NK cytokine

uNK CELL CYTOKINES

PARTNERSHIP of uNK and

eVT FUNGSI
SITOKIN
uNK

IL-8

Stimulate recruitment and migration of eVT

Promote up-regulation of MMP-2 and MMP9invasion of eVT cell line and reduce eVT
apoptosis
Increase expression of integrins 1 and 5
as integrin for eVT differentiation

INF- IP-10

Stimulate recruitment and migration of eVT

RANTES
kemokin

Regulate trofoblas migration

HGF

Induce motility in an eVT cell line

LIF

Activation of Stat3 to regulate trophoblast

invasion

VEGF

Increase O2 delivery to the site of placentation

for trophoblast differentiation

VEGF-C

Increasing eVT resistance to cytotoxicity

Promoting the assembly of eVT into
networks of tuba-like structures
and Tian,
2007;
Wallace et
Disrupt the (Zhang
VSMC layer
of spiral
artery