History of Mass

Spectrometry

J. J. Thomson Parabola Mass

Spectrometer (1912)

Birth of Modern Techniques

Dempster (1918)
Developed electron ionization and magnetic focusing

Aston (1919)
Atomic weight using MS

Birth of Modern Techniques

Stephens (1946)
Time of Flight MS

Nier- Johnson (1952)

Double Focusing Instruments

Paul, Steinwedel, Raether, Reinhard, and von Zahn (19531958)

Quadrupolr alanlyzers

Birth of Modern Techniques

Wiley and Mclaren (1955)
Advanced the time-of-flight mass analyzer design

Gohlke and Mclafferty (1956)

Gas chromatography-mass spectrometry (GC-MS)

Beynon(1956)
High-resolution MS

Birth of Modern Techniques

Biemann, Seibl and Gapp (1959)
Peptide Sequencing

Hipple, Sommer and Wabschall (1965)

Ion cyclotron resonance

Munson and Field(1966)

Chemical Ionization

Birth of Modern Techniques

McLafferty and Jennings(1967)
Tandem MS

Dole, Mack, Hines, Mobley Ferguson, Alice(1968)

Electrospray ionization

Becky(1969)
Field desorption MS of Organic Molecules

Birth of Modern Techniques

McLafferty (1973)
Liquid Chromatography MS

MacFarlane, Skowronski and Torgerson (1974)

Plasma desorption MS

Comisarow and Marshall(1974)

Fourier transform ion cyclotron resonance MS

Birth of Modern Techniques

Barber, Bordoli, Sedgwick and Tyler; Surman and Vickerman
(1981)
Fast atom bombardment MS

Blakely and Vestal (1983)

Thermospray MS

Yamashita and Fenn; Aleksandrov, Gall, Krasnov, Nikolaev,

Pavlenko, Shkurov, Dokl, Baram, and Garacher (1984)
Application of electrospray ionization to macromolecules

Birth of Modern Techniques

Karas, Bachmann, Bahr, and Hillenkamp; Tanaka, Waki, Ido,
Akita, Yoshida, and Yoshida (1987-1988)
Matrix-assisted laser desorption/ ionization (MALDI)-MS

Henry, Williams, Wang, McLafferty, Shabanowitz, and Hunt

(1989)
Electrospray and ion cyclotron resonance MS

Katta and Chait (1990)

Observation of protein conformational changes with electrospray
MS

Birth of Moden Techniques

Wilm (1991)
Microelectrosparay

Henion and Ganem; Chait and Katta (1991)

Noncovalent complexes observed with electrospray MS

Chait, Wang, Beavis, and Kent (1993)

Protein ladder sequencing with
MALDI-MS

Pieles, Zurcher, Schar, and Moser; Fitzgerald, Zhu, and Smith

(1993)
Oligonucleotide sequencing with
MALDI-MS