Professional Documents
Culture Documents
OBSTETRIC &
GYNECOLOGY
NEW DEVELOPMENTS OF
THE EFFECT OF
MELATONIN ON
REPRODUCTION
Fanuel Lampiao, Stefan S Du Plessis
Presented by:
Adipta Kurniawan, S. Ked.
Facilitator:
dr. Maruarar Panjaitan, Sp.OG.
DEPARTMENT OF OBSTETRIC & GYNECOLOGY
FACULTY OF MEDICINE CHRISTIAN UNIVERSITY OF
INDONESIA
UKI General Hospital
February 29th, 2016 May 7th, 2016
INTRODUCTION
Melatonin (N-acetyl-5-methoxytryptamine) is
responsible for the regulation of a variety of
central and peripheral actions relate to circadian
rhtyms and reproduction.
Melatonin primarily synthesized and secreted by
the pineal gland
The role of melatonin in human reproduction:
Regulate the reproductive neuroendocrine axis
PINEAL MELATONIN
BIOSYNTHESIS AND REGULATION
Suprachiasmatic Nucleus
(SCN) regulate the circadian
melatonin reproduction.
Melatonin is formed in the
pineal gland.
Melatonin release into the
blood and metabolized in the
liver.
EFFECT OF MELATONIN ON
PUBERTY
Influence on the hypothalamic secretion of GnRH in
humans.
Decline the trigger signals of GnRH.
High nocturnal melatonin secretion in children delays
puberty.
High levels of melatonin have been associated with
amenorrhea.
Decreased GnRH/LH secretion.
Irregularities in hypothalamic pituitary ovarian axis
functioning.
Melatonin containing GnRH secreting neurons.
Leads to the down regulation of GnRH.
EFFECT OF MELATONIN ON
PREGNANCY
Increases intra-follicular melatonin
concentrations
Reduces intrafollicular oxidative damage
Elevates fertilization and pregnancy rates
Regulation of the circadian rhythm in the fetus
Modulating fetal clock gene function
Modulate the strength of affinity gap junctions
in myometrium
Powerful labor inducing forces
CONCLUSION
Melatonin has multiple physiological roles
Melatonin mediated in hypothalamus and pituitary
gland
Melatonin as an antioxidant
Melatonin reduce oxidative stress in oocyte maturation
and embrio development
Increases intrafollicular melatonin concentration in
women with infertility
Elevates fertilization and pregnancy rates
Melatonin treatment could become a new cure for
improving oocyte and sperm quality in infertile patients
REFERENCES