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PATHOPHYSIOLOGY

OF
OSTEOPOROSIS
ANN KIN C. NG
BSN 4-1, GROUP 6

Risk Factors
Modifiable

Non-modifiable
Increased age
Female
Race
Positive
family
history
Body frame (small
and thin)

Diameter of bone
increases, thinning outer
supportive cortex
Trabeculae (spongy tissue)
lost and outer cortex thins
Minimal stress leadsto
fracture

Low Calcium and Vitamin D


intake, lack of sunlight
exposure
Sedentary lifestyle
(inactive, immobility)
Alcohol abuse
Smoking
Caffeine, soft drinks
(phosphoric acid)
Corticosteroids, anticonvulsants (Dilatin or
phenobarbital), thyroid
hormones

Loss of height
Low back pain
Progressive curvature of
spine (dorsal kyphosis,
cervical lordosis)
Fractures of forearm, spine or
hip

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