Creative Bioarray

The Complete Guide to Know

about Cell Therapy from The
Point of Standardization, Scale,
and Industrialization
What is cell therapy? The Defects of Cell Therapy

Difficulties in Cell Therapy Future development

 Creative Bioarray

PART ONE
What is cell therapy?
What is cell therapy?

Brief Introduction

Cell therapy refers to the transplantation or input of normal or bioengineered human cells into a
patient's body and newly-imported cells can replace damaged cells or involve a stronger
immune killing function, so as to achieve the purpose of treating diseases. Cell therapy has
shown higher application value in the treatment of cancer, hematological diseases,
cardiovascular diseases, diabetes, Alzheimer's disease etc. In general, cell therapy includes
tumor cell immunotherapy and stem cell therapy. There are two cell sources for cell therapy, one
from the patient itself and the other from the allogeneic tissue.
 Creative Bioarray

PART TWO
The Defects of Cell
Therapy
The Defects of Cell Therapy

The cell is the most basic unit that contributes to a living organism, however, it does not mean
that everyone shares the same cells. On the contrary, there is a huge difference in each
individual which can be compared to human-to-human differences, that is, two identical
people never exist. The huge difference between cells and cell preparations is the biggest
drawback of cell therapy. In this post, we will discuss several issues that need attention in the
current stage of cell therapy.
 Creative Bioarray

PART Three
Difficulties in Cell Therapy
 Difficulties in the Standardization
Taking stem cell therapy that using
umbilical cord mesenchymal stem
cells as an example, which raw
material is an umbilical cord, and
one umbilical cord-produced cell can
be utilized by many paitients. The
standardization path is more
advanced than the immunotherapy
Cancer cell immunotherapy cannot be of tumor cells, and the raw materials
standardized from the stage of raw can be standardized to some extent.
material acquisition. The cell treatment
materiasl for each paitient are their own
blood leukocytes. The condition and
physical condition of each patient are
different, and the collected white blood
cell growth quantity and kill activity are
not uniform and cannot be standardized.
 Difficulties in The Scale of Cell Therapy

At present, the production mode of the cell therapy

industry maily depends on technicians. In the 10,000-
Due to the small scale, the instruments used are
grade clean laboratory, the cells are operated in a
laboratory instruments and many of the reagents
class 100 clean bench, cultured in a carbon dioxide
used are scientific reagents, which will lead to the
incubator, centrifuged in a centrifuge, observed
issue of low efficiency but high cost.
through an inverted microscope, and the drug
reagents are stored in a medicine refrigerator.
Autologous or Allogeneic cells

For allogeneic cell therapy that using

allogeneic cells as raw materials, the
standardized properties of the scaled
There are two kinds of cell products can be realized if large-scale
sources for cell therapy, one cultures are prepared, then scale and
from the patients and the standardization can promote each
If the advanced technology cannot
other from the allogeneic other.
be mass-produced on a large scale,
tissue.
it can only stay in the laboratory and
become the object of research for
scientists, never have achance to
become a drug into the majority of
patients.
Natural cytokine supernatants with more standardized and
standardized properties

Brief Introduction on cytokine

Cytokines are a class of small molecule proteins with broad biological activity synthesized and secreted by
immune cells (such as monocytes, macrophages, T cells, B cells, NK cells, etc.) and certain non-immune
cells (endothelial cells, epidermal cells, fibroblasts, etc.) Immune responses are regulated by binding to the
respective receptors to regulate cell growth, differentiation and effects. Cytokines (CK) are low-molecular-
weight soluble proteins that are produced by various types of cells induced by immunogens, mitogens, or
other stimulants. They have the ability to regulate innate immunity [1] and adaptive immunity [2],
hematopoiesis, cell growth, and damage tissue repair and other functions.
Classification of Cytokines

. interleukins,

. interferons,

. tumor necrosis factor

superfamily,

. colony stimulating factors,

. chemokines,

. growth factors
 Creative Bioarray

PART Four
Future Development
Future Development

In recent years, recombinant

gene cytokines have made
remarkable achievements in
clinical applications as a novel
biological response modifier. A
large part of the effects of stem
cell therapy and immune cell
therapy arises from the action
of cytokines secreted in the
body.
 Future Development

The stem cells and immune cells in the body

are introduced back into the body to secrete
a variety of natural structural cytokines.
Although the amount of these cytokines is
relatively small, they are synergistic and act
directly on the cytokine network in the body
because of their high natural structure activity,
lack of antigenicity but diversity. Because of
the standardization, standardization,
industrialization, and scale of natural
compound cytokines, it is more cost-effective
than cell therapy, allowing more patients in
need to enjoy cell-like therapeutic effects.
 Creative Bioarray

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