ESPONDILOARTROPAT

IAS SERONEGATIVAS
Walter Espino Saavedra
Mdico AnatomoPatologo
Universidad Seor de Sipn
USS

normal synovium

normal cartilage

ESPONDILITIS
ANQUILOPOYETIC
A

ARTRITIS
PSORIASICA

Artritis psoriasica

Artritis psoriasica

La Esclerosis
Sistmica
(esclerodermia)

Histopathology of mature scleroderma; full-thickness sclerosis of

the dermis. Photomicrograph courtesy of Dirk Elston, MD.

ESCLERODERMIA
LOCALIZADA

In early stages of progressive systemic sclerosis, mucoid changes in the vessel wall predominate, with swollen endothelium and a mucoid
appearance of the subintima, frequently with red blood cell fragments, as seen here. (Jones' silver stain, original magnification X400).

In the more chronic stage of progressive systemic sclerosis, fibrous organization of the intimal injury results in a lamellated "onion
skin" appearance of arteries. (Periodic acid Schiff, original magnification X400).

Pathology slides show scleroderma lung and pulmonary arterial hypertension. The gross
appearance with lower lobe fibrosis and honeycomb change is identical to that of
idiopathic pulmonary fibrosis (A). An artery has medial hypertrophy (M) and intimal
hyperplasia (I) (Elastica van Gieson stain, original magnification 100) (B). A vein (V) in
the interlobular septum shows marked thickening resulting from intimal hyperplasia
(trichrome stain, original magnification 100) (C). (Images courtesy of Dr Michael
Fishbein.)

Hyperplastic
Arteriosclerosis at 40x
Magnification -Lung

ESCLEROSIS
DE LA PARED
MUSCULAR
ESOFAGICA