VITILIGO

Definition

It is an acquired, often
disfiguring, anomaly of the
skin manifested by
depigmented white patches
surrounded by anormal or a
hiperpigmented.
 Etiology

Complex :

 Genetic predisposition.

 Precipitating factors.
Clinical Manifestation
 Macula has a chalk or
milk-white color.
 Several variation :
• Trichrome vitiligo.
• Quadrichrome vitiligo.
• Pentachrome vitiligo.
• Inflammatory vitiligo.
 Types of Vitiligo

1. Focal vitiligo.

2. Segmental vitiligo

3. Generalized vitiligo.

4. Other cutaneus abnormalities.

 Incidence

1 - 2% of the population

(0.14 - 8.8%).
 Prevalence

 All races are affected.

 Sex : male = female.

 Developed at any age.

 Peak age of onset : 10 - 30

years.
 Histopathology

 Absence of dopa-positive

melanocytes.

 Langerhans cell no

increased.
 Pathogenesis

 Autoimmunity.

 Neurohumoral.

 Exogenous chemical exposures.

 Diagnosis

 Anamnesis.

 Clinical manifestation.

 Histopathology.
 Treatment

 Spontaneus repigmentation
(15 - 25%).
 Puva : repigmentation (50 -
70).
 Systemic steroid.
 Surgical therapy.
Vitiligo repigmentation
Universal vitiligo
Vitiligo perioral After treatment
After discontinuation of treatment