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1 - Intro and Histo Grays
1 - Intro and Histo Grays
Human Anatomy
BIOL 1010
Liston Campus
What is Anatomy?
Anatomy (= morphology): study of body’s structure
Physiology: study of body’s function
Structure reflects Function!!!
Branches of Anatomy
Gross: Large structures
Surface: Landmarks
Histology: Cells and Tissues
Developmental: Structures change through life
Embryology: Structures form and develop before birth
Hierarchy of Structural
Organization
Each of these build upon one another
to make up the next level:
Chemical level
Cellular
Tissue
Organ
Organ system
Organism
Hierarchy of Structural
Organization
Chemical level
Atoms combine to make molecules
4 macromolecules in the body
Carbohydrates
Lipids
Proteins
Nucleic acids
Hierarchy of Structural
Organization
Cellular
Made up of cells and cellular organelles
(molecules)
Cells can be eukaryotic or prokaryotic
Organelles are structures within cells that
perform dedicated functions (“small organs”)
http://cmweb.pvschools.net/~bbecke/newell/Cells.html
Hierarchy of Structural
Organization
Tissue
Collection of cells that work together to
perform a specialized function
4 basic types of tissue in the human body:
Epithelium
Connective tissue
Muscle tissue
Nervous tissue
www.emc.maricopa.edu
Hierarchy of Structural
Organization
Organ
Made up of tissue
Heart
Brain
Liver
Pancreas, etc……
Pg 181
Hierarchy of Structural
Organization
Organ system (11)
Made up of a group of related organs that
work together
Integumentary
Skeletal
Muscular
Nervous
Endocrine
Cardiovascular Circulatory
Lymphatic
Respiratory
Digestive
Urinary
Reproductive
1)Epithelium
2)Connective
3)Muscle
4)Nervous
Tissues: groups of cells closely associated that
have a similar structure and perform a related function
Absorption
Ion Transport
Characteristics of Epithelium
Cellularity
Composed of cells
Specialized contacts
Joined by cell junctions
Polarity
Apical vs. Basal surfaces differ
Supported by connective tissue
Avascular
Innervated
Highly regenerative
Classification of Epithelium-based
on number of layers and cell shape
Layers
Simple
Stratified
Stratified layers characterized by shape of apical layer
Psuedostratified
Shapes
Squamous
Cuboidal
Columnar
Transitional
Types of Epithelium
Simple squamous (1 layer)
Lungs, blood vessels, ventral body cavity
Simple cuboidal
Kidney tubules, glands
Simple columnar
Stomach, intestines
Pseudostratified columnar
Respiratory passages (ciliated version)
Stratified squamous (>1 layer)
Epidermis, mouth, esophagus, vagina
Named so according to apical cell shape
Regenerate from below
Deep layers cuboidal and columnar
Mesothelium
Simple squamous epithelium that forms the lining
of body cavities
e.g. pleura, pericardium, peritoneum
Features of Apical Surface of
Epithelium
Microvilli: (ex) in small intestine
Finger-like extensions of the plasma membrane
of apical epithelial cell
Increase surface area for absorption
Cilia: (ex) respiratory tubes
Tight Junctions
Plasma membrane of adjacent cells fuse, nothing passes
Gap junction
Proteins allow small molecules to pass through
Features of the Basal Surface
of Epithelium
Basement membrane
Sheet between the epithelial and connective tissue
layers
Attaches epithelium to connective tissue below
Made up of:
Basal lamina: thin, non-cellular, supportive sheet made of
proteins
Superficial layer
Acts as a selective filter
Assists epithelial cell regeneration by moving new cells
Reticular fiber layer
Deeper layer
Support
Glands
Epithelial cells that make and secrete a
product
Products are water-based and usually contain
proteins
Classified as:
Unicellular vs. multicellular
Exocrine vs. Endocrine
Page 138
Glands: epithelial cells that make and
secrete a water-based substance w/proteins
Exocrine Glands
Secrete substance onto body surface or into
body cavity
Activity is local
Have ducts
Unicellular or Multicellular
(ex) goblet cells, salivary, mammary,
pancreas, liver
Glands: epithelial cells that make and
secrete a water-based substance w/proteins
Endocrine Glands
Secrete product into blood stream
Either stored in secretory cells or in follicle
surrounded by secretory cells
Hormones travel to target organ to increase
response (excitatory)
No ducts
(ex) pancreas, adrenal, pituitary, thyroid
4 Types of Tissue
1)Epithelium
2)Connective
3)Muscle
4)Nervous
4 Types of Connective Tissue
Areolar CT
All types of fibers present
All typical cell types present
Surrounds blood vessels and nerves
Specialized Loose CT Proper
Adipose tissue
Loaded with adipocytes, highly vascularized, high
metabolic activity
Insulates, produces energy, supports
Found in hypodermis under skin
Reticular CT
Contains only reticular fibers
Forms caverns to hold free cells, forms internal
“skeleton” of some organs
Found in bone marrow, holds blood cells, lymph
nodes, spleen
Dense/Fibrous Connective Tissue
Contains more collagen
Can resist extremely strong pulling forces
Regular vs. Irregular
Regular-fibers run same direction, parallel to pull
(eg) fascia, tendons, ligaments
Irregular-fibers thicker, run in different directions
(eg) dermis, fibrous capsules at ends of bones
Cells Matrix
Well-vascularized
Function:
support (eg) pelvic bowl, legs
protect (eg) skull, vertebrae
mineral storage (eg) calcium, phosphate
(inorganic component)
movement (eg) walk, grasp objects
blood-cell formation (eg) red bone marrow
Bone Tissue
Osteoblasts
Secrete organic part of bone matrix
Osteocytes
Mature bone cells
Sit in lacunae
Maintain bone matrix
Osteoclasts
Degrade and reabsorb bone
Periosteum
External layer of CT that surrounds bone
Outer: Dense irregular CT
Inner: Osteoblasts, osteoclasts
Endosteum
Internal layer of CT that lines cavities and covers trabeculae
Contains osteoblasts and osteoclasts
academic.kellogg.cc.mi.us/.../skeletal.htm
Compact Bone
External layer
Osteon (Haversian system)
Parallel to the long axis of the bone
Groups of concentric tubules (lamella)
Lamella = layer of bone matrix where all fibers run in the same
direction
Adjacent lamella fibers run in opposite directions
Haversian Canal runs through center of osteon
Contains blood vessels and nerves
Connected to each other by perforating (Volkman) canals
Interstitial lamellae fills spaces and forms periphery
www.mc.vanderbilt.edu/.../CartilageandBone03.htm
Bone Anatomy: Spongy bone
Diaphysis
Medullary Cavity
Nutrient Artery & Vein
2 Epiphyses
Epiphyseal Plates
Epiphyseal Artery & Vein
Periosteum
Does not cover epiphyses
Endosteum
Covers trabeculae of spongy bone
Lines medullary cavity of long bones
training.seer.cancer.gov/.../illu_long_bone.jpg
2 Types of Bone Formation
Intramembranous Ossification
Membrane bones: most skull bones and clavicle
Osteoblasts in membrane secrete osteoid that mineralizes
Endochondral Ossification: All other bones
Begins with a cartilaginous model
Cartilage calcifies
Medullary cavity is formed by action of osteoclasts
Epiphyses grow and eventually calcify
Epiphyseal plates remain cartilage for up to 20 years
Bone Growth & Remodeling
GROWTH
Appositional Growth = widening of bone
Bone tissue added on surface by osteoblasts of periosteum
Medullary cavity maintained by osteoclasts
Lengthening of Bone
Epiphyseal plates enlarge by chondroblasts
Matrix calcifies (chondrocytes die and disintegrate)
Bone tissue replaces cartilage on diaphysis side
REMODELING
Due to mechanical stresses on bones, their tissue needs
to be replaced
Osteoclasts-take up bone ( = breakdown) release Ca2++ , PO4 to
body fluids from bone
Osteoblasts-form new bone by secreting osteoid
Ideally osteoclasts & osteoblasts work at the same rate!
Components of Bone Tissue Summarized
Cells Matrix
Osteocytes
Osteoclasts
4) Blood: Atypical Connective Tissue
Function:
Transports waste, gases, nutrients,
hormones through cardiovascular system
Helps regulate body temperature
Protects body by fighting infection
Derived from mesenchyme
Hematopoiesis: production of blood cells
Occurs in red bone marrow
In adults, axial skeleton, girdles, proximal
epiphyses of humerus and femur
Blood Cells
Erythrocytes: (RBC) small, oxygen-transporting
most abundant in blood
no organelles, filled w/hemoglobin
pick up O2 at lungs, transport to rest of body
*Platelets = Thrombocytes:
fragments of cytoplasm
plug small tears in vessel walls, initiates clotting
Components of Blood Summarized
Cells Matrix
Erythrocytes Plasma
(red blood cells) (liquid matrix)
Leukocytes NO fibers
(white blood cells)
*Platelets
(cell fragments)
4 Types of Tissue
1)Epithelium
2)Connective
3)Muscle
4)Nervous
Muscle Tissue
Muscle cells/fibers
Elongated
Contain many myofilaments: Actin & Myosin
FUNCTION
Movement
Maintenance of posture
Joint Stabilization
Heat Generation
Three types: Skeletal, Cardiac, Smooth
Skeletal Muscle Tissue
(each skeletal muscle is an organ)
Cells
Long and cylindrical, in bundles
Multinucleate
Obvious Striations
Skeletal Muscles-Voluntary
Connective Tissue Components:
Endomysium-surrounds fibers
Perimysium-surrounds bundles
Epimysium-surrounds the muscle
Attached to bones, fascia, skin
Origin & Insertion
academic.kellogg.cc.mi.us/.../muscular.htm
Cardiac Muscle
Cells
Branching, chains of cells
Single or Binucleated
Striations
Connected by Intercalated discs
Cardiac Muscle-Involuntary
Myocardium-heart muscle
Pumps blood through vessels
Connective Tissue Component
Endomysium: surrounding cells www.answers.com
Smooth Muscle Tissue
Cells
Single cells, uninucleate
No striations
Smooth Muscle-Involuntary
2 layers-opposite orientation (peristalsis)
Found in hollow organs, blood vessels
Connective Tissue Component
Endomysium: surrounds cells
4 Types of Tissue
1)Epithelium
2)Connective
3)Muscle
4)Nervous
Nervous Tissue
www.morphonix.com
Nervous Tissue: control
Functions
Protection
Mechanical, thermal, chemical, UV
Cushions & insulates deeper organs
Prevention of water loss
Thermoregulation
Excretion
Salts, urea, water
Sensory reception
Microanatomy - Layers of the
Skin
Epidermis
Epithelium
Dermis
Connective tissue
Hypodermis / subcutis
Loose connective tissue
Anchors skin to bone or muscle
Skin Appendages = outgrowths of epidermis
Hair follicles
Sweat and Sebaceous glands
Nails
www.uptodate.com/.../Melanoma_anatomy.jpg
Cell Layers of the Epidermis
Stratum corneum
Dead keratinocytes
Stratum lucidum
Only in “thick” skin
Dead keratinocytes
Stratum granulosum
Water proofing
Stratum spinosum
Resists tears and tension
Stratum basale
Sensory receptors
Melanocytes
Keratinocytes (in all layers) 15minbeauty.blogspot.com
Layers of the Dermis
Highly innervated
Highly vascularized
Collagen & Elastic fibers
2 layers:
Papillary layer (20%)
Areolar CT
Collagen & Elastic fibers
Innervation
Hair follicles
Reticular layer (80%)
Dense irregular CT
Glands
sebum
2.5 million sweat glands!!
www.uptodate.com/.../Melanoma_anatomy.jpg
Smooth muscle fibers
Innervation
Hypodermis
Also called superficial fascia
Areolar & Adipose Connective Tissue
Functions
Store fat
Anchor skin to muscle, etc.
Insulation
Structure of Tubular Organs
LUMEN
Tunica Mucosa
Lamina epithelialis
Lamina propria
Lamina muscularis mucosa
Tunica Submucosa
Tunica Muscularis
Inner circular
Outer longitudinal
Tunica Adventitia / Serosa
Adventitia – covers organ directly
Serosa – suspends organ in the peritoneal cavity