Ihsanil Husna

Defenition
 Peningkatan jumlah sel darah merah
 ( hemoglobin) dan nilai hemaqtokrit
 Bisa ok peningkatan jumlah sel darah merah atau
berkurangnya jumlah volume plasma darah
klasifikasi
 Primer; Penyakit myeloproliferatif dgn eritrosit
normal /berkurang
 Sekunder:
 Peningkatan kadar eritropoietin
 sebagai respons hipoksia
 PPOK, PJK kongenital (VSD),
 Smoker.TempatKetinggian

GGN produksi: kel ginjal, Ca, kosta, Hidronefrosis.

Tumorrenal,hepar,uteri,cerebral
 Clasification

 Primer
 Sekunder
 Relative
Clinical manifestation
• Primary and secondary
• Trombotic disease
• Headache and dizziness
• Lethargy and weakness
• Visual disturbance
• Sweating (berkeringat)
• Weight loss
• Plethoric appearance
• hypertension
Only primary polycitaemia
 Gout
 Peptic ulcer
 Bleeding ( spec GIT)
 Pruritus
 Splenomegaly
 hepatosplenomegaly
Laboratory findings
• Hb,PCT and RBC should be raised at least two
accasions before next investigation are endertaken
• WBC and Platelet count
• Uric acid
• Estimation of red cell mass and plasma volume
(essential investigation )
• Iron Total iron binding capacity
• B12 serum level
• BMP
• O2 saturation
• Urine microscopy
• LDH (yeloproliferatif diseases)
Secondary polycitaemia
• Treat any primery cause
• In pulmonary and cardiaovascular disease there I
a balance between benefficial effects of an
increased red blood cell increasing oxygen
delivery to the tissue to increased blood
viscosity,and judicious nenasection with careful
monitoring of clinical atate can helpful in seleced
patients in maintaining optimum level
Management
 Keep PCV < 45%
 Venasection
 Radioactive Phosporus (32P) can be repeated as
necessary
 Chemotherapy: Alkylating agent ex; busulphan 2-6
mg/po/d
 Appoximately 10% trnasform to Acute myeloid
leukemia