ANTI LEUKEMIA

ISWANDI DARWIS

Pharmacology and Therapy

dical Faculty University of Lampu

Goal Anticancer Agent

1. Stop
2.
3.
Damage
Inhibit
mitosis
the
the
synthesis
or
DNA
theofactual
the
of new
affected
splitting
DNA strands
cancer
of thecells.
to
original
stop the
cellcell
intofrom
two replicatin
new cells

Catagories of Chemotherapy
Drugs based on MOA
Stop the synthesis of pre DNA molecule building blocks

Methotrexate

5-Fluorouracil
5-Fluorouracil is an effective

Hydroxyurea
In addition, DNA
Hydroxyurea
blocks
synthesis
an enzyme
is further
which
inhibited
convertsbecause
the cytosine
nucleotide into
hydroxyurea
blocks
the deoxy
the incorporation
derivative. of the thymidine nucleotide
into the DNA strand.

Mercaptopurine

Mercaptopurine, a chemical analog of the purine adenine, inhibits the b

Thioguanine
Thioguanine

Alkylating Agents
Alkylating

Antibiotics

anthracyclines, dactinomycin, bleomycin, adriamycin, mithramycin, bin

Mitotic Disrupters

Intercalating Agents

The intercalated drug molecules affect the structure of the DNA, preventi

Treatment of Acute Limphoblastic

Leukemia

Treatment of Chronic Limphocytic

Leukemia
Chlorambucil

Treatment of Acute Myeloblastic

Leukemia
Induction of Remission

Treatment of Chronic Myelocytic

Leukemia
Ninety percent of patients who are treated with

THANKS

QUESTIONS
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