Professional Documents
Culture Documents
Emerging Chemicals
Emerging Chemicals
BUITENWERELD
Welke chronische effec ten moeten worden bestudeerd aangezien de ES geen acuut gevaar opleveren ?
BUITENWERELD
on CD-ROM
European Chemical Bureau : IUCLID
Publisher : Samson
ISIS : Internationaal Stoffen Informatie Systeem
bevat : RTECS, AQUIRE, IRPTC
DATA BANKS ON HAZARDOUS CHEMICALS on CD-ROM
Publisher : Syracuse Research Corporation
Philip Howard: Handbook of Environmental Fate and Exposure Data for
Organic Chemicals (18.000 chemicals).
Philip Howard : Handbook of Environmental Degradation Rates
CHEMFATE : 1728 substances
BIODEG : 700 substances
Publisher : CRC
Donals Mackay: Illustrated Handbook of Physical-Chemical properties and
Environmental fate for Organic Chemicals (± 500 substances)
Publisher : MDL
MDL Metabolite Database : Biotransformations of Drugs and Pharmacokinetics
(8600 parent compounds, 54.000 transformations; 35.000 molecules)
EINECS
EINECS includes a large variety of chemical substances, for example (cf. [17-19]):
– industrial chemicals;
– substances produced from natural products by chemical modifi cation or
purifi cation, such asmetals, minerals, cement, refined oil and gas and their products
including pitch;
– substances produced from animals and plants, such as lanolin, turpentine, rosin oil
and resin acids, except where they are used solely in foodstuffs;
– food additives;
– ingredients or active substances of pesticides, medicaments, such as aspirin and
paracetamol, and cosmetic products;
• m onom ers;
• naturalpolym ers, including natural rubber nda tsarch ;
• some w aste and by-products, including som e by-productsof processed coal, such as
coke and coal art iptch.
EINECS does not include
1. synthetic polymers (these are registered in EINECS under their
building blocks, monomers);
2. impurities as such, although some may beon EINECS in their own
right;
3. intentional mixtures;
4. medical products, cosmetic products and pesti cide products as
intentional mixtures;
5. food, feedstuffs;
6. alloys, such as stainless steel, but inc ludes most individual
components of al loys;
7. most naturall y occurring raw materials, including coal and most
ores.
8. degradates
New Chemicals : since 1981 : 4000 chemicals
Intermediates 24%
Colouring agents 16%
Photochemicals 8%
Cosmetics 6%
Process regulators 5%
Stabilisers 4%
Pharmaceuticals 3%
Odour agents 3%
Reprographic agents 2%
Others 29%
The HEDSET and the IUCLID
4 Ecotoxicity
4.1 Acute/Prolonged Toxicity to Fish 67.95%
4.2 Acute Tox. to Aquatic Invertebrates 54.65%
4.3 Toxicity to Aquatic Plants e.g. Algae 45.56%
4.4 Tox. to Microorganisms e.g. Bacteria 56.92%
4.5.1 Chronic Toxicity to Fish 13.71%
4.5.2 Chronic Tox. to Aquatic Invertebrates 17.77%
4.6.1 Toxicity to Soil Dwelling Organisms 30.30%
4.6.2 Toxicity to Terrestrial Plants 31.76%
4.6.3 Tox. to Other Non-mamm. Terr. Species 32.70%
4.7 Biological Effects Monitoring 25.80%
4.8 Biotransformation and Kinetics 26.98%
IUCLID : Beschikbaarheid van gegevens
5 Toxicity
5.1.1 Acute Oral Toxicity 76.96%
5.1.2 Acute Inhalation Toxicity 50.75%
5.1.3 Acute Dermal Toxicity 52.94%
5.1.4 Acute Toxicity, Other Routes 35.01%
5.2.1 Skin Irritation 73.27%
5.2.2 Eye Irritation 72.90%
5.3 Sensitisation 48.32%
5.4 Repeated Dose Toxicity 58.17%
5.5 Genetic Toxicity in Vitro 66.94%
5.6 Genetic Toxicity in Vivo 37.89%
5.7 Carcinogenicity 43.89%
5.8 Toxicity to Reproduction 26.00%
5.9 Developmental Toxicity/Teratogenicity 32.01%
5.10 Other Relevant Information 51.93%
5.11 Experience with Human Exposure 55.94%
LLINCWA
Loss Lubrication in Inland and Coastal Water
Activities
University of Amsterdam, Chemiewinkel (UvA-CW).
TotalFinaElf Lubricants.
1.4 Ana lysis o f pro duc ts and c o ntro l o n b iodeg rada tio n
1.5 Tes t the perfo rmance of th e lubrican ts
1.6 Identify and solve technical problems
Nancy Sager
Center for Drug Evaluation and Research
FDA, Food and Drug Administration
C.G. Daughton
Chief Environmental Chemistry Branch
Environmental Science Division, EPA
P. Frier
LGC
PRELIMINARY CONCLUSIONS
1. Degradates (= metabolites) are more important then parent compounds
2. Ecological fate and toxicity data are lacking for the majority of the degradates
3. M any substances are mixtures of more then 10 compounds
4. Information on composition of many preparations is lacking
5. Information on volumes and uses of Emerging Substances is restricted to:
a. pharmaceuticals
b. cosmetics
c. brominated and phosphate flame retardants
d. pesticides
e. ozone depleting substances
f. plasticizers (phthalates)
g. non-agricultural biocides (in personal care products)
6. Ecological fate and toxicity data are available for ± 5000 substances
7. Number of Emerging Substances to be investigated estimated at ±20.000
Risk assessment of hazardoussubstances is generally based on acute toxicity and
not on chronic toxicity
BTO
BRON-PAD-DOEL MILIEUGEVAARLIJKE STOFFEN
Emissies:
- samenstelling Transport- en Concentraties
Product - hoeveelheden Transformatie- en effecten
bij Waterzuivering
samenstelling - plaats processen
- compartiment in het milieu blootstelling
Map of knowledge
Establish and regularly update Inventory of risk analysis methods
list of identified Emerging Substances and micro-organisms Early detection methods
PROJECTPLAN BTO
Identificatie bijdrage VITENS aan projectplan BTO
Vitens-BTO
PROJECTPLAN BTO (2002-2004) EUR EUR % % VITENS
1 Workshop € 60.000 16
1.1 Startdocument workshop € 24.000 6,4
1.2 Interactive workshop € 30.000 8,0
1.3 Proceedings workshop € 6.000 1,6
1 Workshop € 60.000 16
1.1 Startdocument workshop € 24.000 6,4
1.2 Interactive workshop € 30.000 8,0
1.3 Proceedings workshop € 6.000 1,6