Fungal infection

erly

Focus point:
Describe some of the virulence
determinants of fungi
• Pathogenesis of fungi involve :
- colonization
- evasion of host defenses,and damage to the
host
- The mechanisms,however,are generally not
well understood.
 Eukaryotic Parasites

• Attach to host cells via spesific receptors

• Use a variety mechanisms to avoid antibodies
• Some can produce enzymes that digest host
tissue,causing direct damage
• Damage is due to the immune response
 Classification Fungal Infection

1. Superficial fungal infection

2. Cutaneus fungal infection
3. Deep/systemic fungal infection
• In general ,intact skin and mucosal surface 
barrier to infection
- Fatty acid
- pH
-Turn over of the skin
- Normal bacterial flora
 Pityriasis versicolor
• = Tinea versicolor
• Causal: Malassezia furfur ,yeast like
• Lipophilic
• Generally harmless
• In some people,cause scally face rash,dandruff
• Common skin disease patchy scallines and
increased or decrease in pigment in skin
people.
• Skin scrapping: yeast form and short filaments
“mi bakso”
• Unknown factors,probably relating to the host
• Tinea nigra
• Piedra

The infections “cosmetic problems”

Easily diagnosed and treated
Infections of the skin  are limited to the outer
most layers of str. Corneum
Do not elicit a cellular response
• Medical microbiology
• Medical microbiology and immunology
 Cutaneus mycoses

• Disease of the skin,hair and nail keratinized

layers
• Cellular immune response may be evoke in
cutaneous infections pathological changes
•  expressed in the deeper tissues of the skin
• Disease: Dermatophytoses
• Clinical manifestation ring worm or tinea
• Tinea capitis,corporis,cruris,manus,pedis and
unguium
• Favus
• Tokelausuku Dayak-Kalimantan
• Tinea  snake like and annularlesions
 Dermatophytes
1. Microsporum
2. Trichophyton
3. Epidermophyton

• Geophilic (soil)
• Zoophilic( animal and birds)
• Anthropophilic(human)
• Anthropophilic chronic infectiondificult to
cure
• Geophilic and zoophilic respons well to
therapy and heal spontaneously
• Adelicate balance between host and fungi
• “keratophilic fungi”
• Keratinases have been isolated from some
of these fungi
• Unable to invade organs other than the
keratinazed layers of the skin,hair and nails
TERIMA KASIH