SYSTEMIC PATHOLOGY OF

NEUROENDROCRINE
 Nral Structure dan Function
Endocrine vs Eocrine glands
Paracrine glands (diffuse endocrine)
Autocrine effects
Hormones
Secondar messenger molecules (e.g.
cAMP)
 Pituitary
- Essential control functions over
endocrine sstem
- Adenohypophysis (755)
- Neurohypophysis (255)
Adrenal medulla
- Chromaffin cells dan sympatheti
 Endocrine pathology
Major disorders include
1. Hyperfunction
2. Hypofuncton
3. Tumours a. Benign , b. Malignant

. Considerations
1. Interdependency of endocrine system
2. Multiple endocrine neoplasia (MEN) syndromes
3. A hormone my have diverse clincal effects
 Hypopituitarism
75% loss of parenchyma
 resClinical feat
Hypofunction of adrenal cort
 ogyMorpho
Biasanya harmorrage atau
 Diabetes insipidus
Etiology
1. head trauma
Neoplasma
Pit or hypo

Polyuria
Increased
 Syndrome Of Inappropriate ADH
Secretion
Clinical features
Excess water reabsorption

sensory neuropatic
Motoric neuropatic
Autonomy neuropatic