125 mg/dL 130/85 mmHg < 50 mg/dL < 40 mg/dL 100 125 mg/dL 130/85 mmHg > 88 cm > 102 cm > 90 cm > 94 cm

Zat gizi Kalori Lemak total Asam lemak jenuh Asam lemak tak jenuh tunggal Asam lemak tak jenuh ganda Kolesterol Protein Karbohidrat NaCl Kalsium Serat

Asupan yang dianjurkan Dikurangi 500-1000 kkal/hari dari kebutuhan 20-3-% dari total kalori 8-10% dari total kalori Sampai 15% dari total kalori Sampai 15% dari total kalori <300 mg/hari 15-25% dari toal kalori 55-60% dari total kalori Tidak lebih dari 100 mmol/hari Setara 2,4 g atau 6 g NaCl 1000-1500 mg/hari 20-30 /hari

Light < 3 METs Walking slowly around home, store or office Household & occupation Sitting using computer; work at desk using light hand tools Standing performing light work such as making bed, washing dishes, ironing, preparing food Leisure time & sports Billiards Fishing sitting Playing most musical instruments

Moderate 3 6 METs Brisk walking Household & occupation Cleaning heavy; washing windows, car Sweeping floors or carpet, vacuuming, mopping

Vigorous > 6 METs Hiking at steep grades Jogging Household & occupation Shovelling sand, coal, etc Carrying heavy loads such as bricks

Leisure time & sports Badminton recreational Bicycling on flat : light effort Dancing ballroom Golf Swimming Tennis doubles

Leisure time & sports Basketball game Fast bicycling Soccer Tennis singles

Agent

Mechanism of action

Dosage

DEA Schedult +

Potential drug interaction

Benzphetamine (Didrex)

Noradrenergic

25 to 50 mg one to three times per day

III

MAOIs,

guanethidine,

CNS

stimulants, alcohol, sibutramine, tricyclic antidepressants

Phendimetrazine (Bontril)

Noradrenergic

17.5 to 70 mg two to three times per day or 105 mg sustained release per day.

III

Same as above

Phentermine (Adipex-P) Phentermine resin (Lonamin) Diethylproprion (Tenuate)

Noradrenergic

18.75 to 37.5 mg per day

IV

Same as above

Noradrenergic

15 to 30 mg per day

IV

Same as above

Noradrenergic

25 mg three times per day or 75 mg sustained release per day

IV

Same as above

Sibutramine (Meridia)

Mixed Noradrenergic Serotonergic

5 to 15 mg per day

IV

SSRIs, MAOIs, centrally active anorexiants, dihydrierginatamine, dextromethorphan, meperidine, sumatriptan,

pentazocine, fentanyul, lithium, tryptophan Orlistat (Xenical) Lipase inhibitor 120 mg three times per day with or within one hour after fat containing meals, plus a daily Not scheduled Cyclosporine

multivitamin