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Mechanism of Bacterial Pathogenesis
Mechanism of Bacterial Pathogenesis
Infection
pathogenesis
Pathogen
microbials
HOST
INFECTIOUS PROCESS
1. CONTAMINATION
2. INTERACTION
3. COLONIZATION
4. INVATION
5. INFECTION
6. TRANSMISSION
7. CARRIER
1. CONTAMINATION
Transient flora
Microorganisms that are present at area of the
host body for temporarily
True Pathogen
• An organism that can cause infection in
individuals with normal host defences (healthy
immune-competent)
• Ex : Microbacterium tuberculosa
2. INTERACTION
– most microbes that enter the G.I. Tract are destroyed by HCL
& enzymes of stomach or bile & enzymes of small intestine
Skin
Unbroken skin is impenetrable by most microbes.
Tissue-Degrading Enzymes
Many bacteria produce substances that are cytolysins—ie, they dissolve red
blood cells (hemolysins) or kill tissue cells or leukocytes (leukocidins).
6. TRANSMISSION
Transmit → Transmission :
a passage or transfer ( as of a disease) from
one individual to another
Airborne transmission
Human to human, No Direct Contact
Airborne Diseases :
Tuberculosis, Influenza, swine flu
Food and water transmission
Human to human, No Direct Contact
RABIES
Animal Vector
• Non human to human, Insects, Arthropods
AVIAN FLU
Soil Source
Non Human to human
Tetanus
Water source
• Non human to human
Leptospirosis
On an object/surface
Non human to human