Both significant factors have a positive effect on the dependent
variable. The faster the filling velocity, the higher the mean net weight of cans. The best operating condition for filling velocity to achieve the specified net weight is at 5 gallons per minute (gpm). Recommended process temperature of 75C which inhibits the oxidation of the tomato paste. A multiple regression analysis was performed using the experimental design data. Through this analysis, a mathematical model was developed, which explains 92.36% of the tomato filling process variability. The mathematical model for this study is: Y = 2882.35 3.1X1 + 2.76889X2 + 1.41556X3 + 0.033703X4 Where, Y = Net weight. The mathematical optimization of the tomato paste filling process is the selection of the best operating conditions to meet the specified target value (3.000 g). According to the mathematical model, if filling process is operated under optimum conditions suggested in this study, the mean net weight of tomato paste cans should be 2991.7 g. The results imply that the filling of tomato paste was moved left, so it could meet the specifications of the company.