KELOMPOK 3

ANWAR SAM
A.MUH FEBRI R.
RANI KARTIKAWATI P
RIDHA AMALIA ALWI
JAHRIANTI NUR TAHIR
DHEANA WATI PUTRI

Thiazolidinedione
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Overview of Glucose Regulation

Glucose

Defective insulin
secretion

-cell insulin
secretionPersistent
Hepatic Glucose
Output
Thiazolidinediones
Thiazolidinediones

Resistance to
Insulin action insulin action
 THIAZOLIDINEDIONE

New class of oral antidiabetics

e.g.: Rosiglitazone
Pioglitazone

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- Increase target tissue sensitivity to insulin by:
reducing hepatic glucose output & increase
glucose uptake & oxidation in muscles & adipose
tissues.
- Enhancing peripheral insulin sensitivity,
especially at the muscle and adipose tissue, via
activation of PPAR

MECHANISM OF ACTION
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 THIAZOLIDINEDIONE
- 99% absorbed
- Metabolized by liver
- 99% of drug binds to plasma proteins
- Half-life 3 4 h
- Eliminated via the urine 64% and feces 23%

PHARMACOKINETICS
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THE DUAL ACTION OF THIAZOLIDINEDIONES
REDUCES HBA1C

Insulin -cell
resistance IR
+ function

HbA1c

Lebovitz HE, et al. J Clin Endocrinol Metab 2001; 86:280288.

 THIAZOLIDINEDIONE
- Mild to moderate edema
- Wt gain
- Headache
- Myalgia
- Hepatotoxicity ?

ADVERSE EFFECTS
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 THIAZOLIDINEDIONE

Type 11 diabetes alone or in combination with

metformin or sulfonylurea or insulin in patients

resistant to insulin treatment.

INDICATIONS
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