Biomedical Signal Analysis (3rd Edition) Rangayyan PDF
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Biomedical Signal Analysis
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IEEE Press
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Biomedical Signal Analysis
Third Edition
Rangaraj M. Rangayyan
University of Calgary
Calgary, AB
Canada
Sridhar Krishnan
Toronto Metropolitan University
Toronto, ON
Canada
IEEE Press Series in Biomedical
Engineering
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Copyright © 2024 by The Institute of Electrical and Electronics Engineers, Inc.
All rights reserved.
Published by John Wiley & Sons, Inc., Hoboken, New Jersey. Published
simultaneously in Canada.
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Library of Congress Cataloging-in-Publication Data Applied for:
Hardback: 9781119825852
Cover Design: Wiley Cover
Image: © Sri Krishnan
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DEDICATION
Mátr dévô bhava
Pitr dévô bhava
Áchárya dévô bhava
Look upon your mother as your God
Look upon your father as your God
Look upon your teacher as your God
— from the sacred Vedic hymns of the Taittireeya Upanishad of India.
This book is dedicated to the fond memory of
my mother Srimati Padma Srinivasan Rangayyan
and my father Sri Srinivasan Mandayam Rangayyan,
and to all of my teachers,
in particular, Professor Ivaturi Surya Narayana Murthy.
Rangaraj
This book is dedicated to
my parents, mentors, students,
and my wife Mahitha,
and to our children Sibi and Sarvi.
Sridhar
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CONTENTS
About the Authors xvi
Foreword by Prof. Willis J. Tompkins xviii
Foreword by Prof. Alan V. Oppenheim xix
Preface xxii
Acknowledgments xxviii
Symbols and Abbreviations xxxi
About the Companion Website xxxix
1 Introduction to Biomedical Signals 1
1.1 The Nature of Biomedical Signals 1
1.2 Examples of Biomedical Signals 4
1.2.1 The action potential of a cardiac myocyte 5
1.2.2 The action potential of a neuron 9
1.2.3 The electroneurogram (ENG) 10
1.2.4 The electromyogram (EMG) 12
1.2.5 The electrocardiogram (ECG) 20
1.2.6 The electroencephalogram (EEG) 29
1.2.7 Event-related potentials (ERPs) 35
1.2.8 The electrogastrogram (EGG) 36
1.2.9 The phonocardiogram (PCG) 37
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viii CONTENTS
1.2.10 The carotid pulse 40
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1.2.11 The photoplethysmogram (PPG) 41
1.2.12 Signals from catheter-tip sensors 43
1.2.13 The speech signal 44
1.2.14 The vibroarthrogram (VAG) 48
1.2.15 The vibromyogram (VMG) 52
1.2.16 Otoacoustic emission (OAE) signals 52
1.2.17 Bioacoustic signals 52
1.3 Objectives of Biomedical Signal Analysis 52
1.4 Challenges in Biomedical Signal Analysis 55
1.5 Why Use Computer-aided Monitoring and Diagnosis? 58
1.6 Remarks 60
1.7 Study Questions and Problems 60
1.8 Laboratory Exercises and Projects 62
References 63
2 Analysis of Concurrent, Coupled, and Correlated Processes 71
2.1 Problem Statement 71
2.2 Illustration of the Problem with Case Studies 72
2.2.1 The ECG and the PCG 72
2.2.2 The PCG and the carotid pulse 73
2.2.3 The ECG and the atrial electrogram 73
2.2.4 Cardiorespiratory interaction 75
2.2.5 Heart-rate variability 75
2.2.6 The EMG and VMG 77
2.2.7 The knee-joint and muscle-vibration signals 77
2.3 Application: Segmentation of the PCG 78
2.4 Application: Diagnosis and Monitoring of Sleep Apnea 79
2.4.1 Monitoring of sleep apnea by polysomnography 80
2.4.2 Home monitoring of sleep apnea 80
2.4.3 Multivariate and multiorgan analysis 82
2.5 Remarks 85
2.6 Study Questions and Problems 85
2.7 Laboratory Exercises and Projects 86
References 86
3 Filtering for Removal of Artifacts 91
3.1 Problem Statement 91
3.2 Random, Structured, and Physiological Noise 92
3.2.1 Random noise 92
3.2.2 Structured noise 98
3.2.3 Physiological interference 98
3.2.4 Stationary, nonstationary, and cyclostationary processes 99
