Antiinflammatory Test of The Cashew Leaves

Inflicted In Sole Foot of The Male Rats

Presented by :
1. Graha Ayu Praptiwi
2. Junita Bri Hastuti
3. Ruri Oktavianti

ABSTRAK
PROGRAM DIPLOMA III
AKADEMI FARMASI HANG TUAH JAKARTA
KTI, JUNI 2014

Nama
: Graha Ayu Praptiwi
Junita Bri Hastuti
Ruri Oktavianti
Judul KTI : Uji Antiinflamasi Daun Jambu Mete ( Anacardium occidentale Linn ) yang ditimbulkan pada Telapak Kaki Tikus
Putih Jantan
Tahun Penulisan : 2014
Jumlah Halaman: 30 halaman
Rangkuman

Inflamasi merupakan suatu respon protektif normal terhadap luka jaringan yang disebabkan oleh trauma fisik, zat kimia yang
merusak atau zat mikrobiologi. Salah satu tumbuhan yang dapat dimanfaatkan sebagai bahan obat tradisional untuk
antiinflamasi adalah daun jambu mete. Penelitian ini bertujuan untuk mengetahui pengaruh antiinflamasi ekstrak ethyl asetat
dalam daun jambu mete pada telapak kaki tikus jantan dibandingkan dengan natrium diklofenak.
Penelitian ini menggunakan desain penelitian eksperimental dengan tiga puluh tikus putih jantan berumur 2 3 bulan, berat
150 250 gram dan dibagi dalam enam kelompok. Tikus diadaptasi dan diberikan minum selama 18 jam. Tikus ditimbang berat
badannya dan kedua kaki belakang diberi tanda sebatas siku kemudian diukur volume telapak kaki tikus dengan pletismometer
sebagai volume sebelum diradangkan. Setelah 1 jam, keenam kelompok diinjeksi dengan karagenin 0,5% 0,5mL. Kemudian
diukur volume telapak kaki tikus dengan pletismometer setiap 30 menit mulai dari menit ke-0 sampai menit ke-300.
Hasil penelitian menunjukkan ekstrak etil asetat daun jambu mete (Anacardium occidentale L.) dosis 450 mg/kg bb, 900
mg/kg bb, 1,8 g/kg bb mempunyai efek antiinflamasi terhadap edema pada telapak kaki tikus putih jantan yang diinduksi
karagenin 0,5% 0,5ml. Dosis campuran antara ekstrak etil asetat daun jambu mete dosis 900mg/kg bb + natrium diklofenak
3,357mg/kg bb memiliki efek antiinflamasi yang lebih kecil jika dibandingkan dengan ekstrak etil asetat daun jambu mete
dosis 450mg/kg bb dan 900mg/kg bb, tetapi mereka masih lebih rendah dari natrium diklofenak.
Kata Kunci : Daun Jambu Mete ( Anacardium occidentale Linn ), Volume Edema, Ekstrak Ethyl Asetat

ABSTRACT
DIPLOMA III PROGRAMME
HANG TUAH PHARMACEUTICAL COLLEGE JAKARTA
RESEARCH, JUNI 2014

Name

: Graha Ayu Praptiwi

Junita Bri Hastuti
Ruri Oktavianti
Title of Research
: Antiinflammatory Test of The Cashew Leaves (Anacardium occidentale L.)
Inflicted In Sole Foot of The Male Rats
Year of Research
: 2014
Number of Research : 30 pages
Summary :

Inflammation is a normal protective response to tissue injury caused by physical trauma, damaging
chemicals or microbiological substances. One of the plants that can be used as traditional medicine for
anti-inflammatory cashew leaves. This research aimed to determine the effect of anti inflammation ethyl
acetate extract of cashew leave (Anacardium occidentale L.) on edema in sole foot of male rats compared
with natrium diclofenac.
This research was a laboratory design using experimental method. Thirty rats (2-3 month) of 150250 gr were used in this study and divided into 6 groups (5 rats each). The rats were fasted and drinks
water was given for 18 hours. Before rats were treated, the sole foot of rats were measured by
pletismometer. After 1 hours, they were injected with karagenin 0,5% 0,5 ml. The edema volume in sole
foot were measured every 30 minute until 300 minute.
This result showed it was concluded that ethyl acetate extract of cashew leave with doses
450mg/kg BW, 900mg/kg BW, 1,8g/kg BW and 900mg/kg BW + Na diclofenac doses 3,375mg/kg BW have
the antiinflammatory effect on edema in sole foot of male rats induced by karagenin but those are still
lower than natrium diclofenac.
Keywords

: Cashew Fruit (Anacardium occidentale L.), edema volume, ethyl acetate extract

P
1

Background

Inflammation is a normal protective response

to tissue injury caused by physical trauma,
damaging
chemicals
or
microbiological
substances. One of the plants that can be used
as traditional medicine for anti-inflammatory
cashew leaves. This research aimed to
determine the effect of anti inflammation
ethyl acetate extract of cashew leave
(Anacardium occidentale L.) on edema in sole
foot of male rats compared with natrium
diclofenac.

P
2

Purpose & Methods of

Research

This research was a laboratory design using

experimental method. Thirty rats (2-3 month)
of 150-250 gr were used in this study and
divided into 6 groups (5 rats each). The rats
were fasted and drinks water was given for 18
hours. Before rats were treated, the sole foot
of rats were measured by pletismometer. After
1 hours, they were injected with karagenin 0,5%
0,5 ml. The edema volume in sole foot were
measured every 30 minute until 300 minute.

P
1

Result of The Research

This result showed it was concluded that

ethyl acetate extract of cashew leave with
doses 450mg/kg BW, 900mg/kg BW, 1,8g/kg
BW and 900mg/kg BW + Na diclofenac doses
3,375mg/kg BW have the antiinflammatory
effect on edema in sole foot of male rats
induced by karagenin but those are still lower
than natrium diclofenac.

Bibliographies
Pawar, S.P, Sathwane, P.N, Metkar, B.R, Pal, S.C, dkk,
Anti Inflammatory and Analgesic of Anacardium
occidentale Linn Leaf Extracts. PMC. 2000 ; 169-173.
Sutrisna, E.M., Widyasari, Domas., Suprapto, Uji Efek
Anti Inflamasi Ekstrak Etil Asetat Buah Semu Jambu
Mete ( Anacardium occidentale Linn) terhadap Edema
pada Telapak Kaki Tikus Putih (Rattus norvegicus) Jantan
Galur Wistar yang Diinduksi Karagenin, Universitas
Muhammadiyah Surakarta. Biomedika. 2010 ; II. 1
Patil, MB,. Jalalpure, SS., Pramod, HJ., Manvi, FV., Anti
Inflammatory Activity of The Leaves of Anacardium
occidentale Linn. Mumbai, 2003, Vol. 65.