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Background
*Kotake S. Nihon Naika Gakkai Zasshi [Rheumatoid arthritis and osteoporosis]. 2005; 94(4):649-655
University of Medicine and Pharmacy of Craiova
Background
osteoporosis is the main complication of RA
Aim
T-score*
Normal
-1.0
Osteoporosis
-2.5
Severe
(established)
osteoporosis
-2.5 and
fragility fracture
Results
Osteoporosis - 21.6% patients, both for
lumbar spine and total hip
Osteoporosis- 38.5% for one site
Osteopenia-32%
Results
Mean value-DAS28(4v) -4.78
Results
FRAX-4.716.03% (min 0, max 37)hip and
11,968.18% (min 1.7%, max 46%) for a
major osteoporotic fracture
50
40
30
Mean
IC
95%
DS
Median
Min
Max
20
10
FRAX-major
osteoporotic
fracture (%)
11.96
10.5113.41
8.1
8
1.7
46
FRAX-hip (%)
4.71
3.655.78
6.0
3
2.3
37
Results
29.6% (37)-vertebral fractures
9 patients2 fractures
Location -
9
6
4
1
T10,T12, L1
T11, L2
L3
T8,T9
Grade -67.56%-1
-40.45%-2
-13.51% grade 3
University of Medicine and Pharmacy of Craiova
Results
48 osteoporosis-20 VF
40 osteopenia-4VF
RR 6.64 (%)
Results
54% DAS28(4v)>5,1-at least one VF
15.78% moderate activity score-at least one
VF
10
8
6
4
2
0
p<0.0001
Results
DAS28(4v)
r
0.482
<0.0001
IC95%
0.33-0.60
r2
0.233
Conclusions
Conclusions
Conclusions
Establishing the profile of vertebral fractures
we found a significant percentage among the
AR patients, fact that testifies the risk of
functional impairment and disability, added
to the underlying disability of the disease
itself, in the absence of a quick therapeutic
action
Conclusions
Medicine is a science of
uncertainty and an art of
probability
William Osler
Thank you!
University of Medicine and Pharmacy of Craiova