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    Abdul Kodir
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    This document discusses fungal meningitis, including Cryptococcus neoformans, Candida species, and Aspergillus species. It covers signs and symptoms, diagnostic tests, and treatment approaches. Cryptococcus neoformans is a leading cause of death in sub-Saharan Africa and has the highest incidence in immunocompromised AIDS patients. Candida albicans is the most common Candida species and more often affects babies than adults. Treatment is influenced by the host, pathogen, drug susceptibility, and drug delivery across the blood brain barrier, and may involve antifungal drugs like fluconazole, amphotericin B, and flucytosine alone or in combination depending on the infecting fungus

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    This document discusses fungal meningitis, including Cryptococcus neoformans, Candida species, and Aspergillus species. It covers signs and symptoms, diagnostic tests, and treatment approaches. Cryptococcus neoformans is a leading cause of death in sub-Saharan Africa and has the highest incidence in immunocompromised AIDS patients. Candida albicans is the most common Candida species and more often affects babies than adults. Treatment is influenced by the host, pathogen, drug susceptibility, and drug delivery across the blood brain barrier, and may involve antifungal drugs like fluconazole, amphotericin B, and flucytosine alone or in combination depending on the infecting fungus

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    13 views9 pages

    Fungal Infection (Autosaved)

    Uploaded by

    Abdul Kodir
    This document discusses fungal meningitis, including Cryptococcus neoformans, Candida species, and Aspergillus species. It covers signs and symptoms, diagnostic tests, and treatment approaches. Cryptococcus neoformans is a leading cause of death in sub-Saharan Africa and has the highest incidence in immunocompromised AIDS patients. Candida albicans is the most common Candida species and more often affects babies than adults. Treatment is influenced by the host, pathogen, drug susceptibility, and drug delivery across the blood brain barrier, and may involve antifungal drugs like fluconazole, amphotericin B, and flucytosine alone or in combination depending on the infecting fungus

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    © All Rights Reserved
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    of 9

    FUNGAL

    MENINGITIS
    By Hafizah, dr

    PENDAHULUAN
    Cryptococcus Neoformans

    Central
    Nervous
    System
    Infection

    Fungal
    Meningitis

    Candida Spesies

    Aspergilus Spesies

    Cryptococcus Neoformans
    C. Neoformans

    Causes of death in sub-Saharan Africa, excluding


    HIV/AIDS

    Insidensi tertinggi
    pada pasien
    Imunokompromis
    e pada AIDS
    Sign and Symptoms
    Headache
    Fever
    Neck Pain
    Nausea and vomiting
    Sensitivity to light
    Confusion or changes in
    behavior

    Adapted from BJ Park et al., AIDS 2009;23:525-530

    Candida Spesies

    Penyebab
    terbanyak dari
    spesies candida
    adalah Candida
    Albicans

    Lebih sering
    terjadi pada bayi
    dibandingkan
    pada orang
    dewasa

    Symptoms
    Fever
    Chills

    Aspergilus Spesies

    Diagnostics Tests
    Clinical
    Manifestation

    Neuroimaging
    (CT Scan atau
    MRI)

    CSF
    Cytochemical
    Characteristic
    s

    Fungal Test

    Treatment
    Transplantasi organ

    Insidensi
    mortalitas
    dan
    morbiditas

    Kemoterapi
    Perawatan ICU
    Pasien Imunokompromise
    Keganasan hematologi

    The
    treatment
    of fungal
    CNS
    infection is
    influenced
    by

    Host
    Pathogen
    Drug Susceptibility
    Drug Delivery across the blood brain
    barrier
    Drug activity in the CNS

    TREATMENT
    Combination
    Fluconazole
    Amphotericin B Candida
    Cryptococcus
    and/or
    flucytosine
    Candida
    C. Neoformans

    Itraconazole
    Aspergilus

    TERIMA KASIH

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