Professional Documents
Culture Documents
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Conflicts of interest
• None to declare
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Combining exercise and diet interventions
in OBESE asthma patients
• Scot HA et al (2013)
• Freitas P et al (2016)
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Effects of exercise and diet interventions in (non-obese)
asthma patients
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Aim
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EFFORT ASTHMA
8- week intervention
4 groups
• Exercise
• Diet
• Exercise+diet
• Control group
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Outcomes and assessment
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The exercise intervention
week
10 min warm-up
50
• 10 min warm-up
followed by 12-30
min. high-intensity 25
interval training
0
5 10 15 20 25 30
time /min.
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The diet intervention
• Ad-libitum
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Inclusion criteria
• 18-65 years
• BMI <30
• ACQ >/= 1
• On a stable treatment regime
• A positive test suggesting asthma*
Exclusion criteria
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Screened for eligibility
(n=312)
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Baseline measurements
N (completed study) 29 33 29 34
Age (years) 39.4 (12.5) 40.7 (14.7) 43.7 (13.9) 38.2 (12.7) 0.8
BMI (kg/m2) 24.9 (2.5) 25.0 (2.8) 26.1 (2.5) 25.5 (2.4) 0.8
ACQ 1.7 (0.6) 2.0 (0.6) 1.9 (0.7) 1.8 (0.7) 0.7
FEV1 %pred. 84.9 (12.6) 87.6 (14.5 82.6 (15.2) 81.9 (12.3) 0.6
Exercise
Exercise Diet Control p-value
+diet
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Results
Primary outcome: Asthma control questionnaire (ACQ)
P-
Pre Post Pre Post Pre Post Pre Post
value
Sputum
4.5 0.5 7.8 1.5
eosinophils 2.5 (13.5) 0.5 (2.5) 4.8 (13.1) 0.8 (5.2) 0.19
(15.1) (5.8) (14.9) (6.7)
(%) §, §§
Sputum 43.0
61.3 54.3 60.3
neutrophils 57.3 (18.1) 61.0 (45.5) 46.3 (33.6) 55.4 (33.5) 0.21
(12.0) (26.0) (52.4) (41.0)
(%) §, §§
Blood
0.19 0.16 0.21 0.18
eosinophils 0.19 (0.16) 0.13 (0.18) 0.21 (0.14) 0.18 (0.26) 0.06
(0.22) (0.23) (0.14) (0.19)
(x10-9/l) §
§: Median (IQR)
§§: No. of patients= 21, 25, 20 and 24 in the exercise-, diet-, exercise+diet- and control group, respectively
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Results: AHR (changes in doubling-dose)
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Conclusion
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University Hospital Bispebjerg, Dep. of Respiratory Medicine
Acknowledgements
Vibeke Backer
Celeste Porsbjerg
Morten Hostrup
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University Hospital Bispebjerg, Dep. of Respiratory Medicine
Thank you
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Regression coefficients (B) indicating the change in ACQ and AQLQ
in the three intervention groups when compared to the change in
the control group (reference group).
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Results (Paper II)
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Results (Paper II)
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