GUILLAINE BARRE

SYNDROME
Metty Tusiana
1102012162

Lecturer Adviser :
Dr. Donny H. Hamid SpS

DEFINITION

ETIOLOGY

PATHOPHYSIOLOGY
IMMUNOPATHOLOGY

DIAGNOSIS

TREATMENT

PROGNOSIS

DEFINITION
Guillain-Barr syndrome (GBS) is a disorder in which
the body's immune system attacks part of the peripheral
nervous system. The first symptoms of this disorder
include varying degrees of weakness or tingling
sensations in the legs. In many instances the
symmetrical weakness and abnormal sensations
spread to the arms and upper body. These symptoms
can increase in intensity until certain muscles cannot be
used at all and, when severe, the person is almost
totally paralyzed.

ETIOLOGY
70% cases of GBS occur 1-3 weeks after an acute infectious
process, usually respiratory or gastrointestinal.

1. Campylobacter Jejuni
2. Cytomegalovirus
3. Other Infections (Epstein-Barr
Virus, Varicella Zoster, etc)

Pathophysiology

Campylobacter jejuni
bacteria

Start to react to the

gangliosides and
glycolipids on the
peripheral
nerves/roots/ganglia.

APC engulfed the

bacteria and
presented to CD4

IgG goes in to the

circulation

CD4 produces
inflammatory
mediator

Activate B-Cell to
produce IgG

Damages the
peripheral nervous
system.

Diagnosis

Treatment

Prognosis

Approximately 85% of patients with GBS achieve

a full functional recovery within several months to
a year, although minor findings on examination
(such as areflexia) may persist.
The mortality rate is <5% in optimal settings;
death usually results from secondary pulmonary
complications.
The outlook is worst in patients with severe
proximal motor and sensory axonal damage.
Between 5 and 10% of patients with typical GBS
have one or more late relapses