Linezolid Resistance

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Introduction
Introduction

Mechanism of Linezolid Resistance

Target Modifications
Modifications in
23S rRNA

Linezolid
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Introduction
Introduction

Linezolid Resistance is Mediated By Gene: cfr

Cfr: encodes an rRNA

methyltransferase

add a methyl group at the C-

8 position of 23S rRNA
nucleotide A2503

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Introduction
Introduction

Mutations in the domain V region of 23S rRNA genes

The nucleotides that form the

linezolid binding pocket:

Nucleotide positions where

mutations confer linezolid resistance:

Secondary structure of the

peptidyl transferase loop of
domain V of 23S rRNA
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