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    Cmv

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    Cmv

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    Cmv

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    7 views3 pages

    CMV

    Uploaded by

    bambangferdi irwanto
    Cmv

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 3

    CMV

     human herpesviruses

     Have a cell surface glycoprotein, acts as an Fc rec that can bind the Fc portion of Ig

     replicates in vitro only in human fibroblasts although the virus is often isolated from
    epithelial cells of the host.

     replicates very slowly in cultured cells, more slowly than that of HSV or varicella-zoster virus.

    PATHOGENESIS

     transmitted person-to-person in several different ways, all requiring close contact with virus-
    bearing material.

     There is a 4- to 8-week incubation period in normal older children and adults after viral
    exposure

     establishes lifelong latent infections

     can be shed intermittently from the pharynx and in the urine for months to years after
    primary infection
     Individuals at greatest risk for CMV disease are those receiving organ transplants, with
    malignant tumors, who are receiving chemotherapy, with AIDS.

     Viral excretion is increased and prolonged, and the infection is more apt to become
    disseminated.

     Pneumonia is the most common complication.

    CONGENITAL AND PERINATAL INFECTION

     Fetal and newborn infections with CMV may be severe

     About 1% of live births annually in the US have congenital CMV

     A high percentage of babies with this disease will exhibit developmental defects and mental
    retardation.

    TREATMENT AND CONTROL

     Ganciclovir. reduces the incidence of CMV pneumonia also controls progressive hearing loss
    in neonates with congenital infections.

     Foscarnet, an analog of inorganic pyrophosphate, is recommended for treatment of


    cytomegalovirus retinitis.

     Screening of transplant donors and recipients. The use of blood from seronegative donors
    has been recommended when infants will require multiple transfusions.
     Both live and recombinant cytomegalovirus vaccines are under development.

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