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  • Daftar Is1

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    Dwi Fitri Ramadhani Baso
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    DAFTAR IS1

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    19 views14 pages

    Daftar Is1

    Uploaded by

    Dwi Fitri Ramadhani Baso
    vb

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 14

    This is the microscopic appearance of an acute renal infarct.

    At the far right is normal kidney,


    then to the left of that hyperemic kidney that is dying, then to the left of that pale pink infarcted
    kidney in which both tubules and glomeruli are dead.
    This is an ascending bacterial infection leading to acute pyelonephritis. Numerous PMN's are
    seen filling renal tubules across the center and right of this picture.
    The tubular vacuolization and dilation here is a result of ethylene glycol poisoning. This is
    representative of acute tubular necrosis (ATN), which has many causes. ATN resulting from
    toxins usually has diffuse tubular involvement, whereas ATN resulting from ischemia (as in
    profound hypotension from cardiac failure) has patchy tubular involvement.
    Here is a vasculitis of a renal arterial branch. Lymphocytes are scattered in and around the
    vessel. This happens to be polyarteritis nodosa, a systemic vasculitis that most often affects the
    kidneys. The P-ANCA serology is usually positive
    The microscopic appearance of the "end stage kidney" is similar regardless of cause, which is
    why a biopsy in a patient with chronic renal failure yields little useful information. The cortex is
    fibrotic, the glomeruli are sclerotic, there are scattered chronic inflammatory cell infiltrates, and
    the arteries are thickened. Tubules are often dilated and filled with pink casts and give an
    appearance of "thyroidization."
    Malignant hypertension:

    A: Fibrinoid necrosis of afferent arteriole

    B: Hyperplastic arteriolitis (onio-skin lesion)

    Courtesy of : Dr. H. Rennke, Dept Pathology, Brigham and Woman’s Hospital


    Chronic glomerulonephritis. Masson trichrome staining
    (blue staining collagen) Indicating sclerosis
    Tubules of epididymis within the center of an abscess in a case of
    acute epididymo-orchitis.
    High-grade papillary urothelial carcinomas display marked cytologic and architectural
    atypia. Within the papillary fronds, the neoplastic cells are arranged haphazardly with the
    loss of polarity. There is considerable variability in nuclear size and shape. The nuclei are
    hyperchromatic and prominent nucleoli are present. Mitotic activity is increased and
    mitoses may be found at all levels of urothelium. Some cases show numerous apoptotic
    cells.
    Radical cystectomy specimen
    showing extensive papillary
    tumors throughout the
    bladder.
    Genital Molluscum Contagiosum. This HIV-infected individual developed
    multiple, persistent molluscum lesions in the genital region. One of the
    lesions has the characteristic dome-shaped contour with central
    umbilication.
    Prominent Henderson-Patterson (molluscum) bodies (intracytoplasmic
    eosinophilic inclusions containing virus particles) in keratinocytes of
    stratum spinosum and granulosum
    Schiller-Duval body is a distinctive perivascular structure seen in the
    endodermal sinus pattern of yolk sac tumor. It consists of a central vessel
    surrounded by tumor cells – the whole structure being contained in a cystic
    space often lined by flattened tumor cells. It represents an attempt to form
    yolk sacs.
    At higher magnification, the enlarged prostate has glandular hyperplasia.
    The glands are well-differentiated and still have some intervening stroma.
    The small laminated pink concretions within the glandular lumens are
    known as corpora amylacea.

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