Katabolisme Asam Nukleat

Katabolisme Nukleotida

Katabolisme:

Polinukleotida
oligonukleotida
mononukleotida
nukleosida

CO2

Fosfat

Gula

Basa Nitrogen

H 2O

ATP

Amonium
Urea
-ureidoisobutirat
Asam urat -aminoisobutirat,
Allantoin
metilmalonil semialdehid
Allantoat

NUKLEOTIDA

DEOKSIRIBONUKLEOTIDA

RIBONUKLEOTIDA

Pemecahan Nukleotida

Pemecahan DNA
Pemecahan RNA
Pemecahan basa purin
Pemecahan basa pirimidin

Secara Umum :

Pemecahan Polinukleotida
oligonukleotida
Polinukleotida
mononukleotida
Fosfat +
nukleosida
Basa Nitrogen + Gula

Katabolisme Purin

Seluruh purin yg melebihi keperluan

sintesis polinukleotida, akan dipecah.
As urat

encok

FIGURE2245Catabolismofpurine
nucleotides.Notethatprimatesexcrete
muchmorenitrogenasureaviathe
ureacycle(Chapter18)thanasuric
acidfrompurinedegradation.
Similarly,fishexcretemuchmore
nitrogenasNH4+thanasureaproduced
bythepathwayshownhere.

DegradationofPurinesandPyrimidinesProduces
UricAcidandUrea,Respectively

ExcessUricAcidCausesGout

Katabolisme Pirimidin

Thepathwaysfordegradationofpyrimidinesgenerally
leadtoNH4productionandthustoureasynthesis.

Thepathwaysfordegradationofpyrimidines
generallyleadtoNH4productionandthustourea
synthesis.
Thymine,forexample,isdegradedto
methylmalonylsemialdehyde(Fig.2246),an
intermediateofvalinecatabolism.Itisfurther
degradedthroughpropionylCoAand
methylmalonylCoAtosuccinylCoA(seeFig.18
27).

FIGURE2246Catabolismofapyrimidine.
Shownhereisthepathwayforthymine.The
methylmalonylsemialdehydeisfurtherdegradedto
succinylCoA.