Department of Pharmacology

ANTITROMBOSIT
M. Yulis Hamidy, dr., M.Kes., M.Pd.Ked

Faculty of Medicine University of Riau

Department of Pharmacology

ASPIRIN
Menghambat sintesis tromboksan A2
dalam trombosit dan prostasiklin
(PGI2) di pembuluh darah melalui
penghambatan siklooksigenase
Indikasi: IMA, TIA
ES: gangguan GIT

Faculty of Medicine University of Riau

Department of Pharmacology

DIPIRIDAMOL
Menghambat ambilan dan metabolisme adenosin
sehingga kadarnya meningkat
Menghambat fungsi trombosit dengan merangsang
adenilat siklase (suatu vasodilator)
Memperbesar efek antiagregasi prostasiklin
Indikasi: IMA, TIA
ES: sakit kepala, pusing, sinkop, gangguan GIT
90% terikat protein
Mengalami sirkulasi enterohepatik
T 1-12 jam
Dosis 400 mg/hari
Faculty of Medicine University of Riau

Department of Pharmacology

SULFINPIRAZON
Menghambat sistesis prostaglandin
ES: gangguan GIT, ruam kulit, diskrasia
darah, nefritis interstisialis akut, GGA
Dosis 800 mg/hari

Faculty of Medicine University of Riau

Department of Pharmacology

DEKSTRAN
Menghambat perlengketan trombosit
Mencegah bendungan pembuluh darah
dengan mempengaruhi aliran darah

Faculty of Medicine University of Riau

Department of Pharmacology

NATRIUM EPOPROSTENOL
(PROSTASIKLIN)
Menghambat agregasi trombosit
Melebarkan pembuluh darah
ES: flushing, sefalgia, mual, muntah,
gelisah, hipotensi

Faculty of Medicine University of Riau

Department of Pharmacology

TIKLOPIDIN HCl
Mempengaruhi membran trombosit
Mengurangi kekambuhan pada IMA
ES: gangguan GIT, perdarahan,
urtikaria, ruam kulit, gangguan fungsi
hati, gangguan darah, ikterus kolestatik

Faculty of Medicine University of Riau

Department of Pharmacology

Faculty of Medicine University of Riau