Appendicitis is the most common abdominal emergency and accounts for more than 40 000 hospital admissions in England every year. Appendicitis is most common between the ages of 10 and 20 years, but no age is exempt. A male preponderance exists, with a male to female ratio of 1.4:1; the overall lifetime risk is 8.6% for males and 6.7% for females in the United States. How do I diagnose it? Diagnosis of acute appendicitis relies on a thorough history and examination. What investigations might help? Differential diagnosis How do I treat it? Herbert Fitz was the first author to publish on the need for early diagnosis and surgery for acute appendicitis. No good evidence exists to support the notion that analgesia should be withheld on the grounds that it may cloud the clinical picture. All patients should receive broad spectrum perioperative antibiotics (one to three doses), as they have been shown to decrease the incidence of postoperative wound infection and intra- abdominal abscess formation. What are the complications? Despite this, complications can occur after removal of a normal appendix, and the surgical community continues to strive to reduce the numbers of negative procedures. According to a large historical cohort study, a perforated appendix during childhood does not seem to have a long term detrimental effect on subsequent female fertility