Leptospirosis is a bacterial

disease related to genus

Leptospira which cause
septicemia, It is rare in cats
but more common in dogs,
cattle
Leptospirosis is a zoonotic
disease
NB: (human).
In man: it causes Weil’s disease
 Localized in

jaundice

Uterus in
pregnant animal

abortion
Septicemia
septicemia leads to petechial
hemorrhages and edema
on serous membranes (pleura )
may be seen in other organs as :
myocardium ,
adrenal glands,
pancreas,
gallbladder
and lung
Pulmonary hemorrhage
A-Canine Leptospirosis:
Pathognomonic Lesions:
Acute leptospirosis:
Liver:
Macroscopic Picture :
1-The liver is enlarged and yellow in
color.
2-Yellow m.m. due to icterus.
3-Peticheal hemorrhages on the pleura,
pericardium and peritoneum.
Icterus
 Microscopic Picture:
.
1- coagulative necrosis in hepatic cells.
2-Dissociation of the hepatic cells
(individualization).
3-hemolytic jaundice with dilation of the bile
canaliculi with yellow bile pigments.
4-Hemosiderosis are seen in the kupffer cells.
Organ : Liver.
Stain : H&E.
Micro : Dissociation and individualization hepatic
cells.
B- Bovine leptospirosis
Subacute and Chronic leptospirosis:
Macroscopic Picture:
1-The kidneys are enlarged & atrophied
(chronic).
2-Grayish-white spots throughout the
cortex (white spotted kidney) and
the capsule is not easily detached.
3-Smooth or pitted surface with
hemorrhage at the corticomedullary
junction.
.
Microscopic Picture:
1-Agggregations of lymphocytes
2-Extenssive coagulative necrosis.
3-Fibrosis and cystic dilation of some
renal tubules in chronic stage.
4-Cellular and hyaline casts