Help maintain body temperature and cell shape Help transport nutrients, gasses and wastes

 Is

used to indicate that other substances are also found in these compartments and that they influence the water balance in and between compartments.

Fluids  60% of an adult’s body weight * 70 Kg adult male: 60% X 70= 42 Liters  Infants = more water  Elderly = less water  More fat = ↓water  More muscle = ↑water  Infants and elderly - prone to fluid imbalance

60 %
Intracellular Fluid 40% or 2/3 Arterial Fluid 2% Extracellular Fluid 20% or 1/3

Intravascular 5% or 1/4

Interstitial 15% or 3/4

Venous Fluid 3%

Transcellular fluid 1-2% ie csf, pericardial, synovial, intraocular, sweat

Third-space fluid shift/Third “spacing”
- loss of ECF into a space that does not contribute to equilibrium between ICF and ECF ie ascites, burns, peritonitis, bowel obstruction, massive bleeding

Fluid Movement From Pressure Changes  fluids from different compartments move from one compartment to the other to maintain fluid balance.
 movement

is dictated by the transport mechanism principle : A. PASSIVE B. ACTIVE TRANSPORT

A. Passive Transport Process – substances transported across the membrane w/o energy input from the cell - high to low concentration

2 Types of Passive Transport
1. Diffusion – substances/solutes move from high concentration to low concentration ie exchange of O2 and CO2 b/w pulmonary capillaries and alveoli

2. Filtration – water and solutes forced through membrane by fluid or hydrostatic pressure from intravascular to interstitial area - solute containing fluid (filtrate) from higher pressure to lower pressure

B. Active Transport Process

2. 3. 4.

Cell moves substances across a membrane through ATP because: They may be too large Unable to dissolve in the fat core Move uphill against their concentration gradient

Types of Active Transport
1. Active transport – requires protein carriers using ATP to energize it
ie Amino acids Sodium potassium pump – 3Na out, 2K in

2. Endocytosis – moves substances into the cell 3. Exocytosis – moves substances out of the cell

Active Transport


Movement of water from low solute to high solute concentration in order to maintain balance between compartments. Osmotic pressure – amount of hydrostatic pressure needed to stop the flow of water by osmosis Oncotic pressure – osmotic pressure exerted by proteins




Regulation of Body Fluid
1. The Kidney  Regulates primarily fluid output by urine formation 1.5L  Releases RENIN  Regulates sodium and water balance

2. Endocrine regulation  thirst mechanism – thirst center in hypothalamus  ADH increase water reabsorption on collecting duct  Aldosterone increases Sodium and water retention retention in the distal nephron  ANP Promotes Sodium excretion and inhibits thirst mechanism

Atrial Natriuretic Peptide: Regulates Na+ & H2O Excretion

ADH Regulation
ADH - produced by the Hypothalamus - stored and secreted by the posterior pituitary gland  less water in plasma, ADH secreted to conserve water by reducing urine output  fluid overload in plasma, ADH secretion stops to excrete fluid in the kidneys by increasing urine output

ADH Disorder

Abnormally high ADH concentration - SIADH reduced urine output (oliguria) water retention (fluid overload) Abnormally low ADH – Diabetes Insipidus increased urine output (polyuria) water loss (fluid deficit)

3. Gastro-intestinal regulation - GIT digests food and absorbs water - Only about 200 ml of water is excreted in the fecal material per day 4. Heart and Blood Vessel Functions - pumping action of heart circulates blood through kidneys 5. Lungs – insensible water loss through respiration

Other Mechanisms
1. Baroreceptors – carotid sinus and aortic arch - causes vasoconstriction and increased blood pressure Dec arterial pressure SNS inc cardiac rate, contraction, contractility, circulating blood volume, constriction of renal arterioles and increased aldosterone

2. Osmoreceptors – surface of hypothalamus senses changes in Na concentration Inc osmotic pressure neurons dehydrated release ADH

Evaluation of fluid status
Osmolality – concentration of fluid that affects movement of water between fluid compartments by osmosis - measures the solute concentration per kg in blood and urine - reported as mOsm/kg - normal value= 280-300 mOsm/kg Osmolarity – concentration of solutions - mOsm/L

Intake and Output
I and O must be equal  2.6 L per day  Essential = Measurable = Sensible  Non essential = estimated Measurement= Insensible

Sources of Fluids Fluid Intake
1. Exogenous sources  Fluid intake 2, 600 ml oral liquids – 1, 300 ml water in food – 1, 000 ml water produced by metabolism – 300 ml
  

IVF Medications Blood products

2. Endogenous sources  By products of metabolism  secretions

Fluid Output Sensible loss  Urine - 1, 500 ml  Fecal losses – 200 ml Insensible loss  skin – 600 ml  Lungs – 300 ml

2, 600 ml

I&O Imbalance
Fluid Volume Deficit ↑output, normal intake  Normal output, ↓ intake  No intake or prolonged decreased intake

Causes of FVD
Vomiting, diarrhea, GI suctioning, sweating  Diabetes Insipidus  Adrenal insufficiency  Osmotic diuresis  Hemorrhage  3rd space fluid shift

Assessment of FVD
ICF cellular dehydration Acidosis  ITF skin poor skin turgor  IVF artery ↓BP, pulse (rapid thready) vein ↓CVP, ↓PAWP

Clinical manifestations
        

Weight loss Oliguria Concentrated urine Postural hypotension Flattened neck veins Increased Temp Dec CVP Thirst, anorexia Muscle weakness and cramps

BUN:Crea > 20:1  Inc Hct – RBC suspended in Dec plasma volume  Dec K – GI and renal losses  Inc K – adrenal insufficiency  Dec Na – inc thirst and ADH  Inc Na – insensible losses and DI

Medical Management
Oral intake when mild  IV route, acute or severe  Isotonic fluids ie LR for hypotensive patients to expand plasma volume  Assess I and O, weight, CVP, LOC, breath sounds and skin color  Fluid challenge test – 100-200 ml x 15 min

Nursing Management
Monitor and measure I and O  Monitor VS closely  Monitor skin turgor and tongue furrows  Monitor urinary concentration  Monitor mental function

Fluid Volume Excess ↑ intake, normal output  Normal intake, ↓ output  No output

Nursing Management
   

 

Measure intake and output Weigh daily 2 lb wt gain = 1 L fluid Assess breath sounds Monitor degree of edema ie ambulatory – feet and ankles bedridden – sacral area Promote rest – favors diuresis/inc venous return Administer appropriate medication

Causes of FVE

 

Heart failure, renal failure, cirrhosis of the liver – d/t aldosterone stimulation/Congestion Increased consumption of table salt Excessive administration of Na containing fluids in a patient w/ impaired regulatory mechanism SIADH

Assessment of FVE

ICF cellular edema ↓LOC pulmonary edema crackles (bibasilar), wheezing, shortness of breath, Inc RR ITF skin bipedal pitting edema, periorbital edema and ANASARCA IVF artery vein

↑BP, pulse (rapid bounding) ↑CVP, ↑PAWP

Clinical Manifestations
Distended neck veins  Tachycardia  Inc weight  Increased urine output  Shortness of breath and wheezing/crackles  Inc CVP

common manifestation of FVE  d/t inc capillary fluid pressure, decreased capillary oncotic pressure, increased interstitial oncotic pressure  Localized or generalized  Etiology: obstruction to lymph flow, plasma albumin level < 1.5-2 g/dl, burns and infection, Na retention in ECF, drugs

Labs: Dec Hct, respiratory alkalosis and hypoxemia, dec serum Na and osmolality, inc BUN Crea, Dec Urine SG, dec urine Na level Mgmt: diuretics, fluid restriction, elevation of extremities, elastic compression stockings, paracentesis, dialysis

Dec BUN  Dec Hct  CRF – serum osmolality and Na level dec  Cxr – pulmonary congestion

Medical Management
 

 

Discontinue administration of Na solution Diuretics ie Thiazide – block Na reabsorption in distal tubule Loop diuretics – block Na reabsorption in ascending loop of Henle Restrict fluid and salt intake Dialysis

Types of Fluid

• Tonicity - ability of solutes to cause osmotic driving forces

Isotonic Fluid - no movement of fluid.

Isotonic Fluids

0.9% NaCl/ Normal Saline/NSS -Na=154 -Cl=154 -308 mOsm/L - not desirable as routine maintenance solution - only solution administered with blood products Rx: hpovolemia, shock, DKA, metabolic alkalosis, hypercalcemia, mild NA deficit CI: caution in renal failure, heart failure and edema

D5W - 5% Dextrose in water - 170 cal and free water - 252 mOsm/L Rx: hypernatremia, fluid loss and dehydration CI: early post op when ADH inc d/t stress, sole treatment in FVD (dilutes plasma), head injury (inc ICP), flid resuscitation (hyperglycemia), caution in renal and cadiac dse (fluid overload), px with NA deficiency (peripheral circulatory collapse and anuria) 10% Dextran 40 in 5% Dextrose isotonic (252 mOsm/L)

Lactated Ringer’s Solution isotonic - Na 130 mEq/L - K 4 mEq/L -Ca 3 mEq/L - Cl 109 mEq/L - 273 mOsm/L Rx:hypovelemia, burns, flids lost as bile/diarrhea, acute blood loss CI: ph>7.5, lactic acidosis, renal failure(cause HyperK)

Hypotonic Fluid - fluid will enter the cell, the cell will swell

Hypotonic Fluids

0.45% NaCl (half strength saline) - provides Na, Cl and free water - Na 77 mEq/L - Cl 77 mEq/L - 154 mOsm/L Rx: hypertonic dehydration, Na and Cl depletion, gastric fluid loss CI : 3rd space fluid shifts and inc ICP

Hypertonic Fluid - fluid will go out from the cell, the cell will shrink

Hypertonic Fluids

3% NaCl (hypertonic saline) - no calories - Na 513 mEq/L - Cl 513 mEq/L -1026 mOsm/L Rx: critical situations to treat HypoNa, assist in removing ICF excess CI: administered slowly and cautiously (IVF overload and pulmonary edema) 5% NaCl

D10W - 10% Dextrose in water hypertonic (505 mOsm/L) D10W - 20% Dextrose in water hypertonic (1011 mOsm/L) D50W - 50% Dextrose in water hypertonic (1700 mOsm/L) D5NS - 5% Dextrose & 0.9NaCl hypertonic (559 mOsm/L) D10NS - 10% Dextrose & 0.9NaCl hypertonic (812 mOsm/L) D5LR - 5% Dextrose in Lactated Ringers hypertonic (524 mOsm/L

Colloid solutions

Dextran 40 in NS or 5% D5W - volume/plasma expander - decrease coagulation - remains for 6H in circulatory system Rx: hypovolemia in early shock, improve microcirculation (dec RBC aggregation) CI: hemorrhage, thrombocytopenia, renal disease and severe dehydration


elements or compounds when dissolved in water will dissociate into ions and are able to conduct an electric current.

FUNCTIONS: 1. Regulate fluid balance and osmolality 2. Transmission of nerve impulse 3. Stimulation of muscle activity

ANIONS - negatively charged ions: Bicarbonate, chloride, PO4-, CHON CATIONS - positively charged ions: Sodium, Potassium, magnesium, calcium

Regulation of Electrolyte Balance
1. Renal regulation  Occurs by the process of glomerular filtration, tubular reabsorption and tubular secretion  Urine formation
 If

there is little water in the body, it is conserved  If there is water excess, it will be eliminated

2. Endocrinal regulation  Aldosterone promotes Sodium retention and Potassium excretion  ANP promotes Sodium excretion  Parathormone increased bone resorption of Ca, inc Ca reabsorption from renal tubule or GI tract  Calcitoninoppose PTH  Insulin and Epinephrine – promotes uptake of Potassium by cells

The Cations

    

MOST ABUNDANT cation in the ECF 135-145 mEq/L Aldosterone increases sodium reabsorption ANP increases sodium excretion Cl accompanies Na

FUNCTIONS: 1. assists in nerve transmission and muscle contraction 2. Major determinant of ECF osmolality 3. Primary regulator of ECF volume


Na > 145 mEq/L Assoc w/ water loss or sodium gain
Etiology: inadequate water intake, excessive salt ingestion /hypertonic feedings w/o water supplements, near drowning in sea water, diuretics, Diabetes mellitus/ Diabetes Insipidus

S/SX: polyuria, anorexia, nausea, vomiting, thirst, dry and swollen tongue, fever, dry and flushed skin, restlessness, agitation, seizures, coma, muscle weakness, crackles, dyspnea, cardiac manifestations dependent on type of hypernatremia Dx: inc serum sodium and Cl level, inc serum osmolality, inc urine sp.gravity, inc urine osmolality

Mgmt: sodium restriction, water restriction, diuretics, isotonic non saline soln. (D5W) or hypotonic soln, Desmopressin Acetate for Diabetes Insipidus Nsg considerations History – diet, medication Monitor VS, LOC, I and O, weight, lung sounds Monitor Na levels Oral care initiate gastric feedings slowly Seizure precaution

 Na

< 135 mEq/L

 Etiology:

diuretics, excessive sweating, vomiting, diarrhea, SIADH, aldosterone deficiency, cardiac, renal, liver disease

 Dx:

dec serum and urine sodium and osmolality, dec Cl headache, apprehension, restlessness, altered LOC, seizures(<115meq/l),coma, poor skin turgor, dry mucosa, orthostatic hypotension, crackles, nausea, vomiting, abdominal cramping

 s/sx:

Mgmt: sodium replacement, water restriction, isotonic soln for moderate hyponatremia, hypertonic saline soln for neurologic manifestations, diuretic for SIADH Nsg. Consideration Monitor I and O, LOC, VS, serum Na Seizure precaution diet



Potassium (K)
     

MOST ABUNDANT cation in the ICF 3.5-5.5 mEq/L Major electrolyte maintaining ICF balance maintains ICF Osmolality Aldosterone promotes renal excretion of K+ Mg accompanies K

FUNCTIONS: 1. nerve conduction and muscle contraction 2. metabolism of carbohydrates, fats and proteins 3. Fosters acid-base balance

 

K+ > 5.0 mEq/L Etiology: IVF with K+, acidosis, hyper-alimentation and excess K+ replacement, decreased renal excretion, diuretics, Cancer s/sx: nerve and muscle irritability, tachycardia, colic, diarrhea, ECG changes, ventricular dysrythmia and cardiac arrest, skeletal muscle weakness, paralysis Dx: inc serum K level ECG: peaked T waves and wide QRS ABGs – metabolic acidosis

Mgmt: K restriction (coffee, cocoa, tea, dried fruits, beans, whole grain breads, milk, eggs) diuretics Polystyrene Sulfonate (Kayexalate) IV insulin Beta 2 agonist IV Calcium gluconate – WOF Hypotension IV NaHCo3 – alkalinize plasma Dialysis Nsg consideration: Monitor VS, urine output, lung sounds, Crea, BUN monitor K levels and ECG observe for muscle weakness and dysrythmia, paresthesia and GI symptoms

 

K+ < 3.5 mEq/L Etiology: use of diuretic, corticosteroids and penicillin, vomiting and diarrhea, ileostomy, villous adenoma, alkalosis, hyperinsulinism, hyperaldosteronism s/sx: anorexia, nausea, vomiting, decreased bowel motility, fatigue, muscle weakness, leg cramps, paresthesias, shallow respiration, shortness of breath, dysrhythmias and increased sensitivity to digitalis, hypotension, weak pulse, dilute urine, glucose intolerance

Dx: dec serum K level ECG - flattened , depressed T waves, presence of “U” waves ABGs - metabolic alkalosis Medical Mgmt: diet ( fruits, fruit juices, vegetables, fish, whole grains, nuts, milk, meats) oral or IV replacement Nsg mgmt: monitor cardiac function, pulses, renal function monitor serum potassium concentration IV K diluted in saline monitor IV sites for phlebitis

Normal ECG



  

Majority of calcium - bones and teeth Normal serum range 8.5-10.5 mg/dL Ca has an inverse relationship with PO4

FUNCTIONS 1. formation and mineralization of bones/teeth 2. muscular contraction and relaxation 3. cardiac function 4. blood coagulation 5. Promotes absorption and utilization of Vit B12

Regulation:  GIT absorbs Ca+ in the intestine with the help of Vitamin D  Kidney Ca+ is filtered in the glomerulus and reabsorbed in the tubules  PTH increases Ca+ by bone resorption, inc intestinal and renal Ca+ reabsorption and activation of Vitamin D  Calcitonin reduces bone resorption, increase Ca and Phosphorus deposition in bones and secretion in urine

 

Serum calcium > 10.5 mg/dL Etiology: Overuse of calcium supplements and antacids, excessive Vitamin A and D, malignancy, hyperparathyroidism, prolonged immobilization, thiazide diuretic s/sx: anorexia, nausea, vomiting, polyuria, muscle weakness, fatigue, lethargy Dx: inc serum Ca ECG: Shortened QT interval, ST segments inc PTH levels xrays - osteoporosis

Mgmt: 0.9% NaCl IV Phosphate Diuretics – Furosemide IM Calcitonin corticosteroids dietary restriction (cheese, ice cream, milk, yogurt, oatmeal, tofu)

Nsg Mgmt: Assess VS, apical pulses and ECG, bowel sounds, renal function, hydration status safety precautions in unconscious patients inc mobility inc fluid intake monitor cardiac rate and rhythm

 

Calcium < 8.5 mg/dL Etiology: removal of parathyroid gland during thyroid surgery, Vit. D and Mg deficiency, Furosemide, infusion of citrated blood, inflammation of pancreas, renal failure, thyroid CA, low albumin, alkalosis, alcohol abuse, osteoporosis (total body Ca deficit) s/sx: Tetany, (+) Chovstek’s (+) Trousseaus’s, seizures, depression, impaired memory, confusion, delirium, hallucinations, hypotension, dysrythmia

Dx: dec Ca level ECG: prolonged QT interval Mgmt: Calcium salts Vit D diet (milk, cheese, yogurt, green leafy vegetables) Nsg mgmt monitor cardiac status, bleeding monitor IV sites for phlebitis seizure precautions reduce smoking

Magnesium Mg
Second to K+ in the ICF  Normal range is 1.3-2.1 mEq/L

FUNCTIONS 1. intracellular production and utilization of ATP 2. protein and DNA synthesis 3. neuromuscular irritability 4, produce vasodilation of peripheral arteries

 

M > 2.1 mEq/L Etiology: use of Mg antacids, K sparing diuretics, Renal failure, Mg medications, DKA, adrenocortical insufficiency s/sx: hypotension, nausea, vomiting, flushing, lethargy, difficulty speaking, drowsiness, dec LOC, coma, muscle weakness, paralysis, depressed tendon reflexes, oliguria, ↓RR

Mgmt: discontinue Mg supplements Loop diuretics IV Ca gluconate Hemodialysis

Nsg mgmt: monitor VS observe DTR’s and changes in LOC seizure precautions


Mg < 1.5 mEq/l Etiology: alcohol w/drawal, tube feedings, diarrhea, fistula, GIT suctioning, drugs ie antacid, aminoglycosides, insulin therapy, sepsis, burns, hypothermia s/sx: hyperexcitability w/ muscle weakness, tremors, tetany, seizures, stridor, Chvostek and Trousseau’s signs, ECG changes, mood changes

Dx: serum Mg level ECG – prolonged PR and QT interval, ST depression, Widened QRS, flat T waves low albumin level Mgmt: diet (green leafy vegetables, nuts, legumes, whole grains, seafood, peanut butter, chocolate) IV Mg Sulfate via infusion pump Nsg Mgmt: seizure precautions Test ability to swallow, DTR’s Monitor I and O, VS during Mg administration

The Anions

Chloride (Cl)
  

The MAJOR Anion in the ECF Normal range is 95-108 mEq/L Inc Na reabsorption causes increased Cl reabsorption

FUNCTIONS 1. major component of gastric juice aside from H+ 2. together with Na+, regulates plasma osmolality 3. participates in the chloride shift – inverse relationship with Bicarbonate 4. acts as chemical buffer


Serum Cl > 108 mEq/L Etiology: sodium excess, loss of bicarbonate ions s/sx: tachypnea, weakness, lethargy, deep rapid respirations, diminished cognitive ability and hypertension, dysrhytmia, coma

Dx: inc serum Cl dec serum bicarbonate

Mgmt: Lactated Ringers soln IV Na Bicarbonate Diuretics Nsg mgmt: monitor VS, ABGs, I and O, neurologic, cardiac and respiratory changes


Cl < 96 mEq/l Etiology: Cl deficient formula, salt restricted diets, severe vomiting and diarrhea s/sx: hyperexcitability of muscles, tetany, hyperactive DTR’s, weakness, twitching, muscle cramps, dysrhytmias, seizures, coma

Dx: dec serum Cl level ABG’s – metabolic alkalosis

Mgmt: Normal saline/half strength saline diet ( tomato juice, salty broth, canned vegetables, processed meats and fruits avoid free/bottled water) Nsg mgmt: monitor I and O, ABG’s, VS, LOC, muscle strength and movement

Phosphates (PO4)
    

The MAJOR Anion in the ICF Normal range is 2.5-4.5 mg/L Reciprocal relationship w/ Ca PTH inc bone resorption, inc PO4 absorption from GIT, inhibit PO4 excretion from kidney Calcitonin increases renal excretion of PO4

FUNCTIONS 1. component of bones 2. needed to generate ATP 3. components of DNA and RNA


Serum PO4 > 4.5 mg/dL Etiology: excess vit D, renal failure, tissue trauma, chemotherapy, PO4 containing medications, hypoparathyroidism s/sx: tetany, tachycardia, palpitations, anorexia, vomiting, muscle weakness, hyperreflexia, tachycardia, soft tissue calcification

Dx: inc serum phosphorus level dec Ca level xray – skeletal changes

Mgmt: diet – limit milk, ice cream, cheese, meat, fish, carbonated beverages, nuts, dried food, sardines Dialysis Nsg mgmt: dietary restrictions monitor signs of impending hypocalcemia and changes in urine output

 

Serum PO4 < 2.5 mg/dl Etiology: administration of calories in severe CHON-Calorie malnutrition (iatrogenic), chronic alcoholism, prolonged hyperventilation, poor dietary intake, DKA, thermal burns, respiratory alkalosis, antacids w/c bind with PO4, Vit D deficiency s/sx: irritability, fatigue, apprehension, weakness, hyperglycemia, numbness, paresthesias, confusion, seizure, coma

Dx: dec serum PO4 level

Mgmt: oral or IV Phosphorus correction diet (milk, organ meat, nuts, fish, poultry, whole grains) Nsg mgmt: introduce TPN solution gradually prevent infection

Acid Base Balance

- substance that can donate or release hydrogen ions ie Carbonic acid, Hydrochloric acid ** Carbon dioxide – combines with water to form carbonic acid

Base - substance that can accept hydrogen ions Ie Bicarbonate

BUFFER- substance that can accept or donate hydrogen - prevent excessive changes in pH

TYPES OF BUFFER 1. Bicarbonate (HCO3): carbonic acid buffer (H2CO3) 2. Phosphate buffer 3. Hemoglobin buffer

Dynamics of Acid Base Balance

  

Acids and bases are constantly produced in the body They must be constantly regulated CO2 and HCO3 are crucial in the balance A HCO3:H2CO3 ratio of 20:1 should be maintained Respiratory and renal system are active in regulation

- Regulate bicarbonate level in ECF 1. RESPIRATORY/METABOLIC ACIDOSIS - kidney excrete H and reabsorbs/generates Bicarbonate 2. RESPIRATORY/METABOLIC ALKALOSIS - kidney retains H ion and excrete Bicarbonate


Control CO2 and Carbonic acid content of ECF

1. METABOLIC ACIDOSIS - increased RR to eliminate CO2 2. METABOLIC ALKALOSIS - decreased RR to retain CO2

pH - measures degree of acidity and alkalinity - indicator of H ion concentration - Normal ph 7.35-7.45

ACIDOSIS - decreased pH; < 7.35 - increased Hydrogen

ALKALOSIS - increased pH-; > 7.45 - decreased Hydrogen

ACUTE AND CHRONIC METABOLIC ACIDOSIS Low pH - Increased H ion concentration - Low plasma Bicarbonate Etiology: diarrhea, fistulas, diuretics, renal insufficiency, TPN w/o Bicarbonate, ketoacidosis, lactic acidosis S/sx: headache, confusion, drowsiness, inc RR, dec BP, cold clammy skin, dysrrythmia, shock

Dx: ABG – low Bicarbonate, low pH, Hyperkalemia, ECG changes Rx: Bicarbonate for pH < 7.1 and Bicarbonate level < 10 monitor serum K dialysis

  

High pH Decreased H ion concentration High plasma Bicarbonate

Etiology: vomiting, diuretic, hyperaldosteronism, hypokalemia, excesive alkali ingestion s/sx: tingling of toes, dizziness, dec RR, inc PR, ventricular disturbances

Dx:ABG – pH > 7.45, serum Bicarbonate > 26 mEq/L, inc PaCO2

Rx: restore normal fluid balance correct hypokalemia Carbonic anhydrase inhibitors


Ph < 7.35 PaCO2 > 42 mmHg

Etiology: pulmonary edema, aspiration, atelectasis, pneumothorax, overdose of seatives, sleep apnea syndrome, pneeumonia s/sx: sudden hypercapnia produces inc PR, RR, inc BP, mental cloudinesss, feeling of fullness in head, papiledema and dilated conjunctival blood vessels

Dx: ABG – pH < 7.35 PaCO2 - > 42 mmHg Rx: improve ventilation pulmonary hygiene mechanical ventilation

 

pH > 7.45 PaCO2 < 38 mmHg

Etiology: extreme anxiety, hypoxemia s/sx: lightheadednes, inability to concentrate, numbness, tingling, loss of consciousness

Dx: ABG – pH > 7.45 PaCO2 < 35 dec K dec Ca

Rx: breathe slowly sedative

Parameter pH PaCO2 HCO3 O2 saturation Normal Value 7.35 – 7.45 35 – 45 mmHg 22-26mEq/L 93 - 98%

Evaluating ABG’s

Note the pH pH = 7.35 – 7.45 (normal) pH = < 7.35 (acidosis) pH = > 7.45 (alkalosis) compensated – normal pH uncompensated – abnormal pH

2. Determine primary cause of disturbance 2.1 pH > 7.45 a. PaCo2 < 40 mmHg – respiratory alkalosis b. HCO3 > 26 mEq/L – metabolic alkalosis 2.2 pH < 7.35 a. PaCo2 > 40 mmHg – respiratory acidosis b. HCO3 < 26 mEq/L – metabolic acidosis

3. Determine compensation by looking at the value other than the primary disturbance pH 7.20 PaCO2 HCO3 60 mmHg 60 mmHg 24 mEq/L 37 mEq/l
Uncompensated Respiratory acidosis Compensated Respiratory acidosis


4. Mixed acid-base pH disorders
Metabolic and Respiratory Acidosis


Dec acid



Inc acid



Dec acid

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