Testosterone in Fetal Life

Chorionic gonadotropin stimulates

production of testosterone
7th week production of testosterone
SRY gene testis determining factor
Descent of Testes last 2-3 months
of gestation
 BASIC INTRACELLULAR MECHANISM
OF ACTION OF TESTOSTERONE
1. Testosterone enters prostastic cells
2. Testosterone is converted to
dihydrotestosterone by 5 alpha-reductase
3. Dihydrotestosterone binds to cytoplasmic
receptor protein
4. Dihydrotestosterone migrates to nucleus
5. Dihydrotestosterone binds with nuclear protein
to induce DNA-RNA transcription
6. RNA polymerase become activated (increased
conc of RNA
7. Increased number of RNA